%A WANG Xiao-Li, CHANG Yong-Chao, LIU Gang %T Role and regulatory mechanism of microRNA449 in cancer %0 Journal Article %D 2016 %J Journal of International Oncology %R %P 110- %V 43 %N 2 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9885.shtml} %8 2016-02-08 %X More than 50% microRNAs (miRNAs) are located in tumorassociated genome of amplification region or fragile site, which may also act as oncogenes or tumor suppressor gene (TSG). Recently, researches show that the expression of miR449 is lower in human gastric, lung and ovarian cancer, and may act as TSG. The abnormal expression of miR449 plays a pivotal role in carcinogenesis and progression, and elucidating its function and regulatory mechanism can provide valuable diagnostic, prognostic biomarker for cancer management.