%A GAO Jun-Rong, ZHANG Ti, CAO Man-Qing, ZHANG Xue-Jun, ZHU Xiao-Lin %T Anticancer effect of metformin and regulation on HIF-1α %0 Journal Article %D 2016 %J Journal of International Oncology %R %P 113- %V 43 %N 2 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9886.shtml} %8 2016-02-08 %X Studies show that metformin inhibits the proliferation of several types of cancer cells. All evidences, therefore propose the antitumor effect of metformin. Metformin can repress the oxygen consumption of tumor cells, and suppress hypoxiainducible factor-1α (HIF-1α) accumulation through the translational and posttranslational mechanisms, and suppress the expression of HIF-1α by activating AMPactivated protein kinase (AMPK).