研究概述:通过运用光遗传、钙成像、电生理、行为学、病理模型等技术研究神经精神疾病如阿尔茨海默病、帕金森病、抑郁症等疾病的神经环路机制,以及运动、空间学习记忆的产生,情绪记忆的形成与存储等脑环路基础。
发表论文:
1.Wang, W.Q., Zhao, H.X., Shen, X.L., Zheng, L.Z.,Geng, H.Y.*(2024) Estrogen Receptor Alpha–Expressing Neurons in Bed Nucleus of the Stria Terminalis and Hypothalamus Encoding Aggression and Mating.eNeuro. 11,11.
2.Abdurahman, M., Xiao,Y.H., Zeng, L.Z., andGeng, H.Y.*(2024).Neurotensin modulates emotional valence assignment in basolateral amygdala through neuromodulator gain.Neurosci Bull.
3.Tan, P.Y., Shen X.-L., Zeng, L.Z., Weng, X.C., andGeng, H.Y.*(2024) Pharmacotherapy for the Core Symptoms of Autism Spectrum Disorders.J Zhejiang Univ-Sc B. 25(11):956-971.
4.Kou, Z.Q., Chen, C.Y., Abdurahman, M., Weng, X.C., Hu, C., andGeng, H.Y.*(2023). The Claustrum Controls Motor Activity Through Anterior Cingulate Cortex Input and Local Circuit Synchronization in a Preparatory Manner.Neurosci Bull39, 1591-1594.
5.Chen, C.Y., Yang, G.Y., Tu, H.X., Weng, X.C., Hu, C., andGeng, H.Y.*(2023). The cognitive dysfunction of claustrum on Alzheimer's disease: A mini-review.Front Aging Neurosci15, 1109256.
6.Yang, G.Y.#,Geng, H.Y.#, and Hu, C. (2022). Targeting 5-HT as a Potential Treatment for Social Deficits in Autism.Neurosci Bull38, 1263-1266.
7.Geng, H.Y., Arbuthnott, G., Yung, W.H., and Ke, Y. (2021). Long-Range Monosynaptic Inputs Targeting Apical and Basal Dendrites of Primary Motor Cortex Deep Output Neurons.Cereb Cortex. 10.1093/cercor/bhab460.
8.Mu, M.D.#,Geng, H.Y.#, Rong, K.L.#, Peng, R.C., Wang, S.T., Geng, L.T., Qian, Z.M., Yung, W.H., and Ke, Y. (2020). A limbic circuitry involved in emotional stress-induced grooming.Nat Commun11, 2261.
9.Cui, Q.#, Li, Q.#,Geng, H.Y.#, Chen, L., Ip, N.Y., Ke, Y., and Yung, W.H.(2018). Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex-nucleus accumbens pathway in mice.Proc Natl Acad SciU S A115, E4890-E4899.
10.Geng, H.Y.#, Zhang, J.#, Yang, J.M., Li, Y., Wang, N., Ye, M., Chen, X.J., Lian, H., and Li, X.M. (2017). Erbb4 Deletion from Medium Spiny Neurons of the Nucleus Accumbens Core Induces Schizophrenia-Like Behaviors via Elevated GABAA Receptor alpha1 SubunitExpression.J Neurosci37, 7450-7464.