姓名：刘婷婷
硕士生导师
职称：副教授
联系方式：liutingting@sdfmu.edu.cn; 15853121615@163.com
课题组主页：http://www.x-mol.com/groups/tina-liu
研究方向：
1.靶向肿瘤小分子荧光探针的设计、合成及评价研究
2.靶向肿瘤的小分子抑制剂的设计、合成及评价研究
主要学术任职：
1.山东生物医学工程学会医美药分子工程专业委员会，委员；
2. J. Med. Chem., Eur. J. Med. Chem.等期刊审稿人；
主要获奖情况（包括作为指导教师）：
1.“科巢杯”第九届山东省大学生医药生物技术技能大赛一等奖，山东省教育厅，2022；
2.第八届全国大学生基础医学创新实验设计大赛东部赛区优秀奖，高等学校国家级实验教学示范中心联席会，2022；
3.山东省微课比赛二等奖，山东省教育厅，2022；
4.山东省青年教学大赛优秀奖，山东省教育厅，2022；
5.全国第二届“智慧树杯”课程思政示范案例教学大赛一等奖，智慧树网，2022；
6.于金明科技创新奖，betway必威登陆网址 ，2021；
7.山东省课程思政示范案例三等奖，山东省高等医学教育研究中心，2021；
主持科研课题：
1.国家自然科学基金青年基金项目，8210131454，新型BRD4荧光探针的构建及其在乳腺癌成像分析中的应用研究，2022.01-2024.12，30万元，主持。
2.山东省自然科学基金青年项目，ZR2020QH344，新型环境敏感型Mcl-1荧光探针的设计、合成及成像应用研究，2021.01-2023.12，14万元，主持。
3.山东省医药卫生科技发展计划项目，2019WS393，新型环境敏感型Mcl-1荧光探针的设计、合成及生物成像应用研究，2020.06-2022.06，2万元，已结题。
近五年代表性论文（限第一作者和通讯作者）：
1.Yuqi Gao1, Jie Zhang1,JianJun Li, Shubin Song, Sitao Zhang, Qiao Liu, Xu Wang, Jinbo Zhao, Chengcai Xia, Yuliang Xiao**,Tingting Liu*.Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor,European Journal of Medicinal Chemistry, 2023,257,115478.
2.Yingfei Liu, Jianjun Li, Guanghui Zhou, Jiale Zhang, Yu Teng, Zhushuang Bai*,Tingting Liu*. Design, synthesis and anticancer activity studies of novel indole derivatives as Bcl-2/Mcl-1 dual inhibitors. Medicinal Chemistry Research, 2023, 32, 99-108.
3. Wenwen Cao, Yu Zhu, Fapu Wu, Yang Tian, Zhaoming Chen, Weijia Xu, Senyao Liu,Tingting Liu*, and Hu Xiong*. Three Birds with One Stone: Acceptor Engineering of Hemicyanine Dye with NIR-II Emission for Synergistic Photodynamic and Photothermal Anticancer Therapy. Small, 2022,18, 2204851.
4. Jie Zhang, Yuqi Gao, Zipeng Zhang, Jinbo Zhao, Wenshuang Jia, Chengcai Xia, Fugang Wang*,Tingting Liu*. Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment. Journal Medicinal Chemistry, 2022, 65, 16099−16127.
5.Tingting Liu*, Shubin Song, Xu Wang, Jifu Hao. Small-molecule inhibitors of breast cancer-related targets: Potential therapeutic agents for breast cancer. European Journal of Medicinal Chemistry, 2021, 210, 112954.
6. Zheng Zhang#, Xiaolan Xing#, Peng Guan, Shubin Song, Guirong You, Chengcai Xia,Tingting Liu*. Recent progress in agents targeting polo-like kinases: Promising therapeutic strategies. European Journal of Medicinal Chemistry, 2021, 217, 113314.
7. Sitao Zhang, Yanzhao Chen, Chengsen Tian, Yujing He, Zeru Tian, Yichao Wan andTingting Liu*. Dual-target inhibitors based on BRD4: Novel therapeutic approaches for cancer. Current Medicinal Chemistry, 2021, 28, 1775-1795
8.Tingting Liu*, Yichao Wan, Yuliang Xiao, Chengcai Xia, Guiyun Duan. Dual-target inhibitors based on HDACs: Novel antitumor agents for cancer therapy. Journal of Medicinal Chemistry, 2020, 63, 8977-9002.
9.Tingting Liu*, Zhongyu Wu, Yujing He, Yuliang Xiao, Chengcai Xia. Single and dual target inhibitors based on Bcl-2: Promising anti-tumor agents for cancer therapy. European Journal of Medicinal Chemistry, 2020, 201, 112446-112458.
10. Yichao Wan*, Chunxing Yan, Han Gao,Tingting Liu*. Small-molecule PROTACs: Novel agents for cancer therapy. Future Medicinal Chemistry, 2020, 12, 1756-8919.
11.Tingting Liu, Gaopan Dong, Feng Xu, Bowen Han, Hao Fang, YunHuang, Yubin Zhou, Lupei Du, Minyong Li*. Discovery of turn-On fluorescent probes for detecting Bcl-2 Protein. Analytical Chemistry, 2019, 91, 5722-5728.
12.Tingting Liu, Yuqi Gao, Xiaomeng Zhang, Yichao Wan, Lupei Du, Hao Fang, Minyong Li*. Discovery of a turn-On fluorescent probe for myeloid cell leukemia‑1 protein. Analytical Chemistry, 2017, 89, 11173-11177.
13.Tingting Liu, Yichao Wan, Renshuai Liu, Lin Ma, Minyong Li, Hao Fang*. Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25, 1939-1948.
14.Tingting Liu#, Yan Jiang#, Zhenzhen Liu, Jin Li, Kun Fang, Chunlin Zhuang, Lupei Du, Hao Fang, Chunquan Sheng* and Minyong Li*. Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction. MedChemComm, 2017, 8, 1727-1732.
