
姓名:卢志远
硕士生导师
职称:副教授
联系方式:luzhiyuan@sdfmu.edu.cn
研究方向:
1.基于新颖靶标的天然药物分子发现
2.抗炎类、抗菌类以及活血类中药活性成分发现和靶点蛋白生物学功能研究
主要学术任职:
1.《Traditional Medicine Research》客座编辑
2.《TMR Pharmacology Research》编委
3.中国药理学会生化与分子药理学专业委员会青年委员
主要获奖情况(包括作为指导教师):
主持科研课题:
1.国家自然科学基金青年项目,32300957,磷酸酶PPM1B调控巨噬细胞M1型极化介导溃疡性结肠炎发展的分子机制研究,30万,2024.01-2026.12,在研。
2.山东省自然科学基金青年项目,ZR2023QH427,基于蛋白磷酸酶PPM1B的急性B淋巴细胞白血病治疗新靶标的发现,2024.01-2026.12,15万,在研。
3.山东省高等学校“青创团队计划”,2022KJ197,参麦注射液抗新冠肺炎危重症感染的活性成分及分子机制研究,2023.01-2025.12,30万,在研。
4.山东省医药卫生科技发展计划项目-青年项目,Q-2023107,党参碳量子点的制备、表征及在贫血治疗中的应用,2023.08-2025.07,2万,在研。
5.betway必威登陆网址 高层次人才引进经费资助项目,2022.07-2027.06,200万,在研。
近五年代表性论文(限第一作者和通讯作者):
1.Zhiyuan Lu#, Lixia Huang#, Yanxia Li, Yan Xu, Ruihao Zhang, Qian Zhou, Qi Sun, Yi Lu, Junjie Chen, Yuemao Shen*, Jian Li*, Baobing Zhao*. Fine-tuning of cholesterol homeostasis controls erythroid differentiation. Advanced Science. 2021,2102669:1-17.
2.Zhiyuan Lu#, Hanzhi Yu#, Yanxia Li, et al. Phosphatase, Mg2+/Mn2+ Dependent 1B regulates the hematopoietic stem cells homeostasis via the Wnt/-catenin signaling. Haematologica.2023, 284305.
3.Zhiyuan Lu#, Guangsen Xu#, Yanxia Li#, Chunhua Lu, Yuemao Shen, Baobing Zhao. Discovery of N-arylcinnamamides as Novel Erythroblast Enucleation Inducers. Bioorganic Chemistry. 2022, 128:106105.
4.Zhongyao Li#, Ruoyu Chen#, Yanxia Li#, Qian Zhou, Huanxin Zhao, Kewu Zeng*, Baobing Zhao*,Zhiyuan Lu*. A comprehensive overview of PPM1B: From biological functions to diseases.European Journal of Pharmacology. 2023, 947: 175633.
5.Zhiyuan Lu#, Peng Xiao#, Yuan Zhou, Zhenyu Li, Xiao Yu, Jinpeng Sun, Yuemao Shen, Baobing Zhao*. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. Journal of Cellular and Molecular Medicine. 2020, 00: 1-9.
6.Shuai Wang#,Zhiyuan Lu#, Yuxin Wang, Tianran Zhang, Xiaodong He*.Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats. Nutrition & Metabolism. 2020, 17: 66.
7.Ming-Jie Liu#, Zhi-Fang Liu#, Huanxin Zhao#, Qi Wang, Zhong-Yao Li, Ming-Wei Sun, Mi Xiao, Qian Zhou,Yuan Li, Tao Shen, Bao-Bing Zhao, Ke-Wu Zeng*,Zhi-Yuan Lu*.TMR Pharmacol Res. 2023;3(1):4.