
柳珊珊,女,1992年4月生,副教授,口腔医学博士,硕士生导师,住院医师。ORCID:0000-0002-0104-8802。电子邮箱:liushanshan@sdfmu.edu.cn。
2022.09-至今 口腔正畸教研室 betway必威登陆网址 ;
2017.09-2022.06硕博连读 山东大学;
2011.09-2016.06本科 betway必威登陆网址 。
科研方面:从事骨代谢学、骨免疫等方面的基础研究工作7年,主要研究方向是(1)氧化应激诱导细胞焦亡导致成骨功能障碍的发病机制;(2)牙周炎背景下调节性T细胞TH17-Treg偏移的调控机制;(3)抑癌因子影响口腔鳞状细胞癌生物学行为的机制;(4)正畸牙齿移动过程中骨改建的相关机制。目前已发表相关学术论文16篇,其中SCI收录论文16篇,累计影响因子达80.314分;单篇最高影响因子10.75分。指导大学生发表SCI论文2篇。主持山东省自然科学基金青年项目1项,参与国家自然科学基金面上项目2项、国家自然科学基金青年项目1项。
临床方面:从事正畸临床工作5年,熟练掌握儿童和成人牙颌畸形常见病和多发病的诊断和治疗,特别是在成年人上颌骨宽度发育不足的骨性扩弓治疗以及严重骨骼畸形的正畸-正颌联合治疗方面积累了一定经验。
近5年代表性学术成果:
1.Liu S, Gao W, Lu Y, Zhou Q, Su R, Hasegawa T, Du J, Li M. As a Novel Tumor Suppressor, LHPP
Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma. Int J Biol Sci. 2022; 18(2):491-506.IF=10.75
2.Du J, Zhou W, Sun Z, Zhang W, Luo W,Liu S. Peroxiredoxin 1 promotes proliferation and inhibits differentiation of MC3T3-E1 cells via AKT1 / NF-κB signaling pathway. J Oral Biosci. 2024 Jun;66(2):403-411. doi: 10.1016/j.job.2024.04.007.IF=2.6
3.Liu S, Du J, Li D, Yang P, Kou Y, Li C, Zhou Q, Lu Y, Hasegawa T, Li M: Oxidative stress induced
pyroptosis leads to osteogenic dysfunction of MG63 cells. J Mol Histol. 51(3): 221-232, 2020.IF=2.9
4.Lu Y,Liu S, Yang P, Li M. Exendin-4 and Eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K/AKT pathway. Stem Cell Res Ther. 2022 Mar 21;13(1):113.IF=7.1
5.Ye M, Liu T,Liu S, Tang R, Liu H, Zhang F, Luo S, Li M. Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival. Cell Death Discov. 2023 Nov 25;9(1):425.IF=6.1
6.Kou Y, Jiang Y,Liu S, Yang P, Lu Y, Liu H, Li M. Regulatory T cells showed characteristics of T helper17(Th17) cells in mice periodontitis model. Oral Dis.2021 Nov 5.IF=3.8
7.Lu Y, Kou Y, Gao Y, Yang P,Liu S, Zhang F, Li M. Eldecalcitol inhibits the progression of oral cancer by suppressing the expression of GPx-1. Oral Dis. 2021 Aug 24.IF=3.8
8.Yang P, Li C, Kou Y, Jiang Y, Li D,Liu S, Lu Y, Hasegawa T, Li M. Notum suppresses the osteogenic differentiation of periodontal ligament stem cells through the Wnt/Beta catenin signaling pathway. Arch Oral Biol. 2021 Jul 21.IF=2.2
9.Yang P, Feng W, Li C, Kou Y, Li D,Liu S, Hasegawa T, Li M. LPS induces fibroblast-like synoviocytes RSC-364 cells to pyroptosis through NF-κB mediated dual signaling pathway. J Mol Histol. 2021 Jun 3.IF=2.9
10. Li D, Kou Y, Gao Y,Liu S, Yang P, Hasegawa H, Su R, Guo J, Li M: Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS. Aging-US, 2021 Jan 20;12.IF=3.9