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观察布地奈德和硫酸特布他林联合雾化吸入治疗婴幼儿毛细支气管炎的临床有效性。
纳入的病例资料来源于巨野县人民医院于2018年1月—2019年12月收治的毛细支气管炎患儿，共60例，随机分为观察组与对照组，每组各30例，对照组行常规治疗，观察组治疗方案为布地奈德联合硫酸特布他林雾化吸入。比较两组患儿临床症状消失时间、治疗前后炎症因子水平变化情况及治疗效果。
观察组与对照组患儿在咳嗽、憋喘、呼吸困难以及肺部哮鸣音症状消失时间方面的差异有统计学意义（P < 0.05）；两组患儿TNF-α、IL-6、IL-8等炎症因子水平经过治疗均降低，与治疗前比较，差异有统计学意义（P < 0.05），治疗后观察组各项指标较对照组低，差异有统计学意义（P < 0.05）；观察组较对照组总体有效率高（93.3% VS 70.0%），差异有统计学意义（P < 0.05）。
布地奈德联合硫酸特布他林雾化吸入治疗婴幼儿毛细支气管炎，对患儿炎症因子水平改善显著，有利于加快症状消失，效果可靠，值得临床推广。
| 1 | 杨丽， 金英姬， 张亚明. 布地奈德联合沙丁胺醇治疗婴幼儿毛细支气管炎的临床观察［J］. 中国药房， 2017， 28（20）： 2817. |
| 2 | 李双全， 王建忠， 杨帆， 等. 布地奈德联合特布他林治疗婴幼儿毛细支气管炎对肺功能及再次喘息的影响［J］. 儿科药学杂志， 2018， 24（6）： 25. |
| 3 | 郑茗贞， 孙奉朝， 黄国栋， 等. 布地奈德联合维生素D3治疗小儿哮喘的疗效观察及对外周血IgE、TSLP和TLRs水平的影响［J］. 当代医学， 2019， 25（6）： 10. |
| 4 | 欧有平. 孟鲁斯特钠联合布地奈德和复方异丙托溴铵治疗婴幼儿毛细支气管炎的疗效观察［J］. 现代药物与临床， 2016， 31（3）： 375. |
| 5 | 王何玲， 刘瑜娜， 赵妍. 沙丁胺醇与布地奈德雾化吸入辅助治疗毛细支气管炎104例疗效观察［J］. 中国药物与临床， 2018， 18（6）： 1018. |
| 6 | 郝凤清. 布地奈德联合特布他林雾化吸入治疗毛细支气管炎疗效观察［J］. 中国药物与临床， 2018， 18（3）： 451. |
| 7 | 江瑞娟. 布地奈德联合特布他林雾化吸入治疗婴幼儿毛细支气管炎的疗效及对肺功能、炎症因子水平的影响［J］. 哈尔滨医药， 2018， 38（5）： 433. |
| 8 | 王华. 布地奈德、特布他林、溴化异托品联合雾化治疗毛细支气管炎疗效观察［J］. 中国地方病防治杂志， 2017， 32（9）：1061. |
| 9 | 邓健， 陶威， 温利敏. 雾化吸入布地奈德对毛细支气管炎患儿反复喘息的影响［J］. 深圳中西医结合杂志， 2020， 30（21）： 124. |
| 10 | 陈强. 孟鲁司特联合布地奈德对呼吸道合胞病毒感染毛细支气管炎患儿血清炎性因子及免疫功能的影响［J］. 临床合理用药杂志， 2020， 13（18）： 50. |
| 11 | 彭叶， 郑兴群， 陈小凤. 布地奈德氧气雾化吸入联合机械辅助排痰治疗小儿毛细支气管炎的疗效观察［J］. 临床合理用药杂志， 2020， 13（23）： 82. |
| 12 | 屈林林， 张军， 唐斌. 沙丁胺醇与布地奈德联合雾化吸入治疗小儿毛细支气管炎的临床观察［J］. 当代医学， 2019， 25（36）： 28. |
| 13 | 陈荣钦. 盐酸氨溴索、布地奈德辅助治疗小儿毛细支气管炎的效果对比［J］. 黑龙江医药， 2019， 32（5）： 1057. |
| 14 | 汤磊， 赵艳. 氧气驱动雾化吸入布地奈德与乙酰半胱氨酸联合治疗小儿毛细支气管炎的疗效观察［J］. 中国医院用药评价与分析， 2019， 19（5）： 579. |
| 15 | 陈慧妙， 何剑邦. 布地奈德治疗毛细支气管炎的效果及对炎性因子的调节作用［J］. 现代实用医学， 2018， 30（1）： 56. |
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A total of 60 infants with bronchiolitis were included from January 2018 to December 2019. They were randomly divided into the observation group and the control group， with 30 cases in each. The control group received routine treatment while the observation group received budesonide combined with terbutaline sulfate atomization inhalation. The time of disappearance of clinical symptoms， the changes of inflammatory factors before and after treatment and the therapeutic effect were compared between the two groups.
There were significant differences in the disappearance time of cough， wheezing， dyspnea and lung wheezing between the observation group and the control group （P < 0.05）； TNF in children-α， the levels of IL-6 and IL-8 inflammatory factors decreased after treatment. Compared with those before the treatment， the difference was statistically significant （P < 0.05）. The indexes of the observation group were lower than those of the control group （P < 0.05）； The total effective rate of the observation group was higher than that of the control group （93.3% vs 70.0%）， and the difference was statistically significant （P < 0.05）.
Budesonide combined with terbutaline sulfate atomization inhalation in the treatment of infant bronchiolitis can significantly improve the level of inflammatory factors in children and is beneficial to accelerate the disappearance of symptoms. The effect is reliable and worthy of clinical promotion.
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Clinical efficacy of budesonide combined with terbutaline sulfate in the treatment of infant bronchiolitis by nebulization inhalation
Wenyu Peng
Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences››2021, Vol. 42››Issue (11): 853-856.
PDF(546 KB)
PDF(546 KB)
Clinical efficacy of budesonide combined with terbutaline sulfate in the treatment of infant bronchiolitis by nebulization inhalation
To observe the clinical efficacy of budesonide combined with terbutaline sulfate in the treatment of infant bronchiolitis.
A total of 60 infants with bronchiolitis were included from January 2018 to December 2019. They were randomly divided into the observation group and the control group， with 30 cases in each. The control group received routine treatment while the observation group received budesonide combined with terbutaline sulfate atomization inhalation. The time of disappearance of clinical symptoms， the changes of inflammatory factors before and after treatment and the therapeutic effect were compared between the two groups.
There were significant differences in the disappearance time of cough， wheezing， dyspnea and lung wheezing between the observation group and the control group （P< 0.05）； TNF in children-α， the levels of IL-6 and IL-8 inflammatory factors decreased after treatment. Compared with those before the treatment， the difference was statistically significant （P< 0.05）. The indexes of the observation group were lower than those of the control group （P< 0.05）； The total effective rate of the observation group was higher than that of the control group （93.3% vs 70.0%）， and the difference was statistically significant （P< 0.05）.
Budesonide combined with terbutaline sulfate atomization inhalation in the treatment of infant bronchiolitis can significantly improve the level of inflammatory factors in children and is beneficial to accelerate the disappearance of symptoms. The effect is reliable and worthy of clinical promotion.
budesonide/terbutaline sulfate/atomization inhalation/bronchiolitis of infants and children/inflammatory cytokines
| 1 | 杨丽， 金英姬， 张亚明. 布地奈德联合沙丁胺醇治疗婴幼儿毛细支气管炎的临床观察［J］. 中国药房， 2017， 28（20）： 2817. |
| 2 | 李双全， 王建忠， 杨帆， 等. 布地奈德联合特布他林治疗婴幼儿毛细支气管炎对肺功能及再次喘息的影响［J］. 儿科药学杂志， 2018， 24（6）： 25. |
| 3 | 郑茗贞， 孙奉朝， 黄国栋， 等. 布地奈德联合维生素D3治疗小儿哮喘的疗效观察及对外周血IgE、TSLP和TLRs水平的影响［J］. 当代医学， 2019， 25（6）： 10. |
| 4 | 欧有平. 孟鲁斯特钠联合布地奈德和复方异丙托溴铵治疗婴幼儿毛细支气管炎的疗效观察［J］. 现代药物与临床， 2016， 31（3）： 375. |
| 5 | 王何玲， 刘瑜娜， 赵妍. 沙丁胺醇与布地奈德雾化吸入辅助治疗毛细支气管炎104例疗效观察［J］. 中国药物与临床， 2018， 18（6）： 1018. |
| 6 | 郝凤清. 布地奈德联合特布他林雾化吸入治疗毛细支气管炎疗效观察［J］. 中国药物与临床， 2018， 18（3）： 451. |
| 7 | 江瑞娟. 布地奈德联合特布他林雾化吸入治疗婴幼儿毛细支气管炎的疗效及对肺功能、炎症因子水平的影响［J］. 哈尔滨医药， 2018， 38（5）： 433. |
| 8 | 王华. 布地奈德、特布他林、溴化异托品联合雾化治疗毛细支气管炎疗效观察［J］. 中国地方病防治杂志， 2017， 32（9）：1061. |
| 9 | 邓健， 陶威， 温利敏. 雾化吸入布地奈德对毛细支气管炎患儿反复喘息的影响［J］. 深圳中西医结合杂志， 2020， 30（21）： 124. |
| 10 | 陈强. 孟鲁司特联合布地奈德对呼吸道合胞病毒感染毛细支气管炎患儿血清炎性因子及免疫功能的影响［J］. 临床合理用药杂志， 2020， 13（18）： 50. |
| 11 | 彭叶， 郑兴群， 陈小凤. 布地奈德氧气雾化吸入联合机械辅助排痰治疗小儿毛细支气管炎的疗效观察［J］. 临床合理用药杂志， 2020， 13（23）： 82. |
| 12 | 屈林林， 张军， 唐斌. 沙丁胺醇与布地奈德联合雾化吸入治疗小儿毛细支气管炎的临床观察［J］. 当代医学， 2019， 25（36）： 28. |
| 13 | 陈荣钦. 盐酸氨溴索、布地奈德辅助治疗小儿毛细支气管炎的效果对比［J］. 黑龙江医药， 2019， 32（5）： 1057. |
| 14 | 汤磊， 赵艳. 氧气驱动雾化吸入布地奈德与乙酰半胱氨酸联合治疗小儿毛细支气管炎的疗效观察［J］. 中国医院用药评价与分析， 2019， 19（5）： 579. |
| 15 | 陈慧妙， 何剑邦. 布地奈德治疗毛细支气管炎的效果及对炎性因子的调节作用［J］. 现代实用医学， 2018， 30（1）： 56. |
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