zwang@sdfmu.edu.cn
周娜，E-mail： zhounasdu@126.com。
"],"authorList":[{"zuoZheDiZhiL_cn":["Graduate Department of Shandong First Medical University 【-逻*辑*与-】amp; Shandong Academy of Medical Sciences，Jinan 250117，China ;"],"deceased":false,"name_cn":"李雪","zuoZheDiZhiL_en":["null;"],"name_en":"Xue LI"},{"zuoZheDiZhiL_cn":["甘肃医学院附属医院眼科，甘肃 平凉 744000 ;"],"deceased":false,"name_cn":"景蕊霞","zuoZheDiZhiL_en":["Department of Ophthalmology，Affiliated Hospital of Gansu Medical College，Pingliang 744000，China ;"],"name_en":"Ruixia JING"},{"zuoZheDiZhiL_cn":["betway必威登陆网址 附属中心医院眼科，山东 济南 250013 ;"],"deceased":false,"name_cn":"王振","email":"zwang@sdfmu.edu.cn","zuoZheDiZhiL_en":["Department of Ophthalmology，Central Hospital Affiliated to Shandong First Medical University，Jinan 250013，China ;"],"name_en":"Zhen WANG"},{"zuoZheDiZhiL_cn":["betway必威登陆网址 附属省立医院检验科，山东 济南 250001 ;"],"deceased":false,"name_cn":"周娜","email":"zhounasdu@126.com","zuoZheDiZhiL_en":["Department of Clinical Laboratory，Provincial Hospital Affiliated to Shandong First Medical University，Jinan 250001，China ;"],"name_en":"Na ZHOU"}],"affList_en":["1.Graduate Department of Shandong First Medical University & Shandong Academy of Medical Sciences，Jinan 250117，China
2.Department of Ophthalmology，Affiliated Hospital of Gansu Medical College，Pingliang 744000，China
3.Department of Ophthalmology，Central Hospital Affiliated to Shandong First Medical University，Jinan 250013，China
4.Department of Clinical Laboratory，Provincial Hospital Affiliated to Shandong First Medical University，Jinan 250001，China"],"fundList_cn":["山东省自然科学基金(ZR2023MH157)"],"affList_cn":["1.betway必威登陆网址 （betway.com ）研究生部，山东 济南 250117
2.甘肃医学院附属医院眼科，甘肃 平凉 744000
3.betway必威登陆网址 附属中心医院眼科，山东 济南 250013
4.betway必威登陆网址 附属省立医院检验科，山东 济南 250001"],"article":{"keywordList_cn":["糖尿病性黄斑水肿","抗血管内皮生长因子","中心凹下脉络膜厚度","脉络膜血管指数"],"juan":"45","zhaiyao_cn":"

糖尿病性黄斑水肿（diabetic macular edema，DME）是糖尿病性视网膜病变（diabetic retinopathy，DR）的一种表现，可以发生在DR的任何阶段，是导致DR患者视力丧失最常见的原因之一。脉络膜血管是黄斑中心凹唯一的血供来源，其结构改变会损害视网膜功能。常用的脉络膜生物学标志物包括中心凹下脉络膜厚度（subfoveal choroidal thickness，SFCT）、脉络膜血管指数（choroidal vascularity index，CVI）。SFCT和CVI反映了脉络膜血管的变化情况，尤其是CVI，在监测DME进展、评估预后等方面拥有巨大的应用前景。深入理解基线脉络膜特征以及抗血管内皮生长因子（vascular endothelial growth factor，VEGF）治疗后脉络膜血管的变化，对于评估DME的治疗效果和疾病预后具有重要的指导意义。

","endNoteUrl_en":"http://xuebao.sdfmu.edu.cn/EN/article/getTxtFile.do?fileType=EndNote&id=726","reference":"
1 孙辉， 杭洪霞. 空腹血糖调节受损老年患者的社区健康管理效果［J］. betway必威登陆网址 （betway.com ）学报， 2022， 43（7）： 529.
2 胡菲菲， 辛静昕， 张新焕. miRNA对糖尿病脑病的临床意义［J］. betway必威登陆网址 （betway.com ）学报， 2022， 43（2）： 148.
3 Cui YY， Feng DF， Wu CL， et al. Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with and without macular edema： single-center cross-sectional analysis［J］. Front Endocrinol （Lausanne）， 2024， 14： 1275200.
4 Im JHB， Jin YP， Chow R， et al. Prevalence of diabetic macular edema based on optical coherence tomography in people with diabetes： a systematic review and meta-analysis［J］. Surv Ophthalmol， 2022， 67（4）： 1244.
5 Dou NX， Li GY， Fang D， et al. Association between choroidopathy and photoreceptors during the early stage of diabetic retinopathy： a cross-sectional study［J］. Graefes Arch Clin Exp Ophthalmol， 2024， 262（4）： 1121.
6 Qi ZH， Si YY， Feng F， et al. Analysis of retinal and choroidal characteristics in patients with early diabetic retinopathy using WSS-OCTA［J］. Front Endocrinol （Lausanne）， 2023， 14： 1184717.
7 Campos A， Campos EJ， Martins J， et al. Viewing the choroid： where we stand， challenges and contradictions in diabetic retinopathy and diabetic macular oedema［J］. Acta Ophthalmol， 2017， 95（5）： 446.
8 Wells JA， Glassman AR， Ayala AR， et al. Aflibercept， bevacizumab， or ranibizumab for diabetic macular edema： two-year results from a comparative effectiveness randomized clinical trial［J］. Ophthalmology， 2016， 123（6）： 1351.
9 Glassman AR， Wells JA 3rd， Josic K， et al. Five-year outcomes after initial aflibercept， bevacizumab， or ranibizumab treatment for diabetic macular edema （protocol T extension study）［J］. Ophthalmology， 2020， 127（9）： 1201.
10 Pessoa B， Marques JH， Leite J， et al. Choroidal blood flow after intravitreal ranibizumab in vitrectomized and non-vitrectomized eyes with diabetic macular edema［J］. Clin Ophthalmol， 2021， 15： 4081.
11 Yiu G， Manjunath V， Chiu SJ， et al. Effect of anti-vascular endothelial growth factor therapy on choroidal thickness in diabetic macular edema［J］. Am J Ophthalmol， 2014， 158（4）： 745.
12 Okamoto M， Yamashita M， Ogata N. Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema［J］. Graefes Arch Clin Exp Ophthalmol， 2018， 256（5）： 885.
13 Gupta C， Tan R， Mishra C， et al. Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-a novel OCT based imaging biomarker［J］. PLoS One， 2018， 13（12）： e0207435.
14 Hormel TT， Hwang TS， Bailey ST， et al. Artificial intelligence in OCT angiography［J］. Prog Retin Eye Res， 2021， 85： 100965.
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18 Abadia B， Bartol-Puyal FDA， Calvo P， et al. Mapping choroidal thickness in patients with type 2 diabetes［J］. Can J Ophthalmol， 2020， 55（1）： 45.
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20 Endo H， Kase S， Ito Y， et al. Relationship between choroidal structure and duration of diabetes［J］. Graefes Arch Clin Exp Ophthalmol， 2019， 257（6）： 1133.
21 Tang Q， Buonfiglio F， B?hm EW， et al. Diabetic retinopathy： new treatment approaches targeting redox and immune mechanisms［J］. Antioxidants （Basel）， 2024， 13（5）： 594.
22 Tang L， Xu GT， Zhang JF. Inflammation in diabetic retinopathy： possible roles in pathogenesis and potential implications for therapy［J］. Neural Regen Res， 2023， 18（5）： 976.
23 Ferrara D， Waheed NK， Duker JS. Investigating the choriocapillaris and choroidal vasculature with new optical coherence tomography technologies［J］. Prog Retin Eye Res， 2016， 52： 130.
24 Lutty GA. Diabetic choroidopathy［J］. Vision Res， 2017， 139： 161.
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32 Campochiaro PA， Wykoff CC， Shapiro H， et al. Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema［J］. Ophthalmology， 2014， 121（9）： 1783.
33 Endo H， Kase S， Takahashi M， et al. Relationship between diabetic macular edema and choroidal layer thickness［J］. PLoS One， 2020， 15（1）： e0226630.
34 Kim JT， Lee DH， Joe SG， et al. Changes in choroidal thickness in relation to the severity of retinopathy and macular edema in type 2 diabetic patients［J］. Invest Ophthalmol Vis Sci， 2013， 54（5）： 3378.
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41 Wang W， Liu S， Qiu ZH， et al. Choroidal thickness in diabetes and diabetic retinopathy： a swept source OCT study［J］. Invest Ophthalmol Vis Sci， 2020， 61（4）： 29.
42 Tan CS， Ouyang YL， Ruiz H， et al. Diurnal variation of choroidal thickness in normal， healthy subjects measured by spectral domain optical coherence tomography［J］. Invest Ophthalmol Vis Sci， 2012， 53（1）： 261.
43 Singh SR， Vupparaboina KK， Goud A， et al. Choroidal imaging biomarkers［J］. Surv Ophthalmol， 2019， 64（3）： 312.
44 Keskin ?， Dilek?i E N A， ü?gül A Y， et al. Choroidal vascularity index as a predictor for the development of retinopathy in diabetic patients［J］. J Endocrinol Invest， 2024， 47（5）： 1175.
45 Xu FB， Li ZW， Yang XY， et al. Assessment of choroidal structural changes in patients with pre-and early-stage clinical diabetic retinopathy using wide-field SS-OCTA［J］. Front Endocrinol （Lausanne）， 2023， 13： 1036625.
46 Nagaoka T， Kitaya N， Sugawara R， et al. Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes［J］. Br J Ophthalmol， 2004， 88（8）： 1060.
47 Wang JC， Laíns I， Providência J， et al. Diabetic choroidopathy： choroidal vascular density and volume in diabetic retinopathy with swept-source optical coherence tomography［J］. Am J Ophthalmol， 2017， 184： 75.
48 Mathis T， Mendes M， Dot C， et al. Increased choroidal thickness： a new indicator for monitoring diabetic macular oedema recurrence［J］. Acta Ophthalmol， 2020， 98（8）： e968.
49 Pieramici DJ， Rabena MD. Anti-VEGF therapy： comparison of current and future agents［J］. Eye （Lond）， 2008， 22（10）： 1330.
50 Fukumura D， Gohongi T， Kadambi A， et al. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability［J］. Proc Natl Acad Sci U S A， 2001， 98（5）： 2604.
51 Moradian S， Soheilian M， Asadi M， et al. Ziv-aflibercept in diabetic macular edema： relation of subfoveal choroidal thickness with visual and anatomical outcomes［J］. J Ophthalmic Vis Res， 2023， 18（2）： 164.
52 Dou NX， Yu SS， Tsui CK， et al. Choroidal vascularity index as a biomarker for visual response to antivascular endothelial growth factor treatment in diabetic macular edema［J］. J Diabetes Res， 2021， 2021： 3033219.
53 Campos A， Campos EJ， do Carmo A， et al. Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema［J］. Graefes Arch Clin Exp Ophthalmol， 2018， 256（10）： 1857.
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","bibtexUrl_cn":"//www.pitakata.com/xuebao/CN/article/getTxtFile.do?fileType=BibTeX&id=726","articleType":"research-article","abstractUrl_en":"http://xuebao.sdfmu.edu.cn/EN/10.3969/j.issn.2097-0005.2024.12.011","qi":"12","id":726,"nian":2024,"bianHao":"1734670658647-909665290","zuoZheEn_L":"Xue LI, Ruixia JING, Zhen WANG, Na ZHOU","juanUrl_en":"http://xuebao.sdfmu.edu.cn/EN/Y2024","shouCiFaBuRiQi":"2024-12-20","qiShiYe":"764","received":"2024-07-15","qiUrl_cn":"http://xuebao.sdfmu.edu.cn/CN/Y2024/V45/I12","lanMu_cn":"综述","pdfSize":"428","zuoZhe_CN":"李雪1, 景蕊霞2, 王振3(), 周娜4()","risUrl_cn":"//www.pitakata.com/xuebao/CN/article/getTxtFile.do?fileType=Ris&id=726","title_cn":"脉络膜血管生物标志物在糖尿病性黄斑水肿中的应用研究进展","doi":"10.3969/j.issn.2097-0005.2024.12.011","jieShuYe":"768","keywordList_en":["diabetic macular edema","anti-vascular endothelial growth factor","subfoveal choroidal thickness","choroidal vascularity index"],"endNoteUrl_cn":"//www.pitakata.com/xuebao/CN/article/getTxtFile.do?fileType=EndNote&id=726","zhaiyao_en":"

Diabetic macular edema （DME） is a manifestation of diabetic retinopathy （DR）， which can occur at any stage of DR and is one of the most common causes of vision loss in patients with DR. The choroid is the only source of blood supply to the macular fovea， so choroidal abnormalities can damage retinal function. The commonly used choroidal biomarkers are subfoveal choroidal thickness （SFCT） and choroidal vascularity index （CVI）. SFCT and CVI reflect the choroidal blood flow， especially CVI， which has a great application prospect in monitoring the progress of DME and evaluating the prognosis. Understanding the baseline choroidal characteristics and the changes of choroidal vessels after anti-vascular endothelial growth factor （VEGF） treatment has important guiding significance for evaluating the therapeutic effect and prognosis of DME.

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周娜，E-mail： zhounasdu@126.com。
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Research progress of choroidal vascular biomarkers in diabetic macular edema

Xue LI, Ruixia JING, Zhen WANG, Na ZHOU

Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences››2024, Vol. 45››Issue (12): 764-768.

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PDF(428 KB)
Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences ›› 2024, Vol. 45 ›› Issue (12) : 764-768. DOI: 10.3969/j.issn.2097-0005.2024.12.011
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Research progress of choroidal vascular biomarkers in diabetic macular edema

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    Abstract

    Diabetic macular edema （DME） is a manifestation of diabetic retinopathy （DR）， which can occur at any stage of DR and is one of the most common causes of vision loss in patients with DR. The choroid is the only source of blood supply to the macular fovea， so choroidal abnormalities can damage retinal function. The commonly used choroidal biomarkers are subfoveal choroidal thickness （SFCT） and choroidal vascularity index （CVI）. SFCT and CVI reflect the choroidal blood flow， especially CVI， which has a great application prospect in monitoring the progress of DME and evaluating the prognosis. Understanding the baseline choroidal characteristics and the changes of choroidal vessels after anti-vascular endothelial growth factor （VEGF） treatment has important guiding significance for evaluating the therapeutic effect and prognosis of DME.

    Key words

    diabetic macular edema/anti-vascular endothelial growth factor/subfoveal choroidal thickness/choroidal vascularity index

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    Xue LI, Ruixia JING, Zhen WANG, Na ZHOU.Research progress of choroidal vascular biomarkers in diabetic macular edema[J]. Journal of ShanDong First Medical University&ShanDong Academy of Medical Sciences. 2024, 45(12): 764-768 https://doi.org/10.3969/j.issn.2097-0005.2024.12.011

    References

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    2 胡菲菲， 辛静昕， 张新焕. miRNA对糖尿病脑病的临床意义［J］.betway必威登陆网址 （betway.com ）学报，2022，43（2）： 148.
    3 Cui YY， Feng DF， Wu CL， et al. Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with and without macular edema： single-center cross-sectional analysis［J］.Front Endocrinol （Lausanne），2024，14： 1275200.
    4 Im JHB， Jin YP， Chow R， et al. Prevalence of diabetic macular edema based on optical coherence tomography in people with diabetes： a systematic review and meta-analysis［J］.Surv Ophthalmol，2022，67（4）： 1244.
    5 Dou NX， Li GY， Fang D， et al. Association between choroidopathy and photoreceptors during the early stage of diabetic retinopathy： a cross-sectional study［J］.Graefes Arch Clin Exp Ophthalmol，2024，262（4）： 1121.
    6 Qi ZH， Si YY， Feng F， et al. Analysis of retinal and choroidal characteristics in patients with early diabetic retinopathy using WSS-OCTA［J］.Front Endocrinol （Lausanne），2023，14： 1184717.
    7 Campos A， Campos EJ， Martins J， et al. Viewing the choroid： where we stand， challenges and contradictions in diabetic retinopathy and diabetic macular oedema［J］.Acta Ophthalmol，2017，95（5）： 446.
    8 Wells JA， Glassman AR， Ayala AR， et al. Aflibercept， bevacizumab， or ranibizumab for diabetic macular edema： two-year results from a comparative effectiveness randomized clinical trial［J］.Ophthalmology，2016，123（6）： 1351.
    9 Glassman AR， Wells JA 3rd， Josic K， et al. Five-year outcomes after initial aflibercept， bevacizumab， or ranibizumab treatment for diabetic macular edema （protocol T extension study）［J］.Ophthalmology，2020，127（9）： 1201.
    10 Pessoa B， Marques JH， Leite J， et al. Choroidal blood flow after intravitreal ranibizumab in vitrectomized and non-vitrectomized eyes with diabetic macular edema［J］.Clin Ophthalmol，2021，15： 4081.
    11 Yiu G， Manjunath V， Chiu SJ， et al. Effect of anti-vascular endothelial growth factor therapy on choroidal thickness in diabetic macular edema［J］.Am J Ophthalmol，2014，158（4）： 745.
    12 Okamoto M， Yamashita M， Ogata N. Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema［J］.Graefes Arch Clin Exp Ophthalmol，2018，256（5）： 885.
    13 Gupta C， Tan R， Mishra C， et al. Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-a novel OCT based imaging biomarker［J］.PLoS One，2018，13（12）： e0207435.
    14 Hormel TT， Hwang TS， Bailey ST， et al. Artificial intelligence in OCT angiography［J］.Prog Retin Eye Res，2021，85： 100965.
    15 Cheung CMG， Fawzi A， Teo KY， et al. Diabetic macular ischaemia - a new therapeutic target？［J］.Prog Retin Eye Res，2022，89： 101033.
    16 Peng SY， Chen TC， Hsieh YT， et al. Choroidal changes in patients with diabetic retinopathy： a retrospective study［J］.Diagnostics （Basel），2024，14（5）： 537.
    17 Agrawal R， Gupta P， Tan KA， et al. Choroidal vascularity index as a measure of vascular status of the choroid： measurements in healthy eyes from a population-based study［J］.Sci Rep，2016，6： 21090.
    18 Abadia B， Bartol-Puyal FDA， Calvo P， et al. Mapping choroidal thickness in patients with type 2 diabetes［J］.Can J Ophthalmol，2020，55（1）： 45.
    19 Muir ER， Rentería RC， Duong TQ. Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes［J］.Invest Ophthalmol Vis Sci，2012，53（10）： 6488.
    20 Endo H， Kase S， Ito Y， et al. Relationship between choroidal structure and duration of diabetes［J］.Graefes Arch Clin Exp Ophthalmol，2019，257（6）： 1133.
    21 Tang Q， Buonfiglio F， B?hm EW， et al. Diabetic retinopathy： new treatment approaches targeting redox and immune mechanisms［J］.Antioxidants （Basel），2024，13（5）： 594.
    22 Tang L， Xu GT， Zhang JF. Inflammation in diabetic retinopathy： possible roles in pathogenesis and potential implications for therapy［J］.Neural Regen Res，2023，18（5）： 976.
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