关键词: 肝细胞癌, T细胞, NK细胞

Abstract: Objective: To investigate the changes of T cells and NK cells in peripheral blood of patients with primary hepatocellular carcinoma (HCC) and their relationship with cancer.Methods: T cells and NK cells in peripheral venous blood of 28 patients with primary hepatocellular carcinoma, 29 patients with chronic liver cirrhosis, and 31 healthy adults were analyzed to study their relationship with tumor flight.Results: In the peripheral venous blood of patients with primary liver cancer, the levels of CD3⁺ T cells, CD4⁺ T cells, and NK cells were significantly lower than those of patients with chronic liver cirrhosis and healthy adults, and the difference was statistically significant (P＜0.05); the level of CD8⁺ T cells was significantly higher than that of the patients with chronic liver cirrhosis and healthy adult and the difference was statistically significant (P﹤0.05). In the peripheral venous blood of patients with primary liver cancer, there was no significant difference in the levels of CD3⁺ T cells, CD4⁺ T cells, CD8⁺ T, and NK cells in patients with stage I and II (P>0.05); CD3⁺ T cells, CD4⁺ T in patients with stage III were lower than those of stage I and II patients. The levels of cells and NK cells were significantly lower than those of stage I and II patients, and the levels of CD8⁺ T cells were significantly higher than those of stage I and II patients. The difference was statistically significant (P<0.05).Conclusion: The changes of peripheral venous blood T cell and NK cell levels in patients with primary hepatocellular carcinoma reflect the immune state of the body, and may be closely related to the occurrence of tumor, which is of great clinical significance in judging the condition and prognosis of patients with hepatocellular carcinoma.

Key words: hepatocellular carcinoma, T cells, NK cells