The clinical data of 102 patients with cholecystolithiasis complicated with choledocholithiasis were retrospectively analyzed，among which 50 patients underwent open surgery （control group） and 52 patients underwent laparoscopic choledocholithiasis （observation group）. The surgical conditions，changes in the body stress response， postoperative complications and recurrence of the two groups were compared.

Compared with the control group， the operation time， hospital stay and gastrointestinal function recovery time in the observation group were significantly shortened， the amount of intraoperative blood loss was significantly reduced， postoperative pain relief was more obvious，and the pain VAS score 1d after surgery was significantly decreased （P < 0.05）. The serum levels of TNF-α and CRP were increased on postoperative day 1，and the degree of increase was more obvious in the control group than in the observation group （P < 0.05）. The serum levels of TNF-α and CRP in 2 groups were significantly decreased on day 7 after operation，and the degree of decrease in the observation group was more obvious （P < 0.05）. The incidence of postoperative complications in the observation group and the control group were 3.85% （2/52） and 20.00% （10/50） respectively， with fewer complications in the observation group （P < 0.05）. No recurrence was observed in the observation group，and the recurrence rate in the control group was significantly increased （P < 0.05）.

The treatment of cholecystolithiasis combined with choledocholithiasis by laparoscopy combined with choledochoscopy is more effective，which is beneficial to reduce trauma， relieve postoperative pain， reduce postoperative stress reaction and have fewer complications.