betway必威登陆网址 （betway.com ）学报 ›› 2021, Vol. 42 ›› Issue (5): 347-357.DOI: 10.3969/j.issn.2097-0005.2021.05.005
王新, 陈正涛, 唐华
收稿日期:2021-01-22
出版日期:2021-05-25
发布日期:2021-08-31
通讯作者:
唐华,E-mail:tanghuazhang218@163.com。
作者简介:王新,硕士研究生,研究方向:细胞免疫,E-mail:13038092719@163.com;陈正涛,讲师,研究方向:黏膜免疫,E-mail:cztd_666@163.com。王新和陈正涛为共同第一作者。唐华,二级教授, 浙江大学肿瘤学博士,美国EMORY大学博士后,中国免疫学会会员,山东免疫学会第六届常务理事。山东省引进海外高层次创新人才、泰山学者海外特聘专家、山东省有突出贡献的中青年专家、山东省留学人员回国创业奖获得者。多年来从事树突状细胞的研究,特别关注该细胞对获得性免疫的调控在人类重大免疫相关性疾病中的作用。2010年底回国到betway必威登陆网址
泰安校区(原泰山医学院)组建研究团队,2021年被聘为betway必威登陆网址
医学科技创新中心PI。指导团队累计获得24项国家级课题,其中包括其本人主持的“973”课题1项、国家自然科学基金重大研究计划1项和国家自然科学基金面上项目3项。获国家发明专利2项,以第一作者或通讯作者在Nature Immunology、Nature Communications、Blood、Cancer Letters、eBiomedicine等杂志上发表SCI论文多篇。
基金资助:Wang Xin, Chen Zhengtao, Tang Hua
Received:2021-01-22
Online:2021-05-25
Published:2021-08-31
摘要： 固有淋巴细胞(innate lymphoid cells,ILCs)是十多年前才发现的免疫系统“新兵”,是一类新型固有免疫细胞,是免疫系统的重要组成部分。它们在调节机体组织区域免疫反应和稳态维持方面发挥重要作用。根据ILCs表达的转录因子和分泌的细胞因子的不同可以将其分为三个不同类群:ILC1s、ILC2s以及ILC3s。其中ILC3s主要存在于肠道,并通过参与促进淋巴器官形成、维持上皮屏障完整、调节肠道炎症、促进抗菌反应等方面来维持肠道黏膜区域免疫的稳态。本文将对ILC3s的发育、特性以及在肠道区域免疫系统中的病理生理功能做一综述,概括当前ILC3s的主要研究进展。
中图分类号:
王新, 陈正涛, 唐华. 肠道3型固有淋巴细胞研究进展[J]. betway必威登陆网址 （betway.com ）学报, 2021, 42(5): 347-357.
Wang Xin, Chen Zhengtao, Tang Hua. Research progress of intestinal type 3 innate lymphoid cells[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(5): 347-357.
| [1] Vivier E, Artis D, Colonna M, et al. Innate lymphoid cells: 10 years on[J]. Cell, 2018,174(5):1054. [2] Mackley EC, Houston S, Marriott CL, et al. CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes[J]. Nature Communications, 2015,6:5862. [3] Satoh-Takayama N, Vosshenrich CAJ, Lesjean-Pottier S, et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense[J]. Immunity, 2008,29(6):958. [4] Moro K, Yamada T, Tanabe M, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells[J]. Nature, 2010,463(7280):540. [5] Morita H, Moro K, Koyasu S. Innate lymphoid cells in allergic and nonallergic inflammation[J]. Journal of Allergy and Clinical Immunology, 2016,138(5):1253. [6] Spits H, Artis D, Colonna M, et al. Innate lymphoid cells: a proposal for uniform nomenclature[J]. Nat Rev Immunol, 2013,13(2):145. [7] Artis D, Spits H. The biology of innate lymphoid cells[J]. Nature, 2015,517(7534):293. [8] Ebihara T. Dichotomous regulation of acquired immunity by innate lymphoid cells[J]. Cells, 2020,9(5):1193. [9] Spits H, di Santo JP. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling[J]. Nature Immunology, 2011,12(1):21. [10] Eberl G. RORγt, a multitask nuclear receptor at mucosal surfaces[J]. Mucosal Immunology, 2017,10(1):27. [11] Zeng B, Shi S, Ashworth G, et al. ILC3 function as a double-edged sword in inflammatory bowel diseases[J]. Cell Death Dis, 2019,10(4):315. [12] Hepworth MR, Monticelli LA, Fung TC, et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria[J]. Nature, 2013,498(7452):113. [13] Colonna M. Innate lymphoid cells: Diversity, plasticity, and unique functions in immunity[J]. Immunity (Cambridge, Mass), 2018,48(6):1104. [14] Ibiza S, García-Cassani B, Ribeiro H, et al. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence[J]. Nature, 2016,535(7612):440. [15] Buonocore S, Ahern PP, Uhlig HH, et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology[J]. Nature, 2010,464(7293):1371. [16] Melo-Gonzalez F, Hepworth MR. Functional and phenotypic heterogeneity of group 3 innate lymphoid cells[J]. Immunology, 2017,150(3):265. [17] Adachi S, Yoshida H, Kataoka H, et al. Three distinctive steps in Peyer's patch formation of murine embryo[J]. Int Immunol, 1997,9(4):507. [18] Kelly KA, Scollay R. Seeding of neonatal lymph nodes by T cells and identification of a novel population of CD3-CD4+ cells[J]. Eur J Immunol, 1992,22(2):329. [19] Buettner M, Lochner M. Development and function of secondary and tertiary lymphoid organs in the small intestine and the colon[J]. Frontiers in Immunology, 2016,77(Suppl 10):342. [20] Cording S, Medvedovic J, Lécuyer E, et al. Mouse models for the study of fate and function of innate lymphoid cells[J]. European Journal of Immunology, 2018,48(8):1271. [21] Shiu J, Piazuelo MB, Ding H, et al. Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth[J]. Mucosal Immunology, 2015,8(5):1047. [22] Bernink JH, Krabbendam L, Germar K, et al. Interleukin-12 and -23 control plasticity of CD127+ group 1 and group 3 innate lymphoid cells in the intestinal lamina propria[J]. Immunity, 2015,43(1):146. [23] Cella M, Fuchs A, Vermi W, et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity[J]. Nature, 2009,457(7230):722. [24] Croxatto D, Micheletti A, Montaldo E, et al. Group 3 innate lymphoid cells regulate neutrophil migration and function in human decidua[J]. Mucosal Immunology, 2016,9(6):1372. [25] Hoorweg K, Peters CP, Cornelissen F, et al. Functional differences between human NKp44- and NKp44+ RORC+ innate lymphoid cells[J]. Frontiers in Immunology, 2012,3:72. [26] Klose CSN, Kiss EA, Schwierzeck V, et al. A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells[J]. Nature, 2013,494(7436):261. [27] Constantinides MG, McDonald BD, Verhoef PA, et al. A committed precursor to innate lymphoid cells[J]. Nature, 2014,508(7496):397. [28] Zook EC, Kee BL. Development of innate lymphoid cells[J]. Nature Immunology, 2016,17(7):775. [29] Serafini N, Vosshenrich CAJ, Di Santo JP. Transcriptional regulation of innate lymphoid cell fate[J]. Nature Reviews Immunology, 2015,15(7):415. [30] Yu X, Wang Y, Deng M, et al. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor[J]. ELife Sciences, 2014,3:356. [31] Cherrier M, Sawa S, Eberl G. Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells[J]. Journal of Experimental Medicine, 2012,209(4):729. [32] Satoh-Takayama N, Lesjean-Pottier S, Vieira P, et al. IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors[J]. Journal of Experimental Medicine, 2010,207(2):273. [33] Savage AK, Constantinides MG, Han J, et al. The transcription factor PLZF directs the effector program of the NKT cell lineage[J]. Immunity, 2008,29(3):391. [34] Blom B, Spits H. Development of human lymphoid cells[J]. Annu Rev Immunol, 2006,24:287. [35] Mebius RE. Organogenesis of lymphoid tissues[J]. Nature Reviews Immunology, 2003,3(4):292. [36] Ebihara T, Song C, Ryu SH, et al. Runx3 specifies lineage commitment of innate lymphoid cells[J]. Nature Immunology, 2015,16(11):1124. [37] Lee JS, Cella M, McDonald KG, et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of notch[J]. Nat Immunol, 2011,13(2):144. [38] Kiss EA, Vonarbourg C, Kopfmann S, et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles[J]. Science (American Association for the Advancement of Science), 2011,334(6062):1561. [39] Xia P, Liu J, Wang S, et al. WASH maintains NKp46+ ILC3 cells by promoting AHR expression[J]. Nature Communications, 2017,8(1):15685. [40] Kiss EA, Diefenbach A. Role of the aryl hydrocarbon receptor in controlling maintenance and functional programs of ROR gammat(+) Innate lymphoid cells and intraepithelial lymphocytes[J]. Front Immunol, 2012,3:124. [41] Possot C, Schmutz S, Chea S, et al. Notch signaling is necessary for adult, but not fetal, development of RORγt+ innate lymphoid cells[J]. Nature Immunology, 2011,12(10):949. [42] Schroeder J, Meissl K, Hromadová D, et al. T-Bet controls cellularity of intestinal group 3 innate lymphoid cells[J]. Frontiers in Immunology, 2021, 11:623324. [43] Fachi JL, Pral LP, Dos SJ, et al. Hypoxia enhances ILC3 responses through HIF-1alpha-dependent mechanism[J/OL]. Mucosal Immunol, 2021. https://doi.org/10.1038/s41385-020-00371-6.[published online January 14, 2021]. [44] Bellet MM, Deriu E, Liu JZ, et al. Circadian clock regulates the host response to Salmonella[J]. Proceedings of the National Academy of Sciences, 2013,110(24):9897. [45] Liang X, Bushman FD, FitzGerald GA. Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock[J]. Proceedings of the National Academy of Sciences, 2015,112(33):10479. [46] Tahara Y, Shibata S. Chronobiology and nutrition[J]. Neuroscience, 2013,253:78. [47] Hussain MM. Regulation of intestinal lipid absorption by clock genes[J]. Annual Review of Nutrition, 2014,34(1):357. [48] Godinho-Silva C, Domingues RG, Rendas M, et al. Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis[J]. Nature, 2019,574(7777):254. [49] Seillet C, Luong K, Tellier J, et al. The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity[J]. Nature Immunology, 2020,21(2):168. [50] Teng F, Goc J, Zhou L, et al. A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut[J]. Sci Immunol, 2019,4(40):eaax1215. [51] Wang Q, Robinette ML, Billon C, et al. Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells[J]. Science Immunology, 2019,4(40):eaay7501. [52] Asher G, Sassone-Corsi P. Time for food: The intimate interplay between nutrition, metabolism, and the circadian clock[J]. Cell (Cambridge), 2015,161(1):84. [53] Vonarbourg C, Mortha A, Bui VL, et al. Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt+ innate lymphocytes[J]. Immunity, 2010,33(5):736. [54] Bernink JH, Peters CP, Munneke M, et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues[J]. Nature Immunology, 2013,14(3):221. [55] Cella M, Gamini R, Sécca C, et al. Subsets of ILC3-LC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues[J]. Nature Immunology, 2019,20(8):980. [56] Melo-Gonzalez F, Kammoun H, Evren E, et al. Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria[J]. Journal of Experimental Medicine, 2019,216(4):728. [57] Lehmann FM, von Burg N, Ivanek R, et al. Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation[J]. Nature Communications, 2020,11(1):1794. [58] Hepworth MR, Fung TC, Masur SH, et al. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells[J]. Science, 2015,348(6238):1031. [59] Saez De Guinoa J, Jimeno R, Farhadi N, et al. CD1d-mediated activation of group 3 innate lymphoid cells drives IL-22 production[J]. EMBO Reports, 2017,18(1):39. [60] Yamano T, Dobeš J, Voboril M, et al. Aire-expressing ILC3-like cells in the lymph node display potent APC features[J]. Journal of Experimental Medicine, 2019,216(5):1027. [61] Gasteiger G, Fan X, Dikiy S, et al. Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs[J]. Science, 2015,350(6263):981. [62] Pearson C, Thornton EE, McKenzie B, et al. ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation[J]. ELife, 2016,5:e10066. [63] Emgård J, Kammoun H, García-Cassani B, et al. Oxysterol sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation[J]. Immunity, 2018,48(1):120. [64] Shikhagaie MM, Björklund ÅK, Mjösberg J, et al. Neuropilin-1 is expressed on lymphoid tissue residing LTi-like group 3 innate lymphoid cells and associated with ectopic lymphoid aggregates[J]. Cell Reports, 2017,18(7):1761. [65] Kim MH, Taparowsky EJ, Kim CH. Retinoic acid differentially regulates the migration of innate lymphoid cell subsets to the gut[J]. Immunity, 2015,43(1):107. [66] Chu C, Moriyama S, Li Z, et al. Anti-microbial functions of group 3 innate lymphoid cells in gut-associated lymphoid tissues are regulated by G-protein-coupled receptor 183[J]. Cell Reports, 2018,23(13):3750. [67] Satoh-Takayama N, Serafini N, Verrier T, et al. The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells[J]. Immunity, 2014,41(5):776. [68] McDonald KG, McDonough JS, Wang C, et al. CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles[J]. The American Journal of Pathology, 2007,170(4):1229. [69] Baptista AP, Olivier BJ, Goverse G, et al. Colonic patch and colonic SILT development are independent and differentially regulated events[J]. Mucosal Immunology, 2013,6(3):511. [70] Ardain A, Domingo-Gonzalez R, Das S, et al. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis[J]. Nature, 2019,570(7762):528. [71] Kim HY, Lee HJ, Chang Y, et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity[J]. Nature Medicine, 2014,20(1):54. [72] Willinger T. Oxysterols in intestinal immunity and inflammation[J]. Journal of Internal Medicine, 2019,285(4):367. [73] Eisenring M, Vom Berg J, Kristiansen G, et al. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46[J]. Nature Immunology, 2010,11(11):1030. [74] Carrega P, Loiacono F, Di Carlo E, et al. NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures[J]. Nature Communications, 2015,6(1):8280. [75] Shields JD, Kourtis IC, Tomei AA, et al. Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21[J]. Science, 2010,328(5979):749. [76] Irshad S, Flores-Borja F, Lawler K, et al. RORgammat(+) innate lymphoid cells promote lymph node metastasis of breast cancers[J]. Cancer Res, 2017,77(5):1083. [77] Wang W, Li Y, Hao J, et al. The interaction between lymphoid tissue Inducer-like cells and T cells in the mesenteric lymph node restrains intestinal humoral immunity[J]. Cell Reports, 2020,32(3):107936. [78] Schmutz S, Bosco N, Chappaz S, et al. Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells[J]. J Immunol, 2009,183(4):2217. [79] van de Pavert SA, Mebius RE. New insights into the development of lymphoid tissues[J]. Nature Reviews Immunology, 2010,10(9):664. [80] Kanamori Y, Ishimaru K, Nanno M, et al. Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop[J]. J Exp Med, 1996,184(4):1449. [81] Eberl G, Littman DR. Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells[J]. Science, 2004,305(5681):248. [82] Guo X, Qiu J, Tu T, et al. Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection[J]. Immunity, 2014,40(1):25. [83] Lindemans CA, Calafiore M, Mertelsmann AM, et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration[J]. Nature, 2015,528(7583):560. [84] Aparicio-Domingo P, Romera-Hernandez M, Karrich JJ, et al. Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage[J]. Journal of Experimental Medicine, 2015,212(11):1783. [85] Ebbo M, Crinier A, Vély F, et al. Innate lymphoid cells: major players in inflammatory diseases[J]. Nature Reviews Immunology, 2017,17(11):665. [86] Wang S, Xia P, Chen Y, et al. Regulatory innate lymphoid cells control innate intestinal inflammation[J]. Cell, 2017,171(1):201. [87] Sonnenberg GF, Monticelli LA, Elloso MM, et al. CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut[J]. Immunity (Cambridge, Mass.), 2011,34(1):122. [88] Zheng Y, Valdez PA, Danilenko DM, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens[J]. Nat Med, 2008,14(3):282. [89] Goto Y, Obata T, Kunisawa J, et al. Innate lymphoid cells regulate intestinal epithelial cell glycosylation[J]. Science, 2014,345(6202):1254009. [90] Qiu J, Heller JJ, Guo X, et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells[J]. Immunity, 2012,36(1):92. [91] Schiering C, Wincent E, Metidji A, et al. Feedback control of AHR signalling regulates intestinal immunity[J]. Nature, 2017,542(7640):242. [92] Pickert G, Neufert C, Leppkes M, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing[J]. Journal of Experimental Medicine, 2009,206(7):1465. [93] He L, Zhou M, Li YC. Vitamin D/Vitamin D receptor signaling is required for normal development and function of group 3 innate lymphoid cells in the gut[J]. iScience, 2019,17:119. [94] Chen J, Waddell A, Lin Y, et al. Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells[J]. Mucosal Immunology, 2015,8(3):618. [95] Chun E, Lavoie S, Fonseca-Pereira D, et al. Metabolite-sensing receptor Ffar2 regulates colonic group 3 innate lymphoid cells and gut immunity[J]. Immunity, 2019,51(5):871. [96] Spencer SP, Wilhelm C, Yang Q, et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity[J]. Science, 2014,343(6169):432. [97] Tumanov AV, Koroleva EP, Guo X, et al. Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge[J]. Cell Host & Microbe, 2011,10(1):44. [98] Gladiator A, Wangler N, Trautwein-Weidner K, et al. Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection[J]. The Journal of Immunology (1950), 2013,190(2):521. [99] Kroemer A, Cosentino C, Kaiser J, et al. Intestinal transplant inflammation: the third inflammatory bowel disease[J]. Current Gastroenterology Reports, 2016,18(11):56. [100] Muñoz M, Heimesaat MM, Danker K, et al. Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17[J]. Journal of Experimental Medicine, 2009,206(13):3047. [101] Li J, Shi W, Sun H, et al. Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation[J]. Nature Communications, 2019,10(1):3371. [102] Siakavellas SI, Bamias G. Tumor necrosis factor-like cytokine TL1A and its receptors DR3 and DcR3[J]. Inflammatory Bowel Diseases, 2015,21(10):2441. [103] Deng T, Suo C, Chang J, et al. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice[J]. Cellular & Molecular Immunology, 2020,17(2):163. [104] van de Pavert SA, Ferreira M, Domingues RG, et al. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity[J]. Nature, 2014,508(7494):123. [105] Yan J, Yu J, Yuan S, et al. Musculin is highly enriched in Th17 and IL-22-producing ILC3s and restrains pro-inflammatory cytokines in murine colitis[J]. Eur J Immunol, 2021,51(4):995. [106] Hu L, Hu J, Chen L, et al. Interleukin-22 from type 3 innate lymphoid cells aggravates lupus nephritis by promoting macrophage infiltration in lupus-prone mice[J].Front Immunol,2021,12:584414. [107] Muir R, Osbourn M, Dubois AV, et al. Innate lymphoid cells are the predominant source of IL-17A during the early pathogenesis of acute respiratory distress syndrome[J]. American Journal of Respiratory and Critical Care Medicine, 2016,193(4):407. [108] Wang S, Li J, Wu S, et al. Type 3 innate lymphoid cell: A new player in liver fibrosis progression[J]. Clinical Science, 2018,132(24):2565. [109] Starkey MR. A pulmonary ILC3 niche promotes neonatal mucosal immunity to respiratory bacterial infection and is associated with postnatal lung development[J]. Mucosal Immunol, 2020,13(3):385. [110] Darby M, Roberts LB, Mackowiak C, et al. ILC3-derived acetylcholine promotes protease-driven allergic lung pathology[J]. J Allergy Clin Immunol, 2021,147(4):1513.e4. [111] Kim HY, Lee HJ, Chang Y, et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity[J]. Nature Medicine, 2014,20(1):54. [112] Keren A, Shemer A, Ginzburg A, et al. Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin[J]. J Allergy Clin Immunol, 2018,142(1):305. [113] Villanova F, Flutter B, Tosi I, et al. Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis[J]. J Invest Dermatol, 2014,134(4):984. [114] Teunissen M, Munneke JM, Bernink JH, et al. Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients[J]. J Invest Dermatol, 2014,134(9):2351. [115] Bugaut H, Aractingi S. Major role of the IL17/23 axis in Psoriasis supports the development of new targeted therapies[J]. Front Immunol,2021,12:621956. [116] Huber S, Gagliani N, Zenewicz LA, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine[J]. Nature, 2012,491(7423):259. [117] Kirchberger S, Royston DJ, Boulard O, et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model[J]. J Exp Med, 2013,210(5):917. [118] Xuan X, Zhou J, Tian Z, et al. ILC3 cells promote the proliferation and invasion of pancreatic cancer cells through IL-22/AKT signaling[J]. Clinical and Translational Oncology, 2020,22(4):563. [119] Atreya I, Kindermann M, Wirtz S. Innate lymphoid cells in intestinal cancer development[J]. Seminars in Immunology, 2019,41:101267. [120] Wang S, Qu Y, Xia P, et al. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer[J]. Cell Res, 2020,30(7):610. [121] Gronke K, Hernandez PP, Zimmermann J, et al. Interleukin-22 protects intestinal stem cells against genotoxic stress[J]. Nature, 2019,566(7743):249. [122] Zhu Y, Shi T, Lu X, et al. Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22[J]. The EMBO Journal, 2021:e105320. [123] Che Y, Su Z, Xia L. Effects of IL-22 on cardiovascular diseases[J]. Int Immunopharmacol, 2020,81:106277. [124] Dalli J, Colas RA, Arnardottir H, et al. Vagal regulation of group 3 innate lymphoid cells and the immunoresolvent PCTR1 controls infection resolution[J]. Immunity, 2017,46(1):92. [125] Baban B, Braun M, Khodadadi H, et al. AMPK induces regulatory innate lymphoid cells after traumatic brain injury[J]. JCI Insight, 2021,6(1):e126766. |
| No related articles found! |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||
