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Table of Content

    25 June 2021, Volume 42 Issue 6
    Basic Researches
    Inhibitory effect of VEGF and Survivin antisense phosphorothioate oligodeoxynucleotides on the growth of human tongue cancer xenografts in nude mice
    Li Tengyu, Yu Xiaopeng, Li Xiaoguang, Wang Yanxiu, Li Junfu, Chen Daiyun, Sun Zhen
    2021, 42(6):  401-405.  DOI: 10.3969/j.issn.2097-0005.2021.06.001
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    Objective: To study the effect of VEGF ASODN and Survivin ASODN co transfection on Tca8113 tongue cancer cells in nude mice. Methods: 25 female nude mice were divided into 5 groups with 5 mice in each group. ①In the combined ASODN group, 66 μg survivin ASODN and 66 μg VEGF ASODN were injected into the tumor body and peritumoral area of nude mice . The volume of injection was 200 μl. It contains lipofectaminetm 2000 and serum-free 1640 solution. ②VEGF ASODN group:VEGF ASODN 66 μg was injected in the same way . ③Survivin ASODN group:survivin ASODN 66 μg was injected in the same way. ④Liposome group:the same amount of liposome 200 μl was injected in the same way. ⑤NS group:the same amount of ns 200 μl was injected.Once every 3 days, 7 times in total. Two days after the end of the experiment, the nude mice were killed under general anesthesia. The weight of the tumor was measured and the size of the tumor was measured. The tumor was made into paraffin sections. The expression levels of VEGF, survivin, PCNA and CD34 were measured by immunohistochemistry. The microvessel density (MVD) and PCNA label index (PLI) of the tumor were calculated. Results: The weight, volume, VEGF and survivin protein, PCNA and CD34 expression of xenografts in nude mice were significantly decreased in the combined ASODN group. Conclusion:Co transfection of VEGF ASODN and Survivin ASODN can significantly inhibit the expression of VEGF and Survivin, and inhibit the growth and proliferation of Tca8113 tongue cancer cells.
    Mechanism of acetylsalicylic acid combined with diclofenac in the treatment of osteoarthritis
    Hou Shenggui, Liu Jianqiang
    2021, 42(6):  406-410.  DOI: 10.3969/j.issn.2097-0005.2021.06.002
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    Objective: To study the mechanism of combination diclofenac with different concentrations of acetylsalicylic acid in rabbit osteoarthritis models. Methods: Rabbit osteoarthritis models were treated with diclofenac acetyl in accordance with different concentrations of alicylic acid. We measured the scores in articular cartilage.PCR and WB were performed to detect the expressions of MMP-3 and TIMP-1.ELASA was used to compare the NO and IL-1β in synovial fluid. Results: Different concentrations of the drug had good therapeutic effect on osteoarthritis of rabbit knee,reduced the scores and the contents of NO and IL-1β,WB method showed the expressions of MMP-3 and MMP-13 protein were down regulated,PCR found upregulation mRNA expression of TIMP-1. Conclusion: Combination of diclofenac with different concentrations of acetylsalicylic acid can relieve the pathological changes in our rabbit osteoarthritis models.The effective therapeutic regimen for osteoarthritis can be verified.The therapeutic goal for osteoarthritis models is achieved by the inhibition of NO, IL-1,MMP-3 and MMP-13 expression, accompanied by the uprugulation of TIMP-1 expression.
    Hematological evaluation of self-designed prescription for invigorating Qi and activating blood for treating Qi deficiency and blood stasis model rats
    Xu Jiawei
    2021, 42(6):  411-414.  DOI: 10.3969/j.issn.2097-0005.2021.06.003
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    Objective: To observe the changes of body weight and hematology in the model rats with Qi deficiency and blood stasis under the influence of different doses of Buqi Huoxue Prescription. Methods: 180 SPF SD rats were selected and randomly divided into groups with 30 rats in each group.The model of Qi deficiency and blood stasis was duplicated by the combined stimulation method of hunger, fatigue and cold. The rats in the blank group were fed with normal water, while the rats in the positive group were given Buyang Huanwu Decoction (1.45g/ml), Buqi Huoxue Decoction group: rats were given Buqi Huoxue Decoction by gavage at the dose of 10ml/kg. The concentration of Buqi Huoxue Decoction in high, medium and low groups were 1.25g/ml, 0.63g/ml and 0.31g/ml respectively.The hemorheology indexes of the model rats were measured by semi-automatic hemorheology after 20 days, 40 days and 60 days of modeling.Four items of coagulation were measured by automatic blood coagulation analyzer.ELISA method was used in the determination of plasma PIVKA Ⅱ, gamma - glutamate carboxylase and F1 + 2 fragment content. Results: The APTT and PT (P<0.05) were significantly shortened by high, medium and low doses of fuqi and Huoxue Decoction at 60 days.extended FIB(P<0.05); The whole blood viscosity of rats with high, medium and low shear rate was significantly increased (P<0.05;PIVKA - Ⅱ content decreased significantly in plasma (P<0.05), the contents of glutamate carboxylase and F1+2 fragment increased significantly (P<0.05). Conclusion: The prescription for invigorating Qi and activating blood circulation can improve the blood viscosity and coagulation function of rats and improve liver function, which has a good effect on hypocoagulation and blood stasis.
    Clinical Researches
    Combined treatment of senile hypertension with obesity hypertension treatment and peripheral vascular disease prevention and control of action
    Li Xingchao, Wang Youfang, Zhu Xiaosong, Zhao Yingxin, Li Jinkui, Xiang Ran, Zhang Mengmeng, Zhang Jinling, Che Fengyuan
    2021, 42(6):  415-419.  DOI: 10.3969/j.issn.2097-0005.2021.06.004
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    Objective: To observe the antihypertensive effect of combined therapy on aged patients with primary hypertension and abdominal obesity and the prevention and treatment of peripheral vascular disease. Methods: A total of 127 elderly patients were enrolled and divided into two groups, namely, the intensified therapy group (Valsartan 80 mg/d, Rosuvastatin 10 mg/d,n=65), and the valsartan treatment group (Valsartan 80 mg/d,n=62). Regular follow-up was conducted for 6 months. Results: ① After treatment,the SBP, DBP, PP, TG, TC, LDL-c and ABI of each group were significantly lower than those before (P<0.05), HDL-c and ABI were significantly higher than those before treatment (P<0.05), and the intensified therapy group was better than the valsartan group. The antihypertensive efficiency of combined antihypertensive group was higher than that of valsartan group (P<0.05).② There was interactive effect of antihypertensive and lipid lowering therapy in lowering SBP, DBP, PP, ABI and AI (P<0.05).③ Partial correlation analysis showed that there was a positive correlation between treatment method and SBP, DBP, TG, TC,ABI and AI (P<0.05). Conclusion: Combined treatment has a significant effect on hypertension and obesity in the elderly, effectively regulating blood lipid levels, fully improving the degree of peripheral vascular arteriosclerosis, and preventing and controlling the occurrence and development of arteriosclerosis diseases.
    The changes of platelet and blood calcium in patients with severe burn and their predictive effect on prognosis
    Zhang Canyong , Feng Zhang, Zang Chengyu, Wang Yibing
    2021, 42(6):  420-422.  DOI: 10.3969/j.issn.2097-0005.2021.06.005
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    Objective: To study the changes of platelet and blood calcium in patients with severe burn. Methods: The platelet count and blood calcium level of the patients were checked in tests performed at different times after admission to the ward, and the changes in the test results of each group of patients were compared. Results: The blood calcium of burn patients generally decreased, and there was a short decrease on the 4th day, and then it would rise to a relatively stable state, and the calcium of the death group on the 1, 4, 7 and 14 days The ion level was lower than that of the survival group, and the difference was statistically significant (P<0.05).The platelet counts of the death group and the survival group were not statistically significant on the first day of admission.They decreased on the 4th day and then increased. The platelet counts of the death group on the 4th, 7th, and 14th days were compared with those of the survival group The difference is statistically significant. Conclusion: The detection of platelet count and blood calcium level in patients with severe burns is beneficial for the assessment of the patient's condition and has certain clinical application value.
    The effect of auricular point sticking combined withTraditional Chinese Medicine on the curative effect and prognosis of pregnancy hypertension patients with phlegm dampness constitution
    Rong Yan, Xia Zheyuan, Shen Peijun
    2021, 42(6):  423-426.  DOI: 10.3969/j.issn.2097-0005.2021.06.006
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    Objective: To explore the effect of auricular point sticking combined with Traditional Chinese medicine on the curative effect and prognosis of pregnancy hypertension patients with phlegm dampness constitution, and to provide a theoretical basis for the clinical diagnosis and treatment of patients. Methods: Ninety-to cases of hypertensive patients with phlegm-dampness constitution during pregnancy admitted to our hospital from January 2018 to May 2019 were selected.The random number table method was used to divide into the conventional group (n=46) and the combined group (n=46).The patients in the routine group were treated with Traditional Chinese medicine combined with appropriate exercise and auxiliary drugs, and the combined group was treated with auricular point sticking on the basis of the conventional group.The quality of life, blood pressure, blood lipid level, and phlegm-dampness constitution of the two groups were compared before and after treatment. Results: After treatment, the emotional role, mental health, physical function, and mental health scores of patients in the combined group were [(80.97±5.10) points, (78.31±6.37) points, (76.25±7.57) points, and (73.48±6.23) points] , which were significantly higher than the conventional group [(74.55±5.09) points, (70.92±6.34) points, (65.38±7.52) points, and (65.79±6.22) points], and the difference was statistically significant (P<0.05); the systolic blood pressure, diastolic blood pressure, triglyceride and total cholesterol levels of patients in the combination group were [(101.40±6.80)mmHg, (60.90±7.42)mmHg, (1.75±0.22)mmol/L, and (5.01±0.26)mmol/ L], which were all significantly lower than[(108.20±7.70)mmHg, (67.65±7.43)mmHg, (2.01±0.23)mmol/L, and (5.39±0.27)mmol/L] in the conventional group and the difference was statistically significant (P<0.05); the sputum physique scores after 1 week of treatment in the combined group were [(20.05±3.77) points, (16.76±3.61) points, and (9.52±3.11) points], which were significantly lower than[(24.92±3.78) points, (19.80 ±3.62) points, and (13.86±3.12) points]in the conventional group, and the difference was statistically significant (P<0.05). Conclusion: Auricular point sticking combined with traditional Chinese medicine food therapy can effectively improve the quality of life of hypertensive patients with phlegm-dampness constitution during pregnancy, reduce their blood pressure and blood lipid levels, and improve their phlegm-dampness symptoms, which is worthy of clinical promotion.
    Analysis of factors such as dental caries and feeding methods of 3-year-old children in eastern Anhui
    Zhang Ruixiu, Zhang Zhengfu
    2021, 42(6):  427-429.  DOI: 10.3969/j.issn.2097-0005.2021.06.007
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    Objective: To study the factors such as dental caries and feeding methods of 3-year-old children in Eastern Anhui. Methods: 1188 3-year-old children from September 2019 to June 2020 in eastern Anhui Province were selected.The subjects of the study were 1188 3-year-old children in eastern Anhui.Retrospective analysis of the family information and feeding methods of 3-year-old children, and statistical analysis on related data were made. Results: The incidence of dental caries in young children was significantly different in the three factors of infant feeding methods, family income, and daily caregivers, and the data differences were statistically significant (P<0.05). Conclusion: It is necessary to strengthen the education of health knowledge about dental caries prevention for parents and children themselves to reduce the incidence of dental caries in children, ensure the normal growth and development of children.
    Analyze the correlation between postpartum depression and personality characteristics of senile parturients
    Wang Ting, Lv Ke, Zhou Fangfang
    2021, 42(6):  430-432.  DOI: 10.3969/j.issn.2097-0005.2021.06.008
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    Objective: To study the correlation between postpartum depression and personality characteristics of elderly parturients. Methods: Enrolled 273 elderly parturients who were admitted to the obstetrics department of Chuzhou People's Hospital, which has established a green channel for treatment with our school, from January to December 2018. They were older than 35 years old, with an average age range of (37.1±1.1)years and a gestational age of 37~ 42 weeks.This study was conducted by questionnaire survey, using the Eysenck Personality Questionnaire (EPQ-RSC), "susceptibility personality characteristics scale, VPSQ" and "Edinburgh Postpartum Depression Scale, EPDS" questionnaire survey. Results: The Edinburgh Postpartum Depression Scale showed that there were 45 parturients with EPDS≥13, with an average score of (16.03±2.83),and the incidence of postpartum depression was 16.48%.Compared with the non-depressed group, the introversion score in the depressed group was significantly decreased, while the neuroticism score was significantly increased (P<0.05).The susceptibility personality characteristics scale score, the score value of the susceptibility subscale of depressed mothers is (22.14±2.83),which is extremely significantly higher than the score value of (11.24±1.47)of the susceptibility subscale of non-depressed patients(P<0.001).The total r value of EPDS score and VPSQ score is 0.72,which indicates that the susceptible personality characteristics of elderly parturients are positively correlated with postpartum depression. Conclusion: The susceptible personality characteristics of elder parturients are positively correlated with postpartum depression.Therefore,the susceptible personality characteristics of elder parturients can be scored before childbirth to predict the occurrence of postpartum depression early and carry out early intervention to effectively prevent postpartum depression.
    The effect of memantine hydrochloride in treating patients with Parkinson's disease on improving their cognitive function and ability of daily living
    Wang Zhiqiang, Hu Yakun, Li Yanhua
    2021, 42(6):  433-435.  DOI: 10.3969/j.issn.2097-0005.2021.06.009
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    Objective: To treat PDD patients with memantine hydrochloride and observe its therapeutic effect. Methods: A total of 93 PDD patients treated in our hospital were selected and the cases from August 2018 to July 2020 were included, and they were divided into two groups.46 cases in the control group received conventional treatment (dopaserzide tablets + donepezil hydrochloride tablets);47 cases in the observation group were treated with memantine hydrochloride in combination on the conventional basis. The cognitive function (MoCA scale, MMSE scale), ability of daily living (ADL scale), and adverse reactions of the two groups were compared. Results: After treatment, the MoCA score,MMSE score and ADL score of the observation group were significantly higher than those of the control group (P<0.05); the adverse reaction rates of the observation group and control group were 13.04% and 17.02%, respectively, with no significant difference(P>0.05). Conclusion: On the basis of conventional treatment, the application of memantine hydrochloride treatment to PDD patients can better improve the cognitive function of patients, improve their living ability, and will not increase adverse reactions.
    Effect of modified Sijunzi Decoction combined with triple drug on HP related gastroduodenal ulcer
    Li Zhipeng, Li Weiming
    2021, 42(6):  436-438.  DOI: 10.3969/j.issn.2097-0005.2021.06.010
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    Objective: To investigate the clinical efficacy of modified Sijunzi Decoction combined with triple drug in the treatment of Helicobacter pylori (HP) positive gastroduodenal ulcer. Methods: Eighty-six patients with HP related gastroduodenal ulcer were randomly divided into the observation group and the control group. Forty-three patients in the control group were treated with conventional triple drug therapy, while the observation group were treated with modified Sijunzi Decoction on the basis of triple drug therapy. Results: The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05); Before treatment, there was no significant difference in the levels of serum IL-8, IL-10 and EGF in gastric juice between the two groups (P>0.05).After treatment,the levels of IL-8 and IL-10 in the observation group were significantly lower than those in the control group, while the level of EGF in gastric juice was significantly higher than that in the control group (P<0.05); The HP eradication rate of the observation group was significantly higher than that of the control group, and the follow-up results within one year after treatment showed that the recurrence rate of gastroduodenal ulcer of the observation group was significantly lower than that of the control group (P<0.05). Conclusion: Modified Sijunzi Decoction on the basis of conventional triple drugs in the treatment of HP related gastroduodenal ulcer can effectively improve the treatment efficiency, improve the serum inflammatory state of patients, and has a positive effect on improving the eradication rate of HP and reducing the recurrence rate of ulcer after treatment.
    The value of serum and cerebrospinal fluid S-100β,NSE,MBP combined with slCAM-1 in evaluating the neurological function of children with viral encephalitis
    Liu Baoru, Zhou Jiangchao
    2021, 42(6):  439-441.  DOI: 10.3969/j.issn.2097-0005.2021.06.011
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    Objective: To explore the value of serum and cerebrospinal fluid S-100β, NSE, MBP combined with slCAM-1 in evaluating the neurological function of children with viral encephalitis. Methods: A total of 130 children with viral encephalitis who were admitted to the Department of Neurology in our hospital from June 2018 to December 2019 were selected. According to the clinical manifestations, they were divided into the barrier-free group (without central nervous function barrier, 68 cases) and the barrier group (with central nervous system dysfunction, 62 cases). The evaluation of the values of S-100β, NSE, MBP, slCAM-1 levels in the children with neurological function in each group was made. Results: The levels of S-100β, NSE, MBP and slCAM-1 in serum and cerebrospinal fluid of the barrier group were higher than those of the barrier group (P<0.05). The sensitivity and specificity of the four combined tests were higher than those of the individual tests(P<0.05). Conclusion: Serum and cerebrospinal fluid S-100β, NSE, MBP combined with slCAM-1 are closely related to the neurological function of children with viral encephalitis.The detection of the levels of four items in serum and cerebrospinal fluid is helpful for the assessment of the neurological function of children.
    Effect of combined anesthesia of remifentanil and sevoflurane in elderly patients undergoing laparoscopic surgery
    He Youli, Kong Jing
    2021, 42(6):  442-444.  DOI: 10.3969/j.issn.2097-0005.2021.06.012
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    Objective: To observe the effect of combined anesthesia of remifentanil and sevoflurane in elderly patients undergoing laparoscopic surgery. Methods: A total of 90 elderly patients undergoing laparoscopic surgery in our hospital from January 2019 to June 2020 were selected and divided into control group (n=45) and observation group (n=45) according to random number table method.The control group was anesthetised with remifentanil, and the observation group was anesthetised with combined sevoflurane and remifentanil.SOMCT score, Steward resuscitation score, extubation, resuscitation time and adverse reactions were compared between the two groups at each time point. Results: The comparison of SOMCT scores at 1h and 3h after extubation between the two groups showed that the observation group was better than the control group (P<0.05), which was statistically significant.Comparison of Steward recovery scores at extubation and 15min extubation between the two groups showed that the observation group was better than the control group (P<0.05), which was statistically significant.The comparison of extubation and recovery time between the two groups showed that the observation group was better than the control group (P<0.05), which had statistical value. Comparison of adverse reaction rate between the two groups showed that observation group was better than control group (P<0.05), which was statistically significant. Conclusion: Combined anesthesia of sevoflurane and Remifentanil has a significant effect on postoperative short-term cognitive function in elderly patients undergoing laparoscopic surgery.In other words, it has little influence on postoperative short-term cognitive function, can improve the quality of recovery, and promote postoperative recovery of patients with fewer adverse reactions. Therefore, it is worth promoting research.
    Clinical effect of anesthesia induction combined with dexmedetomidine in thoracolumbar fracture surgery
    Sun Suhua
    2021, 42(6):  445-447.  DOI: 10.3969/j.issn.2097-0005.2021.06.013
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    Objective: To study and analyze the clinical effect of anesthesia induction combined with dexmedetomidine in thoracolumbar fracture surgery, focusing on the effect on hemodynamics and recovery process of patients during periextubation. Methods: 106 cases of thoracolumbar fracture surgery patients received by the department of orthopedics in our hospital from June 2019 to June 2020 were randomly divided into routine group (normal saline) and study group (dextromethorhomidine), 53 cases each.In the study group, Dexmedetomidine was added on the basis of general anesthesia to observe the time of recovery, extubation time, blood pressure, heart rate changes, etc. Results: When the blood pressure at T2 was higher than T0, the heart rate was lower than T0 (P<0.05), but there was no difference in blood pressure and heart rate between the two groups (P>0.05).The study group had a significantly lower score for restlessness and longer wake time and extubation time than the control group (P<0.05).The dosage of dextrometomidine was not correlated with heart rate and blood pressure, but positively correlated with extubation time and wake time, and negatively correlated with agitation score. Conclusion: For thoracolumbar fracture patients under general anesthesia, dextromethorax can help patients stabilize their blood pressure and heart rate during peritubal extubation and improve their resuscitation process. It has a good effect and is worthy of clinical attention and wide application.
    Clinical effects of minimally invasive thoracoscopic surgery and traditional surgery on primary mediastinal tumors
    Bi Siyun
    2021, 42(6):  448-450.  DOI: 10.3969/j.issn.2097-0005.2021.06.014
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    Objective: To investigate the clinical effect of traditional surgery and minimally invasive surgery via thoracoscopy (VATS) for primary mediastinal tumor. Methods: A total of 94 patients with primary mediastinal tumor admitted to Juye People's Hospital from February 2018 to June 2019 were selected as the study objects. They were randomly divided into two groups according to the digital randomization method, among which the control group was given traditional surgical treatment, while the observation group was treated with minimally invasive surgery via thoracoscopy to compare the therapeutic effects of the two groups. Results: The duration of hospitalization, drainage, analgesic use and operation was shorter in the observation group than those in the control group (P<0.05) and intraoperative blood loss was less than that of the control group (P<0.05); Compared with the control group, the incidence of postoperative complications in the observation group was low, and the differences between the groups were significant (P<0.05); At the same time, the postoperative serum inflammatory factor levels of the two groups were statistically significant (P<0.05). Conclusion: The application of minimally invasive surgery via thoracoscopy in the treatment of patients with primary mediastinal tumor can not only reduce the body's inflammatory response, but also reduce postoperative complications and shorten the length of hospital stay.
    Clinical effect of endoscopic sinus surgery combined with drugs in the treatment of chronic sinusitis with nasal polyps
    Cao Hui, Liu Yong, Zheng Chengcai
    2021, 42(6):  451-453.  DOI: 10.3969/j.issn.2097-0005.2021.06.015
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    Objective: To explore the clinical effect of endoscopic sinus surgery combined with drugs in the treatment of chronic sinusitis with nasal polyps. Methods: From March 2019 to March 2020, 63 patients with chronic sinusitis and nasal polyps in our hospital were selected as the research objects. According to the random number table method, the patients were randomly divided into control group (31 cases) and observation group (32 cases), in which the control group was treated with surgery alone, and the observation group was treated with surgery combined with drugs. The olfactory function of patients was analyzed and The complications and the total effective rate of treatment were compared between the two treatment modes. Results: The score of olfactory function in the observation group was lower than that in the control group (P<0.05). The incidence of postoperative complications in the observation group was lower than that in the control group (P<0.05). The total effective rate of the observation group was higher than that of the control group (P<0.05). Conclusion: The curative effect of endoscopic sinus surgery combined with drugs in the treatment of chronic sinusitis with nasal polyps is better than that of surgery alone. At the same time, the olfactory function of the combined treatment is more ideal, and the risk of complications is less.
    Relationship to prognosis in changes of serum Ghrelin and NDAL levels in patients with acute pancreatitis
    Dai Wenling
    2021, 42(6):  454-456.  DOI: 10.3969/j.issn.2097-0005.2021.06.016
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    Objective: To investigate the relationship between the levels of Ghrelin and neutrophil gelatinase-associated lipid lipocalin (NGAL) in peripheral blood and the prognosis of patients with acute pancreatitis (AP). Methods: To analyze the data of 75 acute pancreatitis patients admitted to Ningyang County First People's Hospital from October 2019 to September 2020, including 41 cases of acute mild pancreatitis(MAP group)and 34 cases of acute severe pancreatitis(SAP group).2ml venous blood was collected immediately after admission in the whole group, and the serum was separated by centrifugation, and stored in ultra-low temperature for backup test. The differences of serum Ghrelin and NGAL levels on the first day after admission were compared between the two groups. Results: The serum Ghrelin and NGAL levels of patients in the acute severe pancreatitis group were significantly higher than those in the acute mild pancreatitis group, with statistically significant differences (P<0.001). Conclusion: The early serum levels of Ghrelin and NGAL in patients with acute pancreatitis are closely related to the severity of the disease, and the increased serum levels of Ghrelin and NGAL suggest a poor prognosis and deserve clinicians' attention.
    Clinical efficacy of tirofiban hydrochloride in the treatment of progressive stroke and transient ischemic attack
    Ma Fujing
    2021, 42(6):  457-459.  DOI: 10.3969/j.issn.2097-0005.2021.06.017
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    Objective: To investigate the value of tirofiban hydrochloride in the treatment of progressive stroke and transient ischemic attack. Methods: 100 patients with Progressive stroke and transient ischemic attack from the Department of Neurology in June 2017 to June 2019 were analyzed, randomized digital table method was used to divide the observation group (control group, n=50) and hydrochloric acid treatment group (observation group,n=50) coagulant function index, nerve function score, the rate of adverse drug reactions, recurrent stroke were detected for comparison. Results: Before the treatment, there was no statistically significant difference between the two groups in coagulation function indexes APTT, PLT, PT and pecam-1 (P<0.05), no significant changes were observed in the APTT, PLT and PT indexes after the treatment (P>0.05); However, the pecam-1 index was significantly higher than that before treatment, and the observation group was significantly higher than that of the control group, with statistically significant differences (P<0.05).There was no difference in neurological function scores between the two groups before treatment (P>0.05). After treatment, the scores were all reduced, and there was a more significant reduction in the observation group, with statistically significant differences (P<0.05). Conclusion: Tirofebanja hydrochloride on the basis of conventional treatment can improve platelet aggregation, promote the recovery of nerve function, and reduce the risk of stroke recurrence without serious adverse reactions for progressive stroke and transient ischemic attack.
    Clinical value of minimally invasive ankle arthrodesis in the treatment of traumatic ankle arthritis
    Xu Dong
    2021, 42(6):  460-462.  DOI: 10.3969/j.issn.2097-0005.2021.06.018
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    Objective: To investigate the clinical value of arthroscope-assisted ankle arthrodesis in the treatment of traumatic arthritis of foot and ankle. Methods: From February 2017 to May 2019, retrospective analysis of the 43 cases of the clinical data of patients with severe traumatic ankle arthritis was made, 23 cases of ankle arthrodesis was performed arthroscopically (minimally invasive group), 20 patients who underwent open ankle arthrodesis (open group), and postoperative pain score difference of the day and 7 days, and osseous fusion rate after 6 months and 1 year and the differences between the AOFAS ankle function score were compared two groups of patients. Results: The pain scores of the minimally invasive group were (4.18±1.10) and (1.55±0.52) 1 and 7 days after surgery, which were both lower than those of the open group(5.54±1.15)and(3.45±0.58).The differences were statistically significant (t=-3.959,-11.327,P<0.001). The bone fusion rate of the minimally invasive group was 82.61% 6 months after surgery, which was significantly higher than that of the open group(35.00%).The difference was statistically significant (χ2=10.143, P<0.001). Bone fusion was formed in both groups at 1 year after surgery. Six months after surgery, there was no difference in AOFAS ankle function score between the two groups (P>0.05).AOFAS score was (77.55±5.70) in the minimally invasive group and (66.49±4.55) in the open group 1 year after surgery, and the difference between the two groups was statistically significant(t=6.977, P<0.001). Conclusion: Minimally invasive ankle arthrodesis has more advantages in the treatment of severe traumatic arthritis of foot and ankle, which can reduce postoperative pain, improve the rate of early bone fusion and accelerate the recovery of foot and ankle function, which is worthy of further basic and clinical studies.
    Comparison of the clinical value of routine blood test between venous blood and peripheral blood
    Tian Nannan
    2021, 42(6):  463-465.  DOI: 10.3969/j.issn.2097-0005.2021.06.019
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    Objective: To compare the routine blood tests of venous blood and peripheral blood and analyze their clinical application value. Methods: Eighty patients with routine blood test collected in our hospital from February 2020 to October 2020 were selected and divided into two groups, control group and observation group, with 40 patients in each group. In the control group, peripheral blood was collected for routine blood test, while in the observation group, venous blood was collected for routine blood test, and the routine blood test of patients in the two groups was observed and compared. Results: The WBC in the observation group was significantly higher than that in the control group, and the difference was statistically significant.Compared with the control group, platelet (PLT), mean red blood cell hemoglobin content (MCHC), mean red blood cell volume (MCV), hemoglobin (Hb), red blood cell (RBC), specific volume of red blood cell (HCT) and other related indicators were all higher than the control group (P<0.05). However, there was no statistically significant difference in MCH between the two groups(P>0.05).Blood routine test results showed that there was no statistical significance in RBC, WBC, MXD, PLT and other indicators detected within 3 h after venous blood collection compared with immediate test (P>0.05). There was no statistically significant difference in RBC and WBC (P>0.05),but MXD was significantly increased and PLT was significantly decreased (P<0.05). Conclusion: In routine blood test, the effect of venous blood test is more stable, but the time of sending blood test should be strictly controlled.
    Diagnosis and treatment of 21 cases with post necrotizing enterocolitis strictures in infants
    Liu Wei
    2021, 42(6):  466-468.  DOI: 10.3969/j.issn.2097-0005.2021.06.020
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    Objective: To investigate the diagnosis and treatment of neonatal necrotizing enterocolitis (NEC) posterior bowel stricture. Methods: Data of 21 patients with NEC posterior bowel stenosis admitted to our hospital from February 2015 to September 2020 were retrospectively analyzed, and the growth and development of the children were followed up.In accordance with the Bell stage, 5 cases in periodⅠ, 14 cases in periodⅡ and 2 cases in period Ⅲ among the 21 cases. All the children were preoperatively examined by orthographic abdominal X-ray, and 19 cases were simultaneously examined by high-frequency ultrasound.All the 21 cases received surgical treatment after diagnosis. Results: The average consultation time for NEC's posterior intestinal stricture was 29.5 days.Abdominal elevations showed inflating intestinal curvature, and 20 cases presented stepped liquid and gas plane.High-frequency ultrasound examination showed extensive dilatation and effusion of the intestine.Most of the stenosis sites were found in ascending colon, transverse colon and descending colon.Twenty-one cases had intestinal anastomosis Ⅰ period bowel resection, were cured after operation and discharged, and had no deaths.Among 18 cases followed up for a long time, 17 cases had normal diet and development, and 1 case was cured and discharged after intestinal adhesion release due to adhesion obstruction. Conclusion: Colon is more common in NEC posterior bowel stricture.Preoperative abdominal X-ray and high frequency ultrasound are the first methods.It is advisable to narrow bowel resection in the treatment for intestinal anastomosis in periodⅠ.