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25 April 2021, Volume 42 Issue 4

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Analysis on health literacy and its influencing factors about cancer prevention and control among urban cancer patients in Anhui

CHEN An-an, JIANG Jian-jian, WANG De-bin, SHEN Xing-rong, WEI Dong-hua, CHAI Jing

2021, 42(4):  241-245.  DOI: 10.3969/j.issn.1004-7115.2021.04.001

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Objective: To investigate health literacy and its influencing factors about the cancer prevention and control among urban cancer patients in Anhui. Methods: Cluster random sampling was used to select 519 cancer patients in Hefei, Anhui Province.The cancer prevention and health literacy questionnaire provided by the National Urban Cancer Early Diagnosis and Treatment Project was used as the questionnaire to conduct face-to-face surveys.Results: 68.7% of cancer patients had health literacy for cancer prevention and control.Among them, 69.9%, 72.9%, and 45.7% had awareness of prevention, early detection, early diagnosis and early treatment, and awareness of the need for cancer prevention knowledge;Multivariate logistic regression analysis showed that the independent influencing factors of health literacy of cancer prevention and treatment in cancer patients were age and occupation(P<0.05).Conclusion: Cancer prevention and treatment workers should comprehensively consider the population's age and occupational factors, take prevention and treatment methods and the incentives for cancer as the key publicity content, and adopt targeted publicity methods to improve the health literacy level of cancer prevention and control of cancer patients .

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Determination of oil utilization ratio of peppermint oil-β-cyclodextrin inclusion compound by selective solvent extraction-polarimetry method

CHEN Kai-yue, YAN Fu-peng, WANG Jia-wen, SHAO Xin-yi, LI Fei

2021, 42(4):  246-248.  DOI: 10.3969/j.issn.1004-7115.2021.04.002

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Objective: To establish a selective solvent extraction-polarimetry method for determination of oil utilization ratio of peppermint oil-β-cyclodextrin inclusion compound.Methods: Peppermint oil in the compound was extracted using absolute alcohol as the selective solvent and was determined by polarimetry method. The results of both selective solvent extraction-polarimetry and steam distillation method were compared.Results: The utilization ratio of oil was successfully determined by selective solvent extraction - polarimetry method, the linear range was 20~640 mg﹒ml^-1(r=0.9997), and the recovery was higher than 95% (RSD<2%).Conclusion: Selective solvent extraction-polarimetry method is rapid and accurate, and can be used to determine the oil utilization ratio of peppermint oil-β-cyclodextrin inclusion compound.

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Suppression of Survivin and VEGF antisense oligonucleotide on growth in tongue squamous cancer cells

YU Xiao-peng, LI Xiao-guang, WAN Guang-yong, LI Teng-yu , WANG Yan-xiu , GAO Jing , YAO Yao

2021, 42(4):  249-253.  DOI: 10.3969/j.issn.1004-7115.2021.04.003

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Objective: To observe the effects of Survivin and vascular endothelial growth factor antisense oligonucleotide (Survivin-ASODN and VEGF-ASODN) on growth in tongue cancer cells.Methods: The Survivin-ASODN and VEGF-ASODN was synthesized artificially with phosphorothioic acid.Survivin-ASODN and VEGF-ASODN were transfecting in tongue cancer cells Tca8113.The quantity of Survivin and VEGF protein was detected by immunohistochemistry.FCM and MTT method were used to detect cellular apoptosis and the activity of cells, respectively.The effect of transfection on the growth of cells was evaluated by Growth curve.SPSS22.0 statistical software was used for statistical analysis.Results: The protein levels of Survivin and VEGF in the cells decreased when Survivin -ASODN and VEGF-ASODN were transfected (P<0.01).The ratio of apoptosis increased, and the activity of cells also decreased as transfected Survivin-ASODN and VEGF-ASODN (P<0.01).Conclusion: Transfection with Survivin-ASODN and VEGF-ASODN in tongue cancer cells Tca8113 can inhibit the expressions of Survivin and VEGF remarkably, which can enhance cellular apoptosis and suppress growth of cells.

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Role of TRPV4-P38α pathway in dorsal root ganglion induced neuropathic pain

ZHANG Xiao, YAN Ping-ping, ZHANG Li-juan, YIN Tao, GAO Qiang, ZHENG Zun-cheng

2021, 42(4):  254-257.  DOI: 10.3969/j.issn.1004-7115.2021.04.004

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Objective: To investigate the role of transient receptor potential vanilloid 4 (TRPV4) and P38α in neuropathic pain induced by chronic compression of dorsal root ganglion (CCD) in rats.Methods: Healthy adult male Wistar rats were randomly divided into blank group, CCD group and CCD+ruthenium red group. Paw withdrawal mechaical threshold (PWMT) was measured 1 day before surgery, 1 day, 7 days, and 21 days after surgery in the blank group and CCD surgery group. The CCD+ruthenium red group were injected with ruthenium red on the 7th day after surgery, and the PWMT was measured before and after that; RT-PCR was used to detect the expressions of TRPV4 and P38α genes in the dorsal root ganglion (DRG) in each group of the rats.Results: Compared with the blank group, the PWMT of the CCD group decreased significantly on the operation side (P<0.001), and the CCD 7-day group had the most significant decrease (P<0.001). The expressions of TRPV4 and P38α genes in the ipsilateral DRG were significantly increased (P<0.001), and the CCD 7-day group had the most significant increase (P<0.001). After 2 hours of ruthenium red injection, the PWMT of the CCD group significantly increased (P<0.001), while the P38α gene expression in the ipsilateral DRG was significantly reduced (P<0.001).Conclusion: The expressions of TRPV4 and P38α genes in the DRG of the operative rats after CCD are consistent with the changes of PWMT. The TRPV4-P38α signal pathway may be involved in the pathological process of neuropathic pain caused by CCD.

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Application of psychological intervention based on the concept of acceptance and commitment therapy in caregivers of pediatric burns

SHI Xin-yu, LI Xue-xue, SUN Zheng, ZHAO Yun-xia

2021, 42(4):  258-260.  DOI: 10.3969/j.issn.1004-7115.2021.04.005

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Objective: To explore the effect of psychological intervention based on the concept of acceptance and commitment therapy in caregivers of burn patients with the view to providing theoretical guidance and practical basis for clinical application of this program.Methods: Using convenience sampling method, 110 caregivers of burn patients in Burn Department of the Second Affiliated Hospital of Shandong First Medical University were randomly divided into control group and test group.The routine health education was carried out in the control group; the experimental group was supplemented by psychological intervention based on admission commitment therapy on the basis of routine care. The general information questionnaire, Self Ratinganxiety Scale(SAS),Connor-Davidson Resilience Scale (CD-RISC) and Herth Hope Index scale (HHI) were used.The scores of the two groups of subjects at T1and T2 were investigated.Results: Before the intervention, there was no significant difference in the scores of SAS, CD-RISC and HHI between the two groups (P﹥0.05). After the intervention, the SAS score of the patients in the experimental group was lower than that of the control group, and the scores of CD-RISC and HHI were higher than those of the control group (P<0.05).Conclusion: Psychological intervention based on the concept of acceptance and commitment therapy can effectively improve the acceptance of psychological crisis in caregivers of pediatric burn patients, improve negative emotions such as guilt,anxiety, depression,and increase the level of mental resilience and hope.

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Determination of caffeine in tea from Anhui Province by HPLC

WANG Chuan-ying, ZHU Zhi-hua, JI Ting-ting, XU Yu-fang

2021, 42(4):  261-263.  DOI: 10.3969/j.issn.1004-7115.2021.04.006

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Objective: To compare the content of caffeine in five batches of tea from different areas of Anhui Province.Methods: HPLC was used.Mobile phase: methanol and water was (40∶60), flow rate 1 ml per minute, and detection wavelength was 271 nm.Results: The content of caffeine in tea of Anhui Province was less than 5%.Conclusion: The method is simple, convenient, accurate and reproducible.It can be used for the determination of caffeine in tea.This experiment provides a reference for further study on the quality of Anhui tea and further processing with tea as raw material

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A clinical study on the effect of Lichtenstein repair versus mesh plug repair in the treatment of adult inguinal hernia

CHEN Jun-hao, WEI Guo-huai, HUANG Jun-yi

2021, 42(4):  264-266.  DOI: 10.3969/j.issn.1004-7115.2021.04.007

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Objective: To compare the clinical effect and complications of Lichtenstein repair versus mesh plug repair in the treatment of inguinal hernia.Methods: 120 adult patients with indirect inguinal hernia admitted to Jianghai branch of Jiangmen Central Hospital from January 2015 to January 2019 were selected as the research objects, 60 cases were treated by Lichtenstein repair as experimental group, and the other 60 cases were treated by mesh plug repair as control group.The operation time, length of hospital stay, and complications were compared. The recurrence was recorded with 12 months follow up.Results: The operation time of mesh plug group was significantly longer(45.5±4.10 VS 35.5±3.50,P<0.05) and the cost was lower in Lichtenstein group.The incidence of postoperative neuralgia in the Lichtenstein group was statistically significant (P<0.01).In mesh plug group, 58 cases were cured, 2 cases recurrence, and the total effective rate was 96.67% (58/60); in the Lichtenstein group, 59 cases were cured, 1 case had recurrence, and the total effective rate was 98.33% (59/60).There was no significant difference in the total effective rate between the two groups (P>0.05) . Conclusion: The therapeutic effect of the two methods is similar, but the Lichtenstein method is much more simple to operate, and the postoperative nerve pain is lower, which is worthy promoting.

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Analysis of serum lipid level in patients with non-small cell lung cancer

YUAN Xu-long, ZHAO Man, JI Bo, MU Yu-shu

2021, 42(4):  267-269.  DOI: 10.3969/j.issn.1004-7115.2021.04.008

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Objective: To analyze the cholesterol (CHOL), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein A (ApoA), apolipoprotein B (ApoB), and free fatty acid (FFA) in patients of non-small cell lung cancer and normal people.The relationship between non-small cell lung cancer and serum lipids was explored as well. Methods: BECKMAN COULTER AU5800 automatic biochemical analyzer was used to determine the serum lipid levels of 267 patients with non-small cell lung cancer and 260 normal people. SPSS 18.0 was used to statistically analyze the data of two groups. Results: Analysis of the non-small cell lung cancer patient group and the control group showed that CHOL, TG, HDL, LDL, ApoA were not statistically different between the two groups (P>0.05).The levels of ApoB and FFA in the non-small cell lung cancer patient group were higher than those in the control group.The difference was statistically significant (P<0.05). Conclusion: The detection of serum lipids, ApoB and FFA are significantly increased in the non-small cell lung cancer patient group, suggesting that Apo B and FFA play a certain role in the development of non-small cell lung cancer.

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Differential diagnosis analysis of low-dose MSCT scanning for benign and malignant solitary pulmonary nodules

ZHAI Zhi-jian, SHANG Wei, LI Wen-qing, LIU Wen-jun

2021, 42(4):  270-272.  DOI: 10.3969/j.issn.1004-7115.2021.04.009

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Objective: To investigate the value of low-dose multi-slice spiral CT (MSCT) in the differential diagnosis of benign and malignant solitary pulmonary nodules (SPN).Methods: 68 patients with SPN who were treated in Anyang People's Hospital from November 2018 to November 2020 were selected as the research objects.All patients received MSCT to confirm the benign and malignant nodules, and MSCT low-dose scans in the diagnostic value of SPN benign and malignant differentiation were analyzed with surgical pathology as the "gold standard".Results: With the use of the pathological results as the "gold standard", the accuracy of MSCT scanning in the differentiation of SPN benign and malignant was 92.65%, the sensitivity was 93.18%, and the specificity was 91.67%, which was in good agreement with the pathological results (Kappa=0.841). The typical imaging features of malignant nodules were irregular or lobed edges, blurring, and uniform internal structure; benign nodules had clear edges and most of them were accompanied by calcification. The imaging features of the two groups were compared, and the difference was statistically significant (P <0.05). Conclusion: The low-dose MSCT scan is of high value in the differential diagnosis of benign and malignant SPN. It can be effectively differentiated by the imaging features of the edges and internal structure of the two, and has high clinical application value.

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Investigation into the effects of nifedipine combined with magnesium sulfate on uterine arterial hemodynamics perinatal outcome and blood viscosity in patients with gestational hypertension

WANG Ting, LIU Yan

2021, 42(4):  273-276.  DOI: 10.3969/j.issn.1004-7115.2021.04.010

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Objective: To investigate the effect of nifedipine combined with magnesium sulfate in the treatment of pregnancy hypertension, and to observe the effect of nifedipine combined with magnesium sulfate on uterine arterial hemodynamics, perinatal outcome and blood viscosity.Methods: A total of 100 patients with gestational hypertension admitted to Yuncheng County People's Hospital from July 2017 to July 2020 were selected and divided into single treatment group and combined treatment group according to random number table method, with 50 cases in each group.The patients in the single treatment group were treated with magnesium sulfate, and the patients in the combined treatment group were treated with nifedipine on the basis of the control group.The clinical treatment effect, uterine arterial hemodynamics, blood viscosity and perinatal outcome of the two groups were compared.Results: The effective rate of combined treatment group was as high as 96.00% (48/50), which was significantly higher than that of single treatment group 82.00% (41/50), and the difference was statistically significant(χ²=5.005,P<0.05).After treatment,the DBP,SBP,24h urinary protein and blood viscosity in the combined treatment group were significantly lower than those in the single treatment group (P<0.05).The levels of RI, PI and S/D in combined treatment group were significantly lower than those in single treatment group (P<0.05).The incidence of adverse perinatal outcomes was 6.00% (3/50) in the combined treatment group and 22.00% (11/50) in the single treatment group, and the former was significantly lower than the latter (P<0.05).The incidence of adverse perinatal outcomes in perinatal infants was 14.00%(7/50) in the combined treatment group and 34.00% (17/50) in the single treatment group, and the former was significantly lower than the latter (P<0.05).Conclusion: Compared with magnesium sulfate alone, nifedipine combined with magnesium sulfate can effectively control blood pressure, reduce blood viscosity, improve uterine arterial hemodynamics and perinatal outcome in patients with gestational hypertension, which is worthy of clinical promotion.

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Clinical effect of low temperature plasma on tonsil adenoid hypertrophy in children

JIA Yuan-yuan

2021, 42(4):  277-278.  DOI: 10.3969/j.issn.1004-7115.2021.04.011

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Objective: To study the clinical effect of low temperature plasma on tonsil adenoid hypertrophy in children.Methods: The medical small sample was compared in the analysis. A total of 86 children with adenoid hypertrophy of the tonsils in Kaifeng Children's Hospital were selected and divided into two group, control group and experimental group respectively according to the differences between treatment and control of proportion, with the former given medication, the latter with joint low temperature plasma treatment, and the clinical efficacy of the two groups was compared. Results: The comparison results of clinical efficacy between the experimental group and the control group were 95.35% and 79.07% respectively (P<0.05).The comparison of visual analogue scale (VAS) score and OSA-18 scale values between the experimental group and the control group were (1.12±0.23),(3.94±0.84) (6.51±1.38) and (3.47±1.13), respectively.Conclusion: Low temperature plasma treatment of adenoid hypertrophy of tonsil in children can significantly improve the prognosis of children and is worthy of clinical promotion and implementation.

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Clinical effect of bronchoscopic foreign body removal combined with bronchoalveolar lavage in the treatment of plant-derived bronchial foreign body in children

REN Rui-juan

2021, 42(4):  279-280.  DOI: 10.3969/j.issn.1004-7115.2021.04.012

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Objective: To investigate the therapeutic effect of bronchoscopic foreign body removal combined with bronchoalveolar lavage in children with plant bronchial foreign body.Methods: A total of 70 children with plant-derived bronchial foreign body in our hospital were selected, and the children were divided into groups by the numerical random table method, with 35 patients in each group.The patients in the control group were treated with bronchoscopic foreign body removal, while the patients in the observation group were treated with bronchoalveolar lavage on this basis of bronchoscopic foreign body removal, and the results of the two groups and the disappearance time of various complications were compared.Results: The effective rate of the observation group was higher than that of the control group, but the difference was not statistically significant .The improvement of cough, wheezing, shortness of breath and wet rales in the observation group was better than that in the control group, and the difference was statistically significant.Conclusion: Bronchoscopic foreign body removal combined with bronchoalveolar lavage in the treatment of children with plant bronchial foreign body has a relatively good effect, which can shorten the length of hospital stay and the disappearance of symptoms and signs.

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Study on the changes and clinical significance of T cells and NK cells in peripheral blood of patients with primary hepatocellular carcinoma

ZHANG Xian-li

2021, 42(4):  281-283.  DOI: 10.3969/j.issn.1004-7115.2021.04.013

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Objective: To investigate the changes of T cells and NK cells in peripheral blood of patients with primary hepatocellular carcinoma (HCC) and their relationship with cancer.Methods: T cells and NK cells in peripheral venous blood of 28 patients with primary hepatocellular carcinoma, 29 patients with chronic liver cirrhosis, and 31 healthy adults were analyzed to study their relationship with tumor flight.Results: In the peripheral venous blood of patients with primary liver cancer, the levels of CD3⁺ T cells, CD4⁺ T cells, and NK cells were significantly lower than those of patients with chronic liver cirrhosis and healthy adults, and the difference was statistically significant (P＜0.05); the level of CD8⁺ T cells was significantly higher than that of the patients with chronic liver cirrhosis and healthy adult and the difference was statistically significant (P﹤0.05). In the peripheral venous blood of patients with primary liver cancer, there was no significant difference in the levels of CD3⁺ T cells, CD4⁺ T cells, CD8⁺ T, and NK cells in patients with stage I and II (P>0.05); CD3⁺ T cells, CD4⁺ T in patients with stage III were lower than those of stage I and II patients. The levels of cells and NK cells were significantly lower than those of stage I and II patients, and the levels of CD8⁺ T cells were significantly higher than those of stage I and II patients. The difference was statistically significant (P<0.05).Conclusion: The changes of peripheral venous blood T cell and NK cell levels in patients with primary hepatocellular carcinoma reflect the immune state of the body, and may be closely related to the occurrence of tumor, which is of great clinical significance in judging the condition and prognosis of patients with hepatocellular carcinoma.

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Observation on the preventive effect of dexmedetomidine during cesarean section on chills and traction during spinal anesthesia

DENG Shuang-zhao, WEN Xue-hua, LI Yu-xing, LIANG Xiu-ping, PENG Wei-ping, HUANG Wei-hua

2021, 42(4):  284-286.  DOI: 10.3969/j.issn.1004-7115.2021.04.014

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Objective: To apply dexmedetomidine during intraspinal anesthesia for cesarean section to analyze its effect on preventing chills and traction reactions. Methods: From August 2018 to July 2020, 87 parturients who gave birth by cesarean section in our hospital were all under spinal anesthesia, and they were divided into two groups. In the control group, 43 cases were treated with saline after the fetus was dissected; in the observation group, 44 cases were treated with dexmedetomidine after the fetus was dissected. The prevention effect of chills, the prevention effect of traction reaction and the side effects of the two groups were compared. Results: The incidence of chills in the observation group was 11.36%, and that of the control group was 30.23%, which was a significant difference (P<0.05); the observation group had an excellent rate of 90.91% in prevention of traction response and 74.42% in the control group, which was a significant difference (P<0.05); the maternal adverse reaction rate of the observation group was 6.82%, and that of the control group was 9.30%, there was no significant difference (P>0.05). Conclusion: The application of dexmedetomidine during intraspinal anesthesia for cesarean section can reduce the occurrence of chills, prevent traction reactions, and is safe.

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The relationship between unilateral maxillary labial malposed canines and sagittal facial type in female

XUE Qing , LIU Ying, DING Xiao-hua, JIANG Juan, LI Jun-fu, CHEN Dai-yun

2021, 42(4):  287-288.  DOI: 10.3969/j.issn.1004-7115.2021.04.015

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Objective: To investigate the relationship between unilateral maxillary labial malposed canines and sagittal facial type in female, and evaluate the dentofacial morphological characteristics of female with unilateral maxillary labial malposed canines.Methods: A total of 30 cases of unilateral maxillary labial malposed canines in female patients were selected, and their cephalometric films were measured and analyzed.SPSS17.0 was applied for t test.Results: SNA, A＇-Ptm＇,ANS-Ptm, Wits and L1-NB were smaller than the normal value, U1-NA and U1-NA were greater than the normal value in groups. Conclusion: The unilateral maxillary labial malposed canines of female might result in short maxillary basal bone, and tends to be Class Ⅲ facial type.

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The clinical application of synchronous intermittent mandatory ventilation (volume and pressure-controlled) in patients with acute exacerbation of chronic obstructive pulmonary disease in initial invasive mechanical ventilation

ZHANG Hui, WU Xia, CHEN Xiu-ping, LIU Jia, LEI Lei

2021, 42(4):  289-291.  DOI: 10.3969/j.issn.1004-7115.2021.04.016

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Objective: To investigate the clinical application of (V-SIMV and P-SIMV) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in initial invasive mechanical ventilation.Methods: Eighty-six patients with ACOPD combined with respiratory failure were randomly divided into control group (V-SIMV) and observation group (P-SIMV) in invasive mechanical ventilation with 44 cases and 42 cases respectively .At the initial time,V-SIMV+PSV was used in the control group and P-SIMV+PSV in the observation group.The peak airway pressure (Ppeak), mean airway pressure (Pmean), support pressure (PS), PH value, arterial partial pressure of carbon dioxide (PaCO₂)and effective rate were compared between the two groups 2, 4 and 8 hours after initial invasive mechanical ventilation.Results: ① The Ppeak, Pmean and PaCO₂ in the observation group were significantly lower than those in the control group, and the Vte and pH values were significantly higher than those in the control group (P<0.05).PS was slightly higher than that in the control group, but the difference was not statistically significant (P>0.05).After 8 hours, there was statistical difference between the two groups of Ppeak and Pmean, but there was no significant difference in PS, Vte, pH and PaCO₂.② The chi-square test of two independent samples showed that the effective rate of the observation group (42/42) was 100%; the control group (32/44) 72.7%;12 cases(27.3%) were changed the mode, P≤0.001, and the difference was statistically significant. There were no deaths and discharged patients in the two groups.Conclusion: P-SIMV is more suitable for initial invasive mechanical ventilation in patients with AECOPD,and can improve the effectiveness of initial mechanical ventilation in these patients.

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Observation on the clinical effect of exercise therapy combined with medical ozone and Chinese medicine hot compress on knee osteoarthritis

CAO Jie

2021, 42(4):  292-294.  DOI: 10.3969/j.issn.1004-7115.2021.04.017

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Objective: To investigate the therapeutic effect of exercise therapy combined with medical ozone and Chinese medicine hot compress on knee osteoarthritis.Methods: From March 2017 to May 2018, 80 patients with knee osteoarthritis undergone outpatient and inpatient treatment in Juye County People's Hospital were divided into control group and experimental group, with 40 patients in each group.The control group was treated with medical ozone and hot compress of traditional Chinese medicine, and the experimental group was treated with exercise therapy.The differences between the two groups were analyzed by comparing the functional recovery of knee joint and Lequesne motion score.Results: The results of this experiment indicated that the therapeutic effect of the experimental group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).However, after the completion of this experiment, the condition of both groups improved, and the pain score, morning stiffness and maximum walking distance score of the experimental group were significantly better than that of the control group, with significant differences in data (P<0.05).Conclusion: The exercise therapy combined with medical ozone and Chinese medicine hot compress treatment used for the treatment of knee osteoarthritis patients can change the knee joint function to a certain extent, and significantly improve the treatment effect, which is worth promoting the application.

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The role of IQGAP1 in podocyte apoptosis in type 2 diabetic nephropathy patients

LUO Qing , KONG Gang

2021, 42(4):  295-297.  DOI: 10.3969/j.issn.1004-7115.2021.04.018

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Objective: To investigate the role and mechanism of IQ domain GTPase activating protein 1 (IQGAP1) in podocyte apoptosis in type 2 diabetic nephropathy patients.Methods: The expression levels of IQGAP1, p-ERK1/2 and ERK1/2 in the two groups were determined by SPSSPearson correlation analysis software. The expression and distribution of IQGAP1 and p-ERK1/2 and ERK1/2 were analyzed by SPSSPearson correlation analysis software.Results: The positive rate of IQGAP1 in the experimental group was lower than that in the control group(P<0.05).The positive rate of p-ERK1/2 and ERK1/2 in the diabetic nephropathy group was higher than that in the control group (P<0.05).The results of immunohistochemistry showed that the podocyte fissures in the diabetic nephropathy group in the experimental group were narrowed, the constriction was narrowed and the segmental fusion was accompanied, and the apoptotic bodies of podocytes were formed.The IQGAP1 was distributed in the glomerular podocytes and mesangium. In the cells and vascular endothelial cells, no renal lesions were observed in the kidney tissues of the control group, and the expression level of IQGAP1 was higher.The results of SPSSPearson correlation analysis showed that the positive rate of IQGAP1, p-ERK1/2 and ERK1/2 protein in the kidney tissue of the experimental group Positive correlation (P<0.05).Conclusion: IQGAP1 is down-regulated in patients with diabetic nephropathy, and the expression level is correlated with p-ERK1/2 and ERK1/2. It may be caused by p-ERK1/2 and ERK1/2, which may cause apoptosis of podocytes.Proteinuria, leads to the development of diabetic nephropathy, though further research and discussion are required .

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Evaluation of the effectiveness of atomizing inhalation acetylcysteine and budesonide in infants with bronchiolitis

PEI Yan-ping, MI Qing, WANG Hui, CAO Ming-yan, WU Gui-ying, SHEN Hui

2021, 42(4):  298-300.  DOI: 10.3969/j.issn.1004-7115.2021.04.019

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Objective: To observe and explore the effectiveness of atomizing inhalation acetylcysteine (ACE) and budesonide (BUD) in infants with bronchiolitis.Methods: 100 infants with bronchiolitis at our hospital from June 2012 to May 2013 were selected, and were randomly divided into two groups, with an equal number of cases in the observation group and the control group. The observation group were treated with atomizing inhalation ACE and BUD on the basis of conventional medicine treatment, while the control group were treated with conventional medicine. Cough relief time, wheeze disappearance time, crackles disappearance time and length of hospital stay in the two groups, as well respiratory rate(before treatment and 24 hours after treament) were evaluated for the efficacy of two groups.Results: Cough relief time, wheeze disappearance time, crackles disappearance time and days of hospitalization in the observation group were(6.25±1.8)d,(2.94±1.05)d,(4.61±1.04) d and(9.19±1.8)d, while was(7.79±1.67)d, (4.46±1.38)d,(5.73±1.46)d and(11.42±1.91)d in the control group, and the difference was statistically significant (P<0.05); before treatment, the difference of respiratory rate in two groups was not statistically significant (P>0.05), the degree of improvement after treatment in observation group was statistically more than that in the control group (P<0.05); the total efficiency of the observation group was 95.8%(46/48), the control group was 66.7%(32/48), and the difference was statistically significant (P<0.05).Conclusion: ACE combine with BUD inhalation therapy can significantly improve lung function in children with bronchiolitis, relieve the clinical response with a significant effect, which thus is a safe and effective treatment for bronchiolitis.

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Clinical study on the effect of Liuwei Dihuang Pill on the pain symptom and bone metabolism in osteoporosis

XU Dong

2021, 42(4):  301-304.  DOI: 10.3969/j.issn.1004-7115.2021.04.020

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Objective: To investigate the clinical effect of Liuwei Dihuang Pill on relieving menopausal osteoporosis pain and improving bone metabolism.Methods: Eighty cases of women with menopausal osteoporosis were chosen and divided into observation group (n=40) and the control group (n=40) by random number table method, control group received continuous oral calcium carbonate + vitamin AD treatment, while the treatment group also had bolus of Liuwei Dihuang Pill on the basis of control group therapy, and the course was 3 months. Visual analog pain score(VAS), digital pain score(NRS), low back function score(JOA), Oswestry disability scale(ODI) changes and the differences of bone metabolism including mineral density(BMD), blood calcium(Ca), blood phosphorus(P) in patients of the two groups were observed.Results: Before treatment, there was no significant difference in pain score and bone metabolism between the two groups (P>0.05).After 3 months of treatment, VAS, NRS, JOA and ODI scores in both groups were reduced, but the improvement of scores in the treatment group was significantly higher than that in the control group, with statistically significant difference (P<0.001). BMD, blood Ca levels in both groups were improved, while the improvement in the treatment group was significantly higher than that in the control group, and the difference was statistically significant(P<0.001).Conclusion: Liuwei Dihuang Pill can effectively improve the clinical symptoms of menopausal osteoporosis pain, and reduce osteoporosis by improving bone metabolism, which has a good clinical effect and is worthy of further study and promotion.

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The diagnostic value and characteristics of PET combined with CT in diffuse large B-cell lymphoma (DLBCL)

FU Li-wu, YOU Bin

2021, 42(4):  305-307.  DOI: 10.3969/j.issn.1004-7115.2021.04.021

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Objective: To explore the value and characteristics of positron emission computed tomography (PET) combined with CT in the diagnosis of DLBCL.Methods: The period from April 2018 to December 2019 was selected as the study interval, and 110 patients with suspected DLBCL admitted to our hospital in this interval were selected as the study objects.All patients received PET/CT examination, their PET /CT results were recorded and compared with the final pathological diagnosis results, and the sensitivity and specificity of PET/CT for DLBCL diagnosis was calculated.Results: In the 110 patients with suspected DLBCL, the detection rate of DLBCL was 91.82% by PET/CT,and the pathological diagnosis rate was 92.73%.Data comparison P>0.05. The sensitivity of PET/CT to DLBCL diagnosis was 98.04%, and the specificity was 87.50%.Conclusion: The application of PET/CT to diagnose DLBCL has high clinical application value.

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Clinical effect of acupuncture combined with medicine in the treatment of acute pancreatitis

DAI Wen-ling

2021, 42(4):  308-311.  DOI: 10.3969/j.issn.1004-7115.2021.04.022

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Objective: To observe the clinical effect of combined Traditional Chinese and western medicine in the treatment of acute pancreatitis (AP).Methods: A total of 70 AP patients admitted from February 2018 to October 2020 were selected and divided into observation group(n=35) and control group(n=35) by random number table method. There was no statistical difference in age, sex, degree of disease and other general information between the two groups.The control group received conventional western medicine treatment, and the observation group was treated with acupuncture therapy combined with Yinchenhao decoction on the basis of the treatment group. Clinical curative effect and the related indicators of change, including the disappearance of the abdominal pain and abdominal distention time, serum amylase and urine amylase recovery time were compared after treatment of the two groups, and the differences of inflammation indexes before and after treatment were observed, including serum c-reactive protein (CRP),procalcitonin(PCT), tumor necrosis factor alpha (TNF-α) expression level.Results: The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.01); the time for abdominal pain, abdominal distension and amylase recovery in the observation group were significantly shorter than that in the control group; the expression levels of serum CRP, PCT and TNF-αthe observation group were significantly lower than those in the control group after treatment, and the differences were statistically significant (P<0.01).Conclusion: Acupuncture therapy combined with Yinchenhao decoction has a definite therapeutic effect on AP, which can quickly relieve clinical and symptoms and reduce the release of inflammatory factors, which can guide further clinical research.

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Clinical observation of Shukoufang in preventing oral fungal infection after inhaled corticostroids

YU Wei-hai, LI Cheng-xia, ZHANG Li-ping

2021, 42(4):  312-314.  DOI: 10.3969/j.issn.1004-7115.2021.04.023

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Objective: To explore the clinical effect of Shukoufang on the prevention of oral fungal infection after inhaled corticosteroids.Methods: The patients who received budesonide suspension and other hormone atomization treatment in Rizhao General Hospital were observed from February 2019 to February 2020.According to the random number table, 72 patients were randomly divided into the control group and the observation group, with 36 cases in each.Among them, the control group rinsed their mouth with water after the hormone atomization treatment, and the observation group with gargle formula after the hormone atomization treatment.Results: The positive rate of pharyngeal swab fungus culture in the observation group was lower than that in the control group (P < 0.05). The infection rate of Candida albicans was 66.67% in the observation group and 64.29% in the control group.Conclusion: Shukoufang has an ideal application effect in the prevention of oral fungal infection after hormone atomization inhalation, which can significantly reduce the risk of fungal infection, and then guarantee the continuous development of patients' atomization inhalation treatment and the efficacy of primary disease treatment.