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25 August 2021, Volume 42 Issue 8

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Basic Researches

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Survey of anxiety and blood pressure control behavior of patients with hypertension in some rural areas of Anhui Province

Jianjian Jiang, Rong Liu, Xingrong Shen, Anan Chen, Ting Zhu, Zhimin Xiao, Debin Wang

2021, 42(8):  561-567.  DOI: 10.3969/j.issn.2097-0005.2021.08.001

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To understand the status of anxiety and blood pressure control behavior of patients with hypertension in parts of rural areas，andto analyze the relations among the anxiety，blood pressure control behavior and blood pressure.

277 patients with hypertension were selected from three administrative villages of Jieshou City in Anhui Province，self-made questionnaire and self-rating anxiety scale（SAS） were used to conduct face to face survey.

The mean of the total score of anxiety scale was （38.27 ± 11.059），the detection rate of anxiety disorders was 14.9%.Comprehensive classification of blood pressure，increase exercise， age group and BMI classification were positively correlated with the total anxiety scores or dimension scores（P < 0.05），but dietcontrol and presence of complications were negatively correlated with the total anxiety scores or dimension scores（P < 0.05）.Dysfunction of the body，dietcontrol，smokingcontrol， moodregulation，going out or not and age group of hypertension diagnosis were positively correlated with comprehensive classification of blood pressure or diastolic and systolic blood pressure levels（P < 0.05），but mood disorder，mixed cross symptom，drinking control and age group were negatively correlated withcomprehensive classification of blood pressure or diastolic and systolic blood pressure levels（P < 0.05）.Comprehensive classification of blood pressure was the hinder factor of control diet（OR = 1.537 or 1.543）.The total anxiety scores was the promotion factor of control diet〔OR（95%CI） = 0.959（0.919～1.000）〕，but was the hinder factor of increasing exercise〔OR（95%CI） = 1.032 （1.004～1.060）〕.Mixed cross symptom is the promotion factor of smokingcontrol〔OR（95%CI）= 0.805（0.683～0.949）〕and drinkingcontrol〔OR（95%CI） = 0.823（0.698～0.971）〕.

Anxiety affects blood pressure， and its behaviorcontrol and blood pressure also affect anxiety and behaviorcontrol.In order to control blood pressure better， we should relieve patients' bad mood and promote the implementation of blood pressure control behavior.

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Expression and significance of Fascin1 and E-cadherin in gastric cancer

Wenxing Zhao, Zhen Wang, Lei Li, Guoqing Yu, Zhen Zheng, Zhimeng Shi

2021, 42(8):  568-572.  DOI: 10.3969/j.issn.2097-0005.2021.08.002

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To investigate the expression of Fascin1 and E-cadherin in gastric cancer and the relationship with the clinicopathological data，and to analyze the regulation relationship between Fascin1 and E-cadherin and the relationshipwith the invasion and metastasis of gastric cancer cells.

The expression of Fascin1 and E-cadherin was detected in gastric cancer and adjacent tissues by immunohistochemical method，and the relationship between the expression of two proteins in gastric cancer and the clinicopathological parameters and the correlation between the two proteins expressionin gastric cancer were analyzed，and the regulatory role ofFascin1 and E-cadherin was further detected in human gastric cancer SGC-7901 cells； The relationship between Fascin1 and invasion and migration of gastric cancer cells was researched by cell experiments.

Theexpression of Fascin1 in gastric cancer tissues was significantly higher than that of paracancerous tissues.The expression of E-cadherin in gastric carcinoma was significantly lower than that of paracancer tissues.The expression of Fascin1 and E-cadherin in gastric cancer was negatively correlated.The expression of Fascin1 and E-cadherin in gastric cancer tissues was not related to sex and age. All of them were associated with TNM stage，lymph node metastasis，and invasion depth. After Fascin1 interference by siRNA，the mRNA and protein expression level of E-cadherin significantly increased in cell experiments，and the invasion and migration ability of cells significantly decreased in SGC-7901 cells.

Fascin1 was highly expressed in gastric cancer，and the expression of E-cadherin is lower in gastric cancer.Both of them are related to metastasis of gastric cancer.Fascin1 has negative regulation on E-cadherin.Fascin1 may be involved in the EMT process of gastric cancer cells and then regulation of the metastasis of gastric cancer.

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Meta-analysis of the curative effect of Gandou Decoction in the treatment of hepatolenticular degeneration

Meiling Chen, Hongling Xiao, Qian Wang, Yunjiu Xiao, Yiting Zhang

2021, 42(8):  573-578.  DOI: 10.3969/j.issn.2097-0005.2021.08.003

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To evaluate the efficacy of Gandou Decoction in the treatment of hepatolenticular degeneration through Meta analysis.

Theonlinesearch for Gandou Decoction for treatment of liver peas and randomized controlled trial study of nucleus degeneration was made in the Chinese Journal Full-text Database （CNKI）， VIP Chinese Science and Technology Journal Full-text Database （VIP）， Chinese Academic Journals Database （Wanfang），Chinese Biomedical Literature Database （CBM），Pubmed in combination with manual search. After selecting the literature according to the inclusion and exclusion criteria，data extraction and quality evaluation，the RevMan5.3 software provided by the Cochrane Collaboration was used for meta-analysis.

A total of 10 RCT studies were included，including 639 patients. The results of Meta analysis showed that Gandou Decoction was better than the western medicine group in terms of total effective rate，improvement of liver function，and 24 h urinary copper excretion in the treatment of hepatolenticular degeneration.

The treatment principle of hepatolenticular degeneration is to drive copper and protect the liver. According to the results of the study，Gandou Decoction has thedefinite effect of removing copper and protecting the liver. However，the current research evidence is still insufficient，and further studies with larger samples and higher quality are needed in the future in order to clarify the therapeutic effect of Gandou Decoction.

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Effect of GATA5 inhibiting EpCAM expression on renal carcinoma HEK-293 cells

Cheng Liu, Song Shi, Wen Chen, Jianmin Guan

2021, 42(8):  579-583.  DOI: 10.3969/j.issn.2097-0005.2021.08.004

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To study the effect of GATA5 on the proliferation regulation of renal cell carcinoma HEK-293 cell line and the expression of cell reprogramming factor EpCAM.

Construction of pTT5-GATA5 expression vector and sequence verification of gene sequence； MTT method to detect cell proliferation rate； cell scratch test to detect cell scratch repair； RT-PCR to detect gene mRNA expression； western blot detect protein expression.

GATA5 inhibits HEK-293 cell proliferation； GATA5 inhibits HEK-293 cell scratch repair； GATA5 inhibits EpCAM mRNA and protein expression.

GATA5 can inhibit the proliferation rate of renal cancer cell HEK-293 cells and inhibit the expression of EpCAM.

Clinical Researches

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The clinical efficacy of metformin combined with diet control exercise therapy in the treatment of community diabetes with high BMI

Yingying Zhang, Chong Zhang, Long Zang

2021, 42(8):  584-587.  DOI: 10.3969/j.issn.2097-0005.2021.08.005

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To explore and analyze the clinical efficacy of metformin combined with diet control exercise therapy in the treatment of community diabetes with high BMI.

Selected 76 cases of community diabetes patients with high BMI from February 2018 to March 2019， the patients were randomly divided into control group （n = 38） and observation group （n = 38），control group simply used metformin treatment，observation group used metformin combined diet control exercise therapy treatment，comparing the treatment effect of two groups of patients.

The fasting blood glucose （FPG） level，2h postprandial blood glucose （2 hPG） level，glycosylated hemoglobin （HbAlc） level，and body mass index （BMI） levels of the observation group were lower than those of the control group （P < 0.05）； the observation group was The total effective rate of the treatment was significantly higher than that of the control group，and the incidence of adverse reactions was lower than that of the control group. The difference between the groups was significant and statistically significant （P < 0.05）.

In the community diabetic patients with high BMI，the use of metformin combined with diet control exercise therapy can effectively reduce the patient's blood glucose level and body mass index level，the incidence of adverse reactions in patients is low， and the clinical treatment effect is significant. High promotion value.

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Analysis of the clinical value of MRI routine sequence combined with DWI and DCE-MRI sequence in the diagnosis of ovarian tumors

Liugeng Qu, Xiaojing Wang

2021, 42(8):  588-591.  DOI: 10.3969/j.issn.2097-0005.2021.08.006

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To analyze its clinical valuein ovarian tumor MRI routine scanning combined with DWI and DCE-MRI sequences.

191 patients with ovarian tumorsincluding 102 benign （benign group） and 89 malignant （malignant group） treated in our hospitalfrom February 2019 to February 2020 were selected，all underwent MRI scan， DWI， DCE-MRI sequence scan，and the DWI parameters， TIC image types， DCE-MRI parameters and diagnosis results of the two groups of patientswere compared.

The ADC values of the solid and cystic parts of the benign group were significantly higher than those of the malignant group （P < 0.05）； the TIC image of the benign group was mainly type Ⅰ （91.18%）， and the malignant group was mainly type Ⅲ （86.52%）. The difference was obvious （P < 0.05）； the Ktrans，Kep， Ve and other DCE-MRI parameters of the benign group were significantly lower than those of the control group （P <0.05）； There was no significant difference in the degreeof the sensitivity， specificity and accuracy of the MRI routine sequence combined with DWI and DCE-MRI （P > 0.05）.

MRI routine sequence combined with DWI and DCE-MRI sequence can achieve good diagnostic results，and it is worthy of promotion.

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Effect of Qiliqiangxin Capsule on Serum FGF-23 level and cardiac function in patients with left ventricular hypertrophy on maintenance hemodialysis

Qian Peng, Lanye Jiang, Meiying Chen, Yanxia Zhou

2021, 42(8):  592-594.  DOI: 10.3969/j.issn.2097-0005.2021.08.007

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To investigate the expression of serum FGF-23 （fibroblast growth factor-23，FGF-23） in patients with left ventricular hypertrophy on maintenance hemodialysis after treatment with Qiliqiangxin Capsule and its effect on cardiac function.

Forty-two patients with chronic kidney disease stage 5 who were on maintenance hemodialysis in our hospital's hemodialysis center from January 2017 to December 2018 were selected，and divided into two groups according to the random number method. The control group had 17 cases and the treatment group had 25 cases. Patients in the control group were given basic treatment.The treatment group was given Qiliqiangxin Capsule on the basis of basic treatment. By comparing with the control group，the improvement of cardiac function，the change of serum FGF-23，and the left ventricular mass index of patients after 12 weeks of treatment with Qiliqiangxin Capsule were analyzed，and the relevant data were analyzed statistically.

In patients in the treatment group，after 12 weeks of treatment with Qiliqiangxin Capsule，serum FGF-23 levels in CKD stage 5 patients with left ventricular hypertrophy decreased.The difference between the two groups was statistically significant （P < 0.05）. the cardiac function of the treatment group was significantly improved，and the difference was significantly better than that of the control group. The difference was statistically significant（P < 0.05）.

Qiliqiangxin Capsule can down-regulate the serum FGF-23 level in patients with CKD stage 5 left ventricular hypertrophy and improve their cardiac function.

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Effects of cisatracurium， propofol and sevoflurane anesthesia on postoperative cognitive function in elderly patients undergoing laparoscopic surgery

Xingdui Ma, Longjian Yan, Liang Wu, Yingying Yao, Xiufang Li, Deling Wang, Beiping Li

2021, 42(8):  595-597.  DOI: 10.3969/j.issn.2097-0005.2021.08.008

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To discuss the effect of the compatibility of cisatracurium， propofol and sevoflurane on postoperative cognitive function in elderly patients undergoing laparoscopic surgery.

Control group to rui fentanyl compatibility isoflurane and imidazole stable anesthesia， the team is pump injection along the benzene sulfonic acid cisatracurium， propofol and sevoflurane anesthesia， the postoperative recovery status， pain VAS score and cognitive function MMSE score changes were compared between the two groups.

The directional power recovery， eye opening and spontaneous breathing time of the elderly patients in the study group were significantly shorter than those in the control group， with statistically significant differences （t = 4.476， 3.921， 6.730， P < 0.05）.Compared with the control group， there was no significant difference in MMSE score of cognitive function between the study group and the control group before anesthesia （P > 0.05）.At 2 h， 12 h and 24 h postoperatively， MMSE scores of patients in the study group were more significantly increased than those in the control group， and 12 h postoperatively， MMSE scores of cognitive function were close to the preoperative status， with statistically significant differences from the control group （P < 0.05）； The VAS scores of the study group at different time points after operation were lower than those of the control group， and the difference was statistically significant （P < 0.05）.

Cisatracurium cisplatin and sevoflurane， three different anesthetic drugs， can significantly improve postoperative cognitive function and speed up the recovery of patients.

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The effect of volume rotation intensity-modulated radiotherapy （VMRT） in patients with glioma

Junping Huang, Zhiyu Zhou, Changji Xie, Huan Lan, Guang Li

2021, 42(8):  598-601.  DOI: 10.3969/j.issn.2097-0005.2021.08.009

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To analyze their therapeutic effects ofVMRT and IMRT on patients with glioma.

Ninety-four patients with glioma treated in our hospital from February 2018 to April 2019 were selectedand divided them into two groups. There were 47 cases in the control group and 47 cases in the control group；the 47 cases in the observation group were treated with VMRT. The HI，CI，clinical efficacy and survival rate of the two groups of patients were compared.

The CI of the observation group was higher than that of the control group（P < 0.05），and there was no significant difference in HI between the two groups（P > 0.05）；the objective remission rate of the observation group was 80.85%，and the control group was 61.70%. The difference was significant （P < 0.05）；the half-year，one-year，and two-year survival rates of the observation group were 80.85%，72.34%，and 53.19%， respectively， and the control group were 59.57%，42.55%，and 29.79%，respectively，with significant differences （P < 0.05） .

The CI of VMRT is better than IMRT for patients with glioma. The objective response rate is higher and the survival rate within 2 years is higher， which is worthy of promotion.

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Effect of Tongfuxiaoduyin enema and external application combined with esomeprazole on intestinal mucosal barrier function and inflammatory state in patients with severe acute pancreatitis

Zhongli Wei

2021, 42(8):  602-605.  DOI: 10.3969/j.issn.2097-0005.2021.08.010

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To explore the effect of Tongfuxiaoduyin enema and external application combined with esomeprazole in the treatment of severe acute pancreatitis，and to explore the effect of it on intestinal mucosal barrier function and inflammatory state of patients.

Ninety patients with severe acute pancreatitis were randomly divided into control group and observation group，with 45 patients in each group. The control group was treated with esomeprazole，and the observation group was additionally treated with Tongfuxiaoduyin enema and external application on the basis of the treatment in the control group. The treatment lasted for 7 days. The severity of the disease， intestinal mucosal barrier function and inflammatory status were compared between the two groups.

Compared with the control group，the Apache score and Balthazar CT score in the observation group were significantly decreased after treatment，with statistical significance （P < 0.05）. Compared with the control group，the indexes of intestinal mucosal barrier function （D-lactic acid，AMS，DAO） decreased more significantly in the observation group after treatment，with statistical significance （P < 0.05）. Compared with the control group，the serum inflammatory state related indexes of SICAM-1 and MCP-1 in the observation group decreased more obviously after treatment，while the content of MFG-E8 increased more obviously，the difference was statistically significant （P < 0.05）.

Tongfuxiaoduyin enema and external application combined with esomeprazole is more conducive to reduce the severity of patients with acute pancreatitis，promote the recovery of intestinal mucosal barrier function and improve the prognosis，whose effect may be related to the inhibition of SICAM-1，MCP-1 expression，promotion of the secretion of MFG-E8 to reduce inflammatory response and protection of the intestinal barrier，which is worthy of clinical application.

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The effect of one day outpatient on patients with gestational diabetes mellitus

Lixia Shi

2021, 42(8):  606-609.  DOI: 10.3969/j.issn.2097-0005.2021.08.011

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To investigate the effect of one day outpatient management patients with gestational diabetes mellitus（GDM）.

The experimental group received the one day outpatient，including receiving medical education， moderate exercise and diet control.The control group was given routine care. Blood glucose，the incidence of mother-baby complication and bad pregnancy outcome ofthe two groups of were compared after intervention.

The level of blood glucose and the incidence of pregnancy and bad pregnancy outcome were less than those of the control group， which had significant difference（P < 0.05）.

After the one day outpatient diagnosis and treatment of GDM patients experience， the standard rate of blood glucose is high，complications of mother and baby are fewer， and mother and baby have a good ending， which is an effective group management mode to save medical resources.

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Clinical medical research of bi-level positive airyway pressure in moderate to severe capillary bronchiotis

Gongli Li, Minmin Duan, Delei Zhang

2021, 42(8):  610-612.  DOI: 10.3969/j.issn.2097-0005.2021.08.012

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To investigate the clinical efficacy of bi-level positive airway pressure（BiPAP） in moderate to severe capillary bronchiotis.

120 children with moderate to severe capillary bronchiotis in The Second Affiliated Hospital of Shandong First Medical University from November 2016 to March 2019 were selected and divided into treatment group（n = 60） and conventional group（n = 60）. Arterial blood gas analysis， lactic acid，the clinical manifestations，the proportion of need forendobronchial intubation and time in PICU were recorded and compared.

After 24 hours treatment， arterial blood gas analysis，heart rate and respiratory rate were greatly improved in cases with BiPAP than those in cases with conventional oxygen（P < 0.05）. the differences in needing endobronchial intubation rate and time in PICU were statistically significant between the 2 groups（P < 0.05）.

The early use of BiPAP for eligible patients can improve clinical symptoms and signs of moderate to severe capillary bronchiotis in children， rectify blood gas，and can shorten length of hospital stay.

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Effect of bilateral uterine artery embolization combined with hysteroscopic electrotomy on cesarean scar pregnancy （CSP）

Lijun Hu

2021, 42(8):  613-616.  DOI: 10.3969/j.issn.2097-0005.2021.08.013

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To study and analyze the therapeutic effect of BUAE （bilateral uterine artery embolization） combined with traditional cervicotomy and BUAE combined with hysteroscopic electrotomy in patients with cesarean section scar pregnancy.

126 patients with cesarean section scar pregnancy received by our hospital from March 2019 to March 2020 were taken as observation subjects.According to the double-blind randomized control principle，the study group was divided into two groups， one group was the conventional group （BUAE combined with traditional palace clearance） and the other group was the experimental group （BUAE combined with hysteroscopic electrotomy）.Each group had 63 cases.The surgical efficacy of the two groups was compared.

The success rate of the study group was higher than that of the conventional group （P < 0.05）.The amount of surgical blood loss in the study group was lower than that in the conventional group， and the operation time， menstrual cycle recovery time，serum-HCG（a subunit of human chorionic gonadotropin） recovery time and hospitalization time were shorter than those in the conventional group （P < 0.05）.Postoperative complications in the study group were less than those in the conventional group （P < 0.05）.

Compared with traditional hysterectomy combined with BUAE， hysteroscopy combined with BUAE for cesarean section scar pregnancy patients has many advantages， such as outstanding efficacy， low blood loss， fewer postoperative complications， high safety and fast recovery， which is worth popularizing in clinic.

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Application of closed drainage with negative pressure combined with perforator flap transplantation in the treatment of soft tissue defect of foot and ankle

Xinqiang Jiang, Fang Zhang

2021, 42(8):  617-620.  DOI: 10.3969/j.issn.2097-0005.2021.08.014

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To observe the effect of negative pressure closed drainage （VSD） combined with perforator flap transplantation in the treatment of ankle soft tissue defect.

Sixty cases of soft tissue defect of the ankle were from our hospital from May 2018 to May 2020. There were 30 cases in the observation group （VSD + perforator flap transplantation） and the control group （traditional wound + perforator flap transplantation）respectively.Treatment related indicators，ankle function score （Kphoed），pain score （VAS），treatment effect，and incidence of complications were compared between the two groups before and after treatment.

Compared with the control group，the duration of surgery，antibiotic application and hospitalization in the observation group was shorter，and the number of dressing changes and the area of skin flap incision in the observation group were less than those in the control group，with statistically significant differences （P < 0.05）；After treatment，Kphoed scores of patients in both groups were improved，while VAS scores were decreased，which were better than those before treatment， and statistically significant （P < 0.05）；The total effective rate of 93.3% in the observation group was higher than that of 70.0% in the control group，which was statistically significant （P < 0.05）； In the comparison of complication rates between the two groups， the observation group was lower than the control group （6.7% vs 26.7%） （P < 0.05）.

VSD combined with perforator flap transplantation plays a significant role in improving patients' psychological status and quality of life，which is conducive to reduce the occurrence of adverse events，and can be widely promoted in clinical practice.

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Therapeutic effect of asarone injection and budesonide combined with ipratropium bromide inhalation on adult asthma

Huanhuan Wang

2021, 42(8):  621-624.  DOI: 10.3969/j.issn.2097-0005.2021.08.015

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To observe the clinical effect of asarinol injectionand budesonide combined with ipratropium bromide inhalation in the treatment of adult asthma.

Ninety adult patients with asthma in the Respiratory Departmentof Guannan County People's Hospital from January 2018 to January 2020 were selected and divided into control group （n = 45） and observation group （n = 45） according to random number table method. The control group was given budesonide combined with ipratropium bromide inhalation treatment，and the observation group was given asarinol injection intravenous infusion on the basis of the control group. The clinical efficacy， disappearance time of symptoms and signs， lung function， SaO₂， SF-36 score and airway inflammation indexes were compared between the two groups.

In terms of the total effective rate， 95.56% in the observation group was significantly higher than 80.00% in the control group （χ² =5.075， P < 0.05）. The time of asthma disappearance， rales， wheezing and cough disappearance in observation group were significantly shorter than those in control group （P < 0.05）. After treatment， the increase rates of FEV1， FVC and PEF in observation group were significantly higher than those in control group （P < 0.05）. After treatment， RR decreased， SaO₂ and SF-36 scores increased in the observation group compared with those in the control group， with statistical significance （P < 0.05）. Compared with the control group， airway inflammatory indexes S1P and TNF-α in observation group were significantly decreased （P < 0.05）.

Asarineol injectionand budesonide combined with ipratropium bromide inhalation treatment of adult asthma has definite clinical effect. It is more conducive to promotion of the relief of symptoms， improvement of lung function and quality of lifeand reduce airway inflammation， which is worthy of clinical promotion.

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Effect of epidural anesthesia combined with general anesthesia on perioperative hemodynamic changes and postoperative cognitive function in elderly patients undergoing abdominal surgery

Luhua MA, Changlu Zheng

2021, 42(8):  625-627.  DOI: 10.3969/j.issn.2097-0005.2021.08.016

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To analyze the effects of epidural anesthesia combined with general anesthesia and general anesthesia on postoperative cognitive function and perioperative hemodynamic changes in elderly patients undergoing abdominal surgery.

From October 2018 to January 2020，80 elderly patients with abdominal surgery were selected. According to the group of odd-even patients，40 patients with single number were selected as the control group and 40 patients with double number as the experimental group.General anesthesia was used in the control group and epidural anesthesia combined with general anesthesia in the experimental group.HR，MAP，HS-CRP，IL-6，MMSE score change and recovery were compared between the two groups.

Comparing the levels of HR and MAP in the two groups at T₁～T₄，it was found that the test group was significantly better than the control group （P < 0.05）， with statistical value.Comparison of postoperative HS-CRP，IL-6 and MMSE scores between the two groups showed that the experimental group was significantly better than the control group （P < 0.05），with statistical value.

The efficacy of epidural anesthesia combined with general anesthesia in elderly patients undergoing abdominal surgery is better，which can maintain the perioperative hemodynamic stability，inhibit the inflammatory response to stress，and improve the postoperative cognitive function， which is worthy of popularization and research.

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Modified transurethral plasma resection of prostate in the treatment of high risk prostatic hyperplasia

Haiming Zhai

2021, 42(8):  628-631.  DOI: 10.3969/j.issn.2097-0005.2021.08.017

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To study the application effect of modified transurethral plasma resection of prostate in the treatment of high-risk prostatic hyperplasia.

A total of 80 high-risk patients with BPH admitted to our hospital from June 2019 to July 2020 were randomly divided into control group and observation group with 40 patients in each group.Forty patients in the control group were treated with conventional transurethral prostatic plasma electrotomy， while 40 patients in the observation group were treated with modified transurethral prostatic plasma electrotomy.Then statistical analysis was made on surgical indicators，Q-MAX，IPSS score，PVR，QOL score， postoperative complications and satisfaction of patients in the two groups.

The operation time and hospitalization time of patients in the observation group were significantly shorter than those in the control group， and the differences between the groups were statistically significant （P < 0.05）. The amount of intraoperative bleeding and blood transfusion in the observation group were significantly less than those in the control group， and the differences between the groups were statistically significant （P < 0.05）.The increase of Q-MAX，QOL score，IPSS score and PVR in the observation group were significantly higher than those in the control group （P < 0.05）.The incidence of postoperative complications was 2.50% （1/40） in the observation group and 22.50% （9/40） in the control group，with the former significantly lower than the latter （P < 0.05）.In terms of satisfaction，the observation group was 92.50% （37/40） and the control group was 75.00% （30/40），the former was significantly higher than the latter （P <0.05）.

The modified transurethral plasma resection of prostate is very effective in the treatment of high risk prostatic hyperplasia，so it is worth promoting in the treatment of high risk prostatic hyperplasia patients.

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The changes of growth hormone insulin-like growth factor axis in the children with congenital heart disease

Jihui Yin, Bin Zhang, Aihua Zhang

2021, 42(8):  632-634.  DOI: 10.3969/j.issn.2097-0005.2021.08.018

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To investigate the change of growth hormone insulin-like growth factor（GH-IGF） axis in the children with congenital heart disease（CHD）.

The serum growth hormone（GH）， insulin-like growth factor-1（IGF-1） and insulin-like growth factor binding protein-3（IGFBP-3） in fifty-three children with CHD（Low risk group/medium risk group and high risk group）and 30 normal children were measured.

The levels of serum GH， IGF-1 and IGFBP-3 were decreased in the patients with CHD； The birth weight，the hospital weight，the levels of serum GH， IGF-1 and IGFBP-3 were all different in the three groups. The birth weight，the hospital weight，the levels of serum GH， IGF-1 and IGFBP-3 in the low risk group and medium risk group were significantly higher than in the high risk group.

The levels of serum GH， IGF-1 and IGFBP-3 were significantly different in different groups， especially in the high risk group. The high risk group may have intrauterine growth retardation.

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Surgical treatment of multiple breast fibroma through the incision of the lower border of the breast and the posterior interspace approach

Pingping Wang, Jing Xiang, Wenzhen Zhang

2021, 42(8):  635-637.  DOI: 10.3969/j.issn.2097-0005.2021.08.019

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To explore the curative effect of multiple breast fibroma by posterior space approach through the incision of the lower margin of the breast.

Ninety-eight patients with breast fibroma were selectedfrom March 2019 to February 2020 as the study object and divided into the control group and the observation groupaccording to the different choices of surgical approach，with 49 cases in each group. The control group was treated with traditional surgery，and the observation group was treated with posterior space approach. The curative effect of different operation，perioperative index and incision beauty score were compared.

The total effective rate of the observation group was similar to that of the control group （P > 0.05）. The operation time and hospital recovery time of the observation group were shorter than those of the control group （P < 0.05）. The score of incision beauty degree in the observation group was higher than that in the control group （P < 0.05）.

The lower margin incision through the posterior space of the breast is an ideal approach for the treatment of multiple breast fibroma， with fast postoperative recovery，high aesthetic incision and high application value.

Review

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Research progress of quadruple therapy for eradication of Helicobacter pylori

Xinxiang Yu, Linlin Li, Ningning Peng, Weilin Wang, Binglong Li, Yongxiu Qi

2021, 42(8):  638-640.  DOI: 10.3969/j.issn.2097-0005.2021.08.020

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Helicobacter pylori is a worldwide pathogen of human infection，which can cause gastrointestinal diseases and lead to the occurrence of gastric cancer. It has been listed as a kind of carcinogen by the InternationalAgency for Research on Cancer of the World Health Organization. Therefore， eradicating Hp infection is an inevitable problem for clinicians. With the continuous progress of Hp eradication treatment， the current clinical first-line treatment has developed into quadruple therapy. This study will focus on quadruple therapy，explore its therapeutic mechanism and the latest combined therapy，and provide a certain theoretical basis for clinical treatment.