微小RNA调控肿瘤相关巨噬细胞极化在重塑乳腺癌免疫微环境中的作用

国际肿瘤学杂志››2020,Vol. 47››Issue (7): 428-430.doi:10.3760/cma.j.cn371439-20200401-00050

微小RNA调控肿瘤相关巨噬细胞极化在重塑乳腺癌免疫微环境中的作用

周佳敏, 叶莉莎, 王国华()

南通大学特种医学研究院 226001

收稿日期:2020-04-01修回日期:2020-04-10出版日期:2020-07-08发布日期:2020-08-18
通讯作者:王国华 E-mail:wgh@ntu.edu.cn
基金资助:
国家自然科学基金(81471257);江苏省重点研发计划(BE2018778);江苏省第五期“333工程”科研项目(BAR2019207);南通市科技计划(MS12018029)

Roles of microRNA in the regulation of tumor-associated macrophage polarization during the remodeling of breast cancer immune microenvironment

Zhou Jiamin, Ye Lisha, Wang Guohua()

Institute of Special Environmental Medicine, Nantong University, Nantong 226001, China

Received:2020-04-01Revised:2020-04-10Online:2020-07-08Published:2020-08-18
Contact:Wang Guohua E-mail:wgh@ntu.edu.cn
Supported by:
National Natural Science Foundation of China(81471257);Primary Research and Development Plan of Jiangsu Province(BE2018778);The Fifth "333 Project" of Jiangsu Province(BAR2019207);Nantong Science and Technology Plan(MS12018029)

摘要/Abstract

摘要：

肿瘤相关巨噬细胞(TAM)作为肿瘤微环境中的主要免疫细胞已成为乳腺癌进展的重要参与者。微小RNA(miRNA)可调控转录后基因表达而改变TAM功能,影响其极化分型及转化,最终影响乳腺癌的发生、发展。了解miRNA在TAM极化中的作用机制,可为乳腺癌的治疗提供新的诊断思路与临床治疗策略。

关键词:乳腺肿瘤,肿瘤微环境,巨噬细胞,微RNAs

Abstract:

Tumor associated macrophage (TAM), as the main type of immune cells in tumor microenvironment, becomes an active participant in the development of breast cancer. MicroRNA (miRNA) can regulate post-transcriptional gene expression, modulation of macrophage function by affecting its polarization typing and transformation, and ultimately contribute to the occurrence and development of breast cancer. It could provide a new diagnosis and clinical treatment strategy for the treatment of breast cancer by summarizing the mechanisms of miRNA in the polarization of TAM.

Key words:Breast neoplasms,Tumor microenvironment,Macrophages,MicroRNAs

周佳敏, 叶莉莎, 王国华. 微小RNA调控肿瘤相关巨噬细胞极化在重塑乳腺癌免疫微环境中的作用[J]. 国际肿瘤学杂志, 2020, 47(7): 428-430.

Zhou Jiamin, Ye Lisha, Wang Guohua. Roles of microRNA in the regulation of tumor-associated macrophage polarization during the remodeling of breast cancer immune microenvironment[J]. Journal of International Oncology, 2020, 47(7): 428-430.

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