NOD2基因与原发性肝癌

摘要/Abstract

摘要：核苷酸结合寡聚化结构域蛋白2（NOD2）可通过识别细菌细胞壁的肽聚糖及其裂解产物胞壁酰二肽，参与宿主对病原体的免疫应答，参与调节自然免疫和特异性免疫。NOD2作为一种新发现的细胞内模式识别受体，可通过基因变异、诱发肝脏炎症反应、激活相应信号通路在原发性肝癌的发生发展中发挥重要作用。

梁宁, 乔丽丽, 谢健, 张建东. NOD2基因与原发性肝癌[J]. 国际肿瘤学杂志, 2013, 40(12): 927-929.

LIANG Ning, QIAO Li-Li, XIE Jian, ZHANG Jian-Dong. NOD2 gene and primary hepatocellular carcinoma[J]. Journal of International Oncology, 2013, 40(12): 927-929.

［1］ Correa RG, Milutinovic S, Reed JC. Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases. Biosci Rep, 2012, 32(6): 597608. ［2］ Chen F, Liu Y, Zhu H, et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotidebinding oligomerization domain protein signaling pathways. Innate Immun, 2013, 19(5): 504515. ［3］ Fukata M, Vamadevan AS, Abreu MT. Tolllike receptors (TLRs) and Nodlike receptors (NLRs) in inflammatory disorders. Semin Immunol, 2009, 21(4): 242253. ［4］ Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell, 2010, 140(6): 805820. ［5］ Scott MJ, Chen C, Sun Q, et al. Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production. J Hepatol, 2010, 53(4): 693701. ［6］ Kutikhin AG. Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology. Hum Immunol, 2011, 72(10): 955968. ［7］ Chen G, Shaw MH, Kim YG, et al. NODlike receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol, 2009, 4: 365398. ［8］ Kumar H, Kawai T, Akira S. Pathogen recognition in the innate immune response. Biochem J, 2009, 420(1): 116. ［9］ Rüegg C, Hersberger M, Wusk B, et al. Detection of the Arg702Trp, Gly908Arg and Leu1007fsinsC polymorphisms of the NOD2/CARD15 gene by realtime PCR with melting curve analysis. Clin Chem Lab Med, 2004, 42(5): 494498. ［10］ Kutikhin AG. Impact of Tolllike receptor 4 polymorphisms on risk of cancer. Hum Immunol, 2011, 72(2): 193206. ［11］ Castellaneta A, Sumpter TL, Chen L, et al. NOD2 ligation subverts IFNalpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7H1 upregulation. J Immunol, 2009, 183(11): 69226932. ［12］ Nahid MA, Yao B, DominguezGutierrez PR, et al. Regulation of TLR2mediated tolerance and crosstolerance through IRAK4 modulation by miR132 and miR212. J Immunol, 2013, 190(3): 12501263. ［13］ Watanabe T, Asano N, Murray PJ, et al. Muramyl dipeptide activation of nucleotidebinding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest, 2008, 118(2): 545559. ［14］ EI Chartouni C, Schwarzfischer L, Rehli M. Interleukin4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming. Immunobiology, 2010, 215(910): 821825. ［15］ Crispe IN. The liver as a lymphoid organ. Annu Rev Immunol, 2009, 27: 147163. ［16］ SánchezFueyo A. Identification of tolerant recipients following liver transplantation. Int Immunopharmacol, 2010, 10(12): 15011504. ［17］ Bhama JK, Pilewski JM, Zaldonis D, et al. Does simultaneous lungliver transplantation provide an immunologic advantage compared with isolated lung transplantation?. J Thorac Cardiovasc Surg, 2011, 141(5): e3638. ［18］ Ezzelarab M, Thomson AW. Tolerogenic dendritic cells and their role in transplantation. Semin Immunol, 2011, 23(4): 252263. ［19］ Goubier A, Dubois B, Gheit H, et al. Plasmacytoid dendritic cells mediate oral tolerance. Immunity, 2008, 29(3): 464475. ［20］ Bamboat ZM, Stableford JA, Plitas G, et al. Human liver dendritic cells promote T cell hyporesponsiveness. J Immunol, 2009, 182(4): 19011911. ［21］ Reiberger T, Ferlitsch A, Payer BA, et al. Nonselective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL6 in patients with cirrhosis. J Hepatol, 2013, 58(5): 911921. ［22］ Liu X, Chauhan VS, Marriott I. NOD2 contributes to the inflammatory responses of primary murine microglia and astrocytes to Staphylococcus aureus. Neurosci Lett, 2010, 474(2): 9398. ［23］ BillmannBorn S, Till A, Arlt A, et al. Genomewide expression profiling identifies an impairment of negative feedback signals in the Crohn′s diseaseassociated NOD2 variant L1007fsinsC. J Immunol, 2011, 186(7): 40274038. ［24］ Piva MR, DE Souza LB, MartinsFilho PR, et al. Role of inflammation in oral carcinogenesis (Part Ⅱ): CD8, FOXP3, TNFα, TGFβ and NFκB expression. Oncol Lett, 2013, 5(6): 19091914. ［25］ Calorini L, Peppicelli S, Bianchini F. Extracellular acidity as favouring factor of tumor progression and metastatic dissemination. Exp Oncol, 2012, 34(2): 7984. ［26］ Sakuma Y, Yamazaki Y, Nakamura Y, et al. NFκB signaling is activated and confers resistance to apoptosis in threedimensionally cultured EGFRmutant lung adenocarcinoma cells. Biochem Biophys Res Commun, 2012, 423(4): 667671. ［27］ Matsuda T, Shimada M, Sato A, et al. Tumor necrosis factoralphanuclear factorkappa Bsignaling enhances St2b2 expression during 12Otetradecanoylphorbol13acetateinduced epidermal hyperplasia. Biol Pharm Bull, 2011, 34(2): 183190.

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NOD2 gene and primary hepatocellular carcinoma

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