人8-羟基鸟嘌呤DNA糖苷酶1与肺癌

国际肿瘤学杂志››2014,Vol. 41››Issue (5): 341-344.doi:10.3760/cma.j.issn.1673-422X.2014.05.007

人8-羟基鸟嘌呤DNA糖苷酶1与肺癌

宾流,林子英,杨拉维,刘刚

524001湛江，广东医学院附属医院呼吸内科

收稿日期:2013-12-25修回日期:2014-01-14出版日期:2014-05-08发布日期:2014-04-28
通讯作者:刘刚 E-mail:gangliu11@gdmc.edu.cn
基金资助:

国家自然科学基金（81172615）

Human 8-oxoguanine DNA glycosylase and lung cancer

Bin Liu, Lin Ziying, Yang Lawei, Liu Gang

Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China

Received:2013-12-25Revised:2014-01-14Online:2014-05-08Published:2014-04-28
Contact:Liu Gang E-mail:gangliu11@gdmc.edu.cn

摘要/Abstract

摘要：人8-羟基鸟嘌呤DNA糖苷酶1（hOGG1）功能异常与肺癌等癌症发生发展密切相关，hOGG1基因多态性可能会改变酶的活性，从而影响个体损伤DNA的修复能力，促进癌变。hOGG1等DNA修复基因单核苷酸多态性联合效应提高人群肺癌的易感性。hOGG1参与调节肿瘤细胞的线粒体呼吸功能并影响肿瘤细胞生长。

宾流,林子英,杨拉维,刘刚. 人8-羟基鸟嘌呤DNA糖苷酶1与肺癌[J]. 国际肿瘤学杂志, 2014, 41(5): 341-344.

Bin Liu, Lin Ziying, Yang Lawei, Liu Gang. Human 8-oxoguanine DNA glycosylase and lung cancer[J]. Journal of International Oncology, 2014, 41(5): 341-344.

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