姜黄素类似物EF24的抗肿瘤机制与应用

国际肿瘤学杂志››2018,Vol. 45››Issue (3): 172-175.doi:10.3760/cma.j.issn.1673-422X.2018.03.010

姜黄素类似物EF24的抗肿瘤机制与应用

凌晓斐，胥可，邵华，王翠娟

250062 济南大学 betway.com 医学与生命科学学院(凌晓斐、胥可)；betway.com 山东省职业卫生与职业病防治研究院理化实验室（凌晓斐、胥可、邵华、王翠娟）

收稿日期:2017-12-22出版日期:2018-03-08发布日期:2018-05-16
通讯作者:邵华，Email: chinashaohua5888@163.com；王翠娟，Email: iamcuijuan@163.com E-mail:邵华，Email: chinashaohua5888@163.com；王翠娟，Email: iamcuijuan@163.com

Anticancer mechanism and application of curcumin analog EF24

Ling Xiaofei, Xu Ke, Shao Hua, Wang Cuijuan

School of Medicine and Life Sciences, University of Ji′nanShandong Academy of Medical Sciences; Physics and Chemistry Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Ji′nan 250062, China

Received:2017-12-22Online:2018-03-08Published:2018-05-16
Contact:邵华，Email: chinashaohua5888@163.com；王翠娟，Email: iamcuijuan@163.com E-mail:邵华，Email: chinashaohua5888@163.com；王翠娟，Email: iamcuijuan@163.com

摘要/Abstract

摘要：姜黄素是从姜黄属植物姜黄根茎中提取的酚性色素，具有抗氧化、抗炎、抗肿瘤等多方面药理作用。研究表明，联苯二氟铜（EF24）是一种新型姜黄素类似物，EF24可以诱导肿瘤细胞凋亡、阻滞细胞周期、抑制细胞侵袭与转移，与其他药物联合使用时具有增敏效果，在不增加细胞毒性的情况下，在多种肿瘤细胞株中表现出比姜黄素更高的抗肿瘤活性与生物利用度，有望作为一种具有潜力的抗癌新药。

关键词:抗肿瘤药,姜黄素,联苯二氟铜

Abstract:Curcumin is a polyphenol pigment product from the rhizome of curcumin longa. It is associated with numerous therapeutic benefits, including antioxidant, antiinflammatory and anticancer activities. Research shows that EF24 is a curcumin analog that can induce tumor cell apoptosis, arrest cell cycle, inhibit cell invasion and metastasis and has synergistic effect of combined antitumor agents. EF24 has improved anticancer activity and bioavailability against various cancer cell lines over curcumin without increased toxicity. EF24 would have great potential to be used as a useful therapeutic agent for the treatment of various types of cancer.

Key words:Antineoplastic agents,Curcumin,EF24

凌晓斐，胥可，邵华，王翠娟. 姜黄素类似物EF24的抗肿瘤机制与应用 [J]. 国际肿瘤学杂志, 2018, 45(3): 172-175.

Ling Xiaofei, Xu Ke, Shao Hua, Wang Cuijuan. Anticancer mechanism and application of curcumin analog EF24[J]. Journal of International Oncology, 2018, 45(3): 172-175.

参考文献

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