Abstract:Recent findings indicate that metastasis-associated gene in colon cancer 1 (MACC1)has an abnormal high expressionin most malignant tumors. As a key regulator of HGF-MET signal pathway, MACC1 could obviously up-regulate the expression of MET and promote cancer cell’s movement, invasion and metastasis. Further studies willshed light onelucidating the mechanisms of metastasis and may provide a new method for targeted therapy.