国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (2): 137-139.

• 综述 •上一篇下一篇

DNA甲基化与胃癌的相关性

罗君, 凌志强

  1. 310022杭州， 浙江省肿瘤医院 浙江省肿瘤研究所
  • 出版日期:2012-02-08发布日期:2012-01-18
  • 通讯作者:凌志强，E-mail:lingzq@hotmail.com E-mail:lingzq@hotmail.com
  • 基金资助:

    浙江省科技计划资助项目（No .2009C 33143）

DNA methylation and gastric cancer

LUO Jun, LING Zhi-Qiang

  1. Zhejiang Cancer Research Institute ,Zhejiang Province Cancer Hospital , Hangzhou ,310022,China
  • Online:2012-02-08Published:2012-01-18
  • Contact:Corresponding author: LING Zhi-qiang, E-mail: lingzq@hotmail.com E-mail:lingzq@hotmail.com

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摘要：在胃癌的发展过程中常发现肿瘤相关基因的异常甲基化存在，其中包括全基因组的低甲基化和某些抑癌基因的高甲基化。另外，DNA甲基化水平似乎还与胃癌的预后密切相关。近年来人们为揭示DNA甲基化与胃癌的相关性进行了大量研究。

Abstract:Abnormal methylation of the tumor-related genesis frequently found in the development of gastric cancer. Cancer cells exhibit two opposing methylation abnormalities: genome-wide hypomethylation and certain tumor suppressor gene hypermethylation. Furthermore, it seems that the level of DNA methylation is closely associated with the prognosis of gastric cancer. Recently, a great deal of research has been conducted to reveal thecorelation of DNA methylation and gastric cancer.