国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (2): 83-85.

• 综述 •下一篇

TC-1蛋白表达在肿瘤发生发展过程中的作用

张琪瑶, 徐洪涛

  1. 110001沈阳，中国医科大学基础医学院病理学教研室
  • 出版日期:2012-02-08发布日期:2012-01-18
  • 通讯作者:徐洪涛，E-mail: htxu@mail.cmu.edu.cn E-mail:htxu@mail.cmu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目（30801135）

Role of thyroid cancer-1 in tumorigenesis and progression

ZHANG Qi-Yao, XU Hong-Tao

  1. Department of Pathology, College of Basic Medical Sciences,ChinaMedical University,Shenyang 110001,China
  • Online:2012-02-08Published:2012-01-18
  • Contact:Corresponding author: XU Hong-tao, E-mail: htxu@mail.cmu.edu.cn E-mail:htxu@mail.cmu.edu.cn

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摘要：TC-1是由TC-1基因编码的核蛋白，能够调控细胞分裂周期，参与基因转录和翻译的调节，与正常细胞和肿瘤细胞的增殖有关。TC-1参与Wnt信号转导通路的激活，可以促进多种癌基因表达上调，与甲状腺癌、胃癌、乳腺癌等肿瘤的恶性转化和进展有关。TC-1作为一种潜在的肿瘤相关蛋白，将有望用于肿瘤的基础理论研究和基因靶向治疗。

关键词:肿瘤&Iota,基因&Iota,信号传导&Iota,TC-1

Abstract:Thyroid cancer-1, a nuclear protein coded byTC-1(C8orf4), regulates the cell cycle, participates transcription and translation, and is correlated with the proliferation of normal and cancer cells. TC-1 participates in the Wnt/beta-catenin signaling pathway which can promote the up-regulation of proto-oncogene. Hence it plays an important role in the malignant tuansformation and development of the tumors, such as thyroid cancer, gastric cancer and breast cancer. Therefore, as a potential tumor-associated protein, it’s likely to be used for fundamental research and gene targeting therapy.