国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (3): 218-220.

• 综述 •上一篇下一篇

表皮生长因子受体在食管癌放疗中的应用

张和平, 李建成

  1. 350014福建医科大学附属教学医院福建省肿瘤医院放疗科16病区
  • 出版日期:2012-03-08发布日期:2012-02-24
  • 通讯作者:李建成，Email: jianchengLi6@126.com E-mail:jianchengLi6@126.com
  • 基金资助:

    福建省卫生创新课题(2007-CX-4)

Application of epidermal growth factor receptor for radiotherapy of esophageal cancer

ZHANG He-Ping, LI Jian-Cheng

  1. Department of Radiation Oncology,Affiliated Teaching Hospital of Fujian Medical University , Fujian Tumor Hospital, Fuzhou 350014, China
  • Online:2012-03-08Published:2012-02-24
  • Contact:LI Jian-cheng, E-mail: jianchengLi6@126.com E-mail:jianchengLi6@126.com

PDF

1605

被引次数

8

摘要：表皮生长因子受体（EGFR）在食管癌中高表达或突变，引起肿瘤对放疗的抗拒，导致放疗效果差。抗EGFR治疗具有肿瘤放疗增敏作用，目前针对EGFR的分子靶向研究主要有人工合成的单克隆抗体、小分子酪氨酸激酶抑制剂、RNA干扰（RNAi）下调受体表达。

关键词:color: black,font-family: 宋体,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-bidi-font-family: 'Times New Roman',mso-font-kerning: 1.0pt,mso-hansi-font-family: 'Times New Roman',mso-ascii-font-family: 'Times New Roman'">食管肿瘤,受体,表皮生长因子,color: black,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">RNAcolor: black,font-family: 宋体,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-bidi-font-family: 'Times New Roman',mso-font-kerning: 1.0pt,mso-hansi-font-family: 'Times New Roman',mso-ascii-font-family: 'Times New Roman'">干扰

Abstract:Epidermal growth factor receptor (EGFR) express highly or mutant in esophageal cancer, which causing tumor resistance to radiotherapy and leading topoor radiotherapeutic effects. Treatment with anti-EGFR can get radiosensitization. There are three main types of molecular targeted research for EGFR: synthetic monoclonal antibody, small molecule tyrosine kinase inhibitors, and other strategies modulating EGFR biosynthesis based on RNA interference.

Key words:

line-height: 150%">color: black,line-height: 150%">Esophageal neoplasms,line-height: 150%,mso-bidi-font-size: 7.5pt">Receptor, epidermal growth factor,color: black,line-height: 150%">RNA interference