国际肿瘤学杂志››2012,Vol. 39››Issue (6): 403-405.

• 综述 •下一篇

肿瘤干细胞在肿瘤血管生成中的作用

张晓月,张维东

  1. 济南, betway.com 基础医学研究所实验病理研究室
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:张维东,E-mail:zhangweidongkui@163.com E-mail:zhangweidongkui@163.com
  • 基金资助:

    国家自然科学基金资助项目(81073102)

Roles of cancer stem cells in tumor angiogenesis

ZHANG Xiao-yue, ZHANG Wei-dong.

  1. Experimental Pathology Laboratory, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:ZHANG Wei-dong, E-mail: zhangweidongkui@163.com E-mail:zhangweidongkui@163.com

摘要:肿瘤干细胞(CSC)在肿瘤血管生成中有重要作用,血管生成因子、乏氧等介导了这一过程。CSC能分化成血管内皮细胞,并且参与血管生成拟态的形成,这可能是肿瘤启动和进展的关键因素之一。深入研究CSC在肿瘤血管生成中的作用对肿瘤的靶向治疗有重大意义。

关键词:肿瘤干细胞,新生血管化,病理性

Abstract:Cancer stem cells (CSC) play a crucial role in the tumor angiogenesis. Angiogenic factors and hypoxia mediate the process. CSC can differentiate into vascular endothelial cells and participate in the formation of vasculogenic mimicry, which may be one of the key factors in the initiation and progression of tumors. Indepth studies of the roles of CSC in tumor angiogenesis might help provide the basis for developing more effective therapeutic drug targets.

Key words:Neoplastic stem cells,Neovascularization, pathologic