EGFR突变的非小细胞肺癌脑转移的治疗策略

摘要/Abstract

摘要：约10%的非小细胞肺癌（NSCLC）患者初诊时出现脑转移，而脑转移为肺癌死亡的主要原因之一。目前全脑放疗（WBRT）仍为脑转移的标准治疗方案，但其疗效已达平台期。酪氨酸激酶抑制剂(TKI)在NSCLC脑转移治疗中取得了可观的疗效。TKI联合WBRT可能成为表皮生长因子受体(EGFR)突变的肺癌脑转移的主要治疗手段。

关键词:癌,非小细胞肺,治疗,转移,表皮生长因子受体

Abstract:As the leading cause of death among lung cancer patients, brain metastasis occurs in approximately 10 percent of non-small cell lung cancer (NSCLC) patients at first diagnosis. Wholebrain radiation therapy (WBRT) is still the standard treatment for patients with brain metastasis, however, the efficacy of WBRT reaches a plateau. It has been proved that tyrosine kinase inhibitors (TKIs) make considerable therapeutic effect for NSCLC patients with brain metastasis. The combination therapy of TKIs with WBRT may provide new major treatment for epidermal growth factor receptor (EGFR) mutant NSCLC with brain metastasis.

Key words:Carcinoma, non-small-cell lung,Therapy,Metastasis,Epidermal growth factor receptor

张惠博,李祥攀,宋启斌. EGFR突变的非小细胞肺癌脑转移的治疗策略[J]. 国际肿瘤学杂志, 2017, 44(4): 294-296.

Zhang Huibo, Li Xiangpan, Song Qibin. Treatment strategies of EGFR-mutated non-small cell lung cancer with brain metastases[J]. Journal of International Oncology, 2017, 44(4): 294-296.

参考文献

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