国际肿瘤学杂志

国际肿瘤学杂志››2019,Vol. 46››Issue (10): 624-626.doi:10.3760/cma.j.issn.1673-422X.2019.10.012

• 综述 •上一篇下一篇

肝细胞癌中微小RNA对mTOR信号通路的调控作用

牛亚倩,常钰玲,刘芳,楚惠媛,陈彻

  1. 甘肃中医药大学临床医学院，兰州730000

  • 出版日期:2019-10-08发布日期:2019-12-22
  • 通讯作者:陈彻，Email： chen72123@163.com E-mail:chen72123@163.com
  • 基金资助:

    国家自然科学基金（81460456）

Regulation of mTOR singnaling pathway by microRNA in hepatocellular carcinoma

Niu Yaqian, Chang Yuling, Liu Fang, Chu Huiyuan, Chen Che

  1. College of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China

  • Online:2019-10-08Published:2019-12-22
  • Contact:Chen Che, Email: chen72123@163.com E-mail:chen72123@163.com
  • Supported by:

    National Natural Science Foundation of China (81460456)

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摘要：

微小RNA（miRNA)是一种非编码小分子RNA，可作为癌基因或抑癌基因，参与肿瘤的发生发展过程。多种miRNA在肝细胞癌中表达异常，可以直接或间接作用于哺乳动物雷帕霉素靶蛋白（mTOR）信号通路中的PI3K、Akt、mTOR、IGF-1R、TGF-β等信号因子，在肝细胞癌细胞的增殖及侵袭转移中起重要作用。

关键词:

癌,肝细胞,微RNAs,TOR丝氨酸-苏氨酸激酶

Abstract:

MicroRNA (miRNA) is a non-coding small molecule RNA, which is involved in the occurrence and development of tumor as an oncogene or tumor suppressor gene. The abnormal expression of many kinds of miRNAs in hepatocellular carcinoma (HCC) can directly or indirectly act on PI3K, Akt, mTOR, IGF-1R, TGF-βand other signal molecules in mTOR signal pathway, they are crucial in the appreciation, invasion and metastasis of HCC cells.

Key words:

Carcinoma, hepatocellular,MicroRNAs,TOR serine-threonine kinases