lncRNA、circRNA调控食管鳞状细胞癌放化疗敏感性的作用机制

国际肿瘤学杂志››2022,Vol. 49››Issue (3): 185-189.doi:10.3760/cma.j.cn371439-20220104-00032

lncRNA、circRNA调控食管鳞状细胞癌放化疗敏感性的作用机制

张俊鹏^1,², 于燕燕³, 李宝生²()

¹betway必威登陆网址 (betway.com )研究生院,济南 250117
²betway必威登陆网址 (betway.com ) 山东省肿瘤防治研究院(山东省肿瘤医院)放疗科,济南 250117
³betway必威登陆网址第一附属医院(山东省千佛山医院)神经内科,济南 250013

收稿日期:2022-01-04修回日期:2022-01-12出版日期:2022-03-08发布日期:2022-03-22
通讯作者:李宝生 E-mail:bsli@sdfmu.edu.cn
基金资助:
国家自然科学基金(81530060)

Mechanism of lncRNA and circRNA regulating the sensitivity of radiotherapy and chemotherapy in esophageal squamous cell carcinoma

Zhang Junpeng^1,², Yu Yanyan³, Li Baosheng²()

¹School of Graduate, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
²Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
³Department of Neurology, First Affiliated Hospital of Shandong First Medical University, Shandong Province Qianfoshan Hospital, Jinan 250013, China

Received:2022-01-04Revised:2022-01-12Online:2022-03-08Published:2022-03-22
Contact:Li Baosheng E-mail:bsli@sdfmu.edu.cn
Supported by:
National Natural Science Foundation of China(81530060)

摘要/Abstract

摘要：

长非编码RNA(lncRNA)和环状RNA(circRNA)是两类重要的非编码RNA,可通过与DNA、RNA或蛋白质相互作用调控基因表达。lncRNA、circRNA不仅能够预测食管鳞状细胞癌(ESCC)患者的放化疗预后情况,还可以通过竞争性内源RNA机制、调控PI3K/Akt/mTOR及Wnt/β-catenin信号通路、参与DNA及蛋白质修饰、调节细胞周期等多种途径影响ESCC放化疗敏感性。对lncRNA、circRNA调控ESCC放化疗敏感性的作用机制进行深入研究,将有助于指导筛选患者人群,提高ESCC患者放化疗效果。

关键词:食管肿瘤,癌,鳞状细胞,放射疗法,化学疗法,长链非编码RNA,环状RNA

Abstract:

Long non-coding RNA (lncRNA) and circular RNA (circRNA) are two important types of non-coding RNA that can regulate gene expression by directly interacting with DNA, RNA or protein. A large number of studies have shown that lncRNA and circRNA can not only predict the prognosis of patients with esophageal squamous cell carcinoma (ESCC) after radiotherapy and chemotherapy, but also affect the sensitivity of ESCC to radiotherapy and chemotherapy through competing endogenous RNA mechanisms, regulating PI3K/Akt/mTOR and Wnt/β-catenin signaling pathways, participating in DNA and protein modification, regulating the cell cycle and other pathways. In-depth research on the mechanism of lncRNA and circRNA regulating the sensitivity of ESCC to radiotherapy and chemotherapy will improve the effect of radiotherapy and chemotherapy in ESCC patients.

Key words:Esophageal neoplasms,Carcinoma,squamous cell,Radiotherapy,Chemotherapy,Long non-coding RNA,Circular RNA

张俊鹏, 于燕燕, 李宝生. lncRNA、circRNA调控食管鳞状细胞癌放化疗敏感性的作用机制[J]. 国际肿瘤学杂志, 2022, 49(3): 185-189.

Zhang Junpeng, Yu Yanyan, Li Baosheng. Mechanism of lncRNA and circRNA regulating the sensitivity of radiotherapy and chemotherapy in esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2022, 49(3): 185-189.

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