肠道菌群与结直肠癌非手术治疗的相关研究进展

摘要/Abstract

摘要：

近年来，肠道菌群逐渐成为恶性肿瘤治疗相关研究的热点。肠道机会致病菌（如具核梭杆菌、脆弱拟杆菌）、肠道益生菌（如丁酸梭菌、乳酸菌）以及肠道致病菌（如沙门氏菌、志贺菌）可通过影响信号通路、调节自噬、调节免疫反应、产生代谢产物及毒素以及通过粪菌移植等途径影响结直肠癌放化疗和免疫治疗疗效及相关不良反应，同时为结直肠癌靶向治疗提供大量潜在靶点。进一步研究肠道菌群与结直肠癌非手术治疗的关系，可为结直肠癌非手术治疗相关基础与临床研究提供参考。

关键词:结直肠肿瘤,胃肠道微生物组,药物疗法,放射疗法,免疫疗法

Abstract:

In recent years， intestinal flora has gradually become the focus of research on the treatment of malignant neoplasms. Intestinal opportunistic pathogens （such asFusobacterium nucleatum，Bacteroides fragilis）， intestinal probiotics （such asClostridium butyricum，Lactic acid bacteria） and intestinal pathogenic bacteria （such asSalmonella，Shigella） can affect the efficacy and related adverse reactions of radiotherapy， chemotherapy and immunotherapy for the colorectal cancer （CRC） by influencing signaling pathways， modulating autophagy， regulating immune response， producing metabolites and toxins， and transplanting fecal bacteria. At the same time， it provides a large number of potential targets for targeted therapy of the CRC. Further research on the relationship between intestinal flora and non-surgical treatment of the CRC can provide references for basic and clinical research of non-surgical treatment of the CRC.

Key words:Colorectal neoplasms,Gastrointestinal microbiome,Drug therapy,Radiotherapy,Immunotherapy

高凡, 王萍, 杜超, 褚衍六. 肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.

Gao Fan, Wang Ping, Du Chao, Chu Yanliu. Research progress on intestinal flora and non-surgical treatment of the colorectal cancer[J]. Journal of International Oncology, 2024, 51(6): 376-381.

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