胃癌免疫治疗疗效预测及预后标志物的研究进展

国际肿瘤学杂志››2024,Vol. 51››Issue (3): 175-180.doi:10.3760/cma.j.cn371439-20231109-00028

胃癌免疫治疗疗效预测及预后标志物的研究进展

刘玉兰¹^,², 井海燕³, 孙静¹, 宋伟², 沙丹²()

¹山东中医药大学第二临床医学院，济南 250355
²betway必威登陆网址附属省立医院肿瘤微创综合治疗科，济南 250021
³betway必威登陆网址附属省立医院病理科，济南 250021

收稿日期:2023-11-09修回日期:2023-12-04出版日期:2024-03-08发布日期:2024-04-10
通讯作者:沙丹，Email： shadan@sdfmu.edu.cn
基金资助:
山东省自然科学基金(ZR2021MH140);济南市临床医学科技创新计划(202019085)

Advances in predicting efficacy and prognostic markers of immunotherapy for gastric cancer

Liu Yulan¹^,², Jing Haiyan³, Sun Jing¹, Song Wei², Sha Dan²()

¹Second Clinical Medical College of Shandong University of Traditional Chinese Medicine， Jinan 250355， China
²Department of Minimally Invasive Comprehensive Treatment to Cancer， Shandong Provincial Hospital Affiliated to Shandong First Medical University， Jinan 250021， China
³Department of Pathology， Shandong Provincial Hospital Affiliated to Shandong First Medical University， Jinan 250021， China

Received:2023-11-09Revised:2023-12-04Online:2024-03-08Published:2024-04-10
Contact:Sha Dan， Email： shadan@sdfmu.edu.cn
Supported by:
Natural Science Foundation of Shandong Province of China(ZR2021MH140);Science and Technology Innovation Development Program of Jinan City of Shandong Province(202019085)

摘要/Abstract

摘要：

由于胃癌具有较高的肿瘤内及肿瘤间异质性，导致患者在免疫治疗疗效和预后方面差异极大。程序性死亡受体配体1、人表皮生长因子受体2、肿瘤微环境特征、外周血炎性标志物及Claudin18.2等多种生物标志物均显示出对免疫治疗疗效和患者预后的预测价值，有助于临床医生筛选免疫治疗潜在获益人群，实现精准化治疗。

关键词:胃肿瘤,免疫疗法,预测,生物标记,肿瘤,预后

Abstract:

The high intra- and inter-tumor heterogeneity of gastric cancer leads to a great difference in the immunotherapy efficacy and the prognosis among patients. Several biomarkers， including programmed death-ligand 1， human epidermal growth factor receptor 2， the features of tumor microenvironment， the peripheral blood inflammatory markers and Claudin18.2 have predictive value in the immunotherapy efficacy and the prognosis of gastric cancer patients， which might help the clinicians find the potential patients who will benefit from immunotherapy， and achieve the goal of precision medicine.

Key words:Stomach neoplasms,Immunotherapy,Forecasting,Biomarkers,tumor,Prognosis

刘玉兰, 井海燕, 孙静, 宋伟, 沙丹. 胃癌免疫治疗疗效预测及预后标志物的研究进展[J]. 国际肿瘤学杂志, 2024, 51(3): 175-180.

Liu Yulan, Jing Haiyan, Sun Jing, Song Wei, Sha Dan. Advances in predicting efficacy and prognostic markers of immunotherapy for gastric cancer[J]. Journal of International Oncology, 2024, 51(3): 175-180.

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