铁死亡相关机制在骨肉瘤中的应用进展

国际肿瘤学杂志››2024,Vol. 51››Issue (5): 308-311.doi:10.3760/cma.j.cn371439-20240304-00052

铁死亡相关机制在骨肉瘤中的应用进展

王培鑫¹, 赵军², 徐世红²(), 姜朝阳², 王小强², 杨红娟¹

¹甘肃中医药大学中医临床学院，兰州 730000
²甘肃省中医院创伤中心，兰州 730050

收稿日期:2024-03-04修回日期:2024-04-03出版日期:2024-05-08发布日期:2024-06-26
通讯作者:徐世红，Email：308359102@qq.com
基金资助:
国家自然科学基金(82260945);兰州市科技计划(2023-2-51)

Progress of ferroptosis-related mechanisms in osteosarcoma

Wang Peixin¹, Zhao Jun², Xu Shihong²(), Jiang Zhaoyang², Wang Xiaoqiang², Yang Hongjuan¹

¹Clinical School of Traditional Chinese Medicine， Gansu University of Chinese Medicine， Lanzhou 730000， China
²Trauma Center， Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730050， China

Received:2024-03-04Revised:2024-04-03Online:2024-05-08Published:2024-06-26
Contact:Xu Shihong， Email：308359102@qq.com
Supported by:
National Natural Science Foundation of China(82260945);Lanzhou Science and Technology Program(2023-2-51)

摘要/Abstract

摘要：

骨肉瘤是一种常见的原发性恶性骨肿瘤，具有高度侵袭性和远端转移性，预后较差。铁是一种人体必需的营养素，具有电子交换能力，是细胞活动的重要参与者，其代谢异常与骨肉瘤的进展密切相关。有研究证明铁死亡可以调节骨肉瘤进展，在骨肉瘤的治疗中发挥重要作用。探讨铁死亡的相关分子机制在骨肉瘤中的应用及药物干预现状，可为骨肉瘤的治疗提供新的策略。

关键词:骨肉瘤,铁死亡,分子靶向治疗

Abstract:

Osteosarcoma is a common primary malignant bone tumor with highly aggressive and distal metastasis and poor prognosis. Abnormal metabolism of iron， an essential nutrient with electron-exchange capacity and an important participant in cellular activities， is closely associated with the progression of osteosarcoma. Ferroptosis has been shown to regulate osteosarcoma progression and play an important role in the treatment of osteosarcoma. Exploring the application of relevant molecular mechanisms of ferroptosis in osteosarcoma and the current status of pharmacological intervention may provide new strategies for the treatment of osteosarcoma.

Key words:Osteosarcoma,Ferroptosis,Molecular targeted therapy

王培鑫, 赵军, 徐世红, 姜朝阳, 王小强, 杨红娟. 铁死亡相关机制在骨肉瘤中的应用进展[J]. 国际肿瘤学杂志, 2024, 51(5): 308-311.

Wang Peixin, Zhao Jun, Xu Shihong, Jiang Zhaoyang, Wang Xiaoqiang, Yang Hongjuan. Progress of ferroptosis-related mechanisms in osteosarcoma[J]. Journal of International Oncology, 2024, 51(5): 308-311.

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