铁死亡在骨肉瘤中的分子机制及相关治疗的研究进展

国际肿瘤学杂志››2024,Vol. 51››Issue (4): 239-244.doi:10.3760/cma.j.cn371439-20231229-00040

铁死亡在骨肉瘤中的分子机制及相关治疗的研究进展

王子豪, 王宇, 杨鑫, 何艺, 莫兴奎, 袁涛()

云南省肿瘤医院（昆明医科大学第三附属医院）骨科，昆明 650118

收稿日期:2023-12-29修回日期:2024-03-01出版日期:2024-04-08发布日期:2024-05-10
通讯作者:袁涛，Email： yuantao2015@hotmail.com
作者简介:王子豪和王宇对本文有同等贡献
基金资助:
云南省科技厅科技计划(202201AT070012);昆明医科大学博士研究生创新基金(2023B10)

Research progress on the molecular mechanism and related treatments of ferroptosis in osteosarcoma

Wang Zihao, Wang Yu, Yang Xin, He Yi, Mo Xingkui, Yuan Tao()

Department of Orthopaedics， Yunnan Cancer Hospital （Third Affiliated Hospital of Kunming Medical University）， Kunming 650118， China

Received:2023-12-29Revised:2024-03-01Online:2024-04-08Published:2024-05-10
Contact:Yuan Tao， Email： yuantao2015@hotmail.com
About author:Wang Zihao and Wang Yu are contributed equally to the article
Supported by:
Science and Technology Plan of Yunnan Provincial Department of Science and Technology(202201AT070012);Doctoral Student Innovation Fund Project of Kunming Medical University(2023B10)

摘要/Abstract

摘要：

骨肉瘤作为常见的原发恶性骨肿瘤之一，因其较差的预后及较单一的治疗方式，使得目前临床对骨肉瘤患者的治疗已达到瓶颈期。然而，越来越多的研究发现铁死亡作为一种新型的细胞死亡方式，或可在骨肉瘤的治疗中发挥重要作用。近年来，随着对铁死亡相关机制及分子通路研究的愈加深入，其在骨肉瘤中的特异性治疗策略也相继得以验证，这有望为骨肉瘤患者的临床治疗提供新思路。

关键词:骨肉瘤,铁死亡,活性氧,肿瘤治疗方案

Abstract:

Osteosarcoma is one of the most common primary malignant bone tumors， which has reached a "bottleneck" in the current clinical treatment of patients with osteosarcoma due to its poor prognosis and lack of therapeutic modalities. Recently， more and more researches have found that ferroptosis， as a novel cell death modality， may play an important role in osteosarcoma treatment. In recent years， with more in-depth studies on the mechanisms and molecular pathways related to ferroptosis， its specific therapeutic strategies in osteosarcoma have also been validated， which is expected to provide new ideas for the clinical treatment of osteosarcoma patients.

Key words:Osteosarcoma,Ferroptosis,Reactive oxygen species,Antineoplastic protocols

王子豪, 王宇, 杨鑫, 何艺, 莫兴奎, 袁涛. 铁死亡在骨肉瘤中的分子机制及相关治疗的研究进展[J]. 国际肿瘤学杂志, 2024, 51(4): 239-244.

Wang Zihao, Wang Yu, Yang Xin, He Yi, Mo Xingkui, Yuan Tao. Research progress on the molecular mechanism and related treatments of ferroptosis in osteosarcoma[J]. Journal of International Oncology, 2024, 51(4): 239-244.

图/表1

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