国际肿瘤学杂志››2011,Vol. 38››Issue (12): 911-913.

• 综述 •上一篇下一篇

肿瘤微环境中的炎性机制与肿瘤转移

李卫东, 花宝金

  1. 中国中医科学院广安门医院肿瘤科
  • 出版日期:2011-12-08发布日期:2011-11-25
  • 通讯作者:花宝金, E-mail:huabaojin@sohu.com E-mail:huabaojin@sohu.com
  • 基金资助:

    国家自然科学基金资助项目 30973839

Inflammatory mechanism in tumor microenvironment and tumor metastasis

LI Wei-Dong, HUA Bao-Jin

  1. Department of Oncology, Guang’anmen Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing, 100053 China
  • Online:2011-12-08Published:2011-11-25
  • Contact:HUA Bao-jin, E-mail:huabaojin@sohu.com E-mail:huabaojin@sohu.com

摘要:炎性微环境是肿瘤微环境中影响肿瘤复发转移的关键因素之一。肿瘤炎性微环境可以通过调节上皮细胞向间充质细胞转变,启动肿瘤转移;可以通过降解细胞外基质从而破坏细胞外基质膜促进肿瘤细胞的侵袭;同时,炎性微环境促进肿瘤血管的新生为肿瘤的发生发展提供保障。

Abstract:Inflammatory microenvironment plays a key role in the tumor recurrence and metastasis. The inflammation of tumor microenvironment can start the tumor metastasis by regulating epithelial-mesenchymal transition;can improve the tumor invasion by degradation the extracellular matrix;in addition to, inflammation can supply appropriate microenvironment for tumor vascular angiogenesis.