国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (3): 163-166.

• 综述 •下一篇

肿瘤相关成纤维细胞与肿瘤相关性的研究进展

王红梅, 徐军发

  1. 523808广东医学院临床免疫学教研室广东医学院广东省医学分子诊断重点教研室
  • 出版日期:2012-03-08发布日期:2012-02-24
  • 通讯作者:徐军发，Email：imxujunfa@163.com E-mail:imxujunfa@163.com
  • 基金资助:

    国家自然科学基金资助项目（30972779）；广东省科技计划项目（2009B030801333）；东莞市科技计划项目（8452402301001083）

Advances of tumor-associated fibroblasts in carcinogenesis

WANG Hong-Mei, XU Jun-Fa

  1. *Department of ClinicalImmunology,Guangdong Medical College, Dongguan523808,China
  • Online:2012-03-08Published:2012-02-24
  • Contact:Corresponding author: XU Jun-fa, E-mail: imxujunfa@163.com E-mail:imxujunfa@163.com

PDF

2512

摘要：肿瘤微环境中基质细胞对于肿瘤的发生发展具有重要作用。肿瘤相关成纤维细胞是数量最丰富的基质细胞，在肿瘤微环境中通过细胞与细胞间相互接触，并在各种可溶性因子的作用下，促进上皮细胞及其他细胞恶性转化。

关键词:color: black,font-family: 宋体,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: HE,mso-bidi-font-family: 'Times New Roman',mso-hansi-font-family: 'Times New Roman',mso-ascii-font-family: 'Times New Roman'">血管生成抑制剂,color: black,font-family: 宋体,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: HE,mso-bidi-font-family: 'Times New Roman',mso-hansi-font-family: 'Times New Roman',mso-ascii-font-family: 'Times New Roman'">肿瘤相关成纤维细胞

Abstract:Stromal cell types of the neoplastic microenvironment play important roles in the occurrence and development of tumor.Tumor-associated fibroblasts(TAFs) are the most abundant cells in tumor stroma.They promote the malignant transformation of epithelial cells and other cells through cell-cell communication via various soluble factors.

Key words:color: black,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">Angiogenesis inhibitors,color: black,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: HE,mso-fareast-font-family: 宋体">Tumor-associated fibroblast