国际肿瘤学杂志››2012,Vol. 39››Issue (6): 408-409.

• 综述 •上一篇下一篇

自噬与恶性肿瘤侵袭转移的相关性

翁军权,侯劲松

  1. 广州, 中山大学附属口腔医院口腔颌面外科
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:侯劲松,E-mail: houjsgz@yahoo.com.cn E-mail:houjsgz@yahoo.com.cn
  • 基金资助:

    广东省自然科学基金资助项目(10151008901000025);广东省科技计划项目(2009B050700024、2009B060700096)

Autophagy and invasion and metastasis in malignant tumor

WENG Jun-quan, HOU Jin-song

  1. Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Sun Yatsen University, Guangzhou 510055, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:HOU Jin-song, E-mail: houjsgz@yahoo.com.cn E-mail:houjsgz@yahoo.com.cn

摘要:在恶性肿瘤侵袭转移的复杂生物学过程中,肿瘤细胞必须适应不同的生存压力。自噬作为一种受诸多基因及其表达产物精细调控的细胞内生理反应,不仅可被激活以适应代谢应激和微环境变化,还可能与肿瘤细胞的上皮间质转化(EMT)、肿瘤炎症、抵抗失巢凋亡、维持细胞休眠等侵袭转移机制密切相关。 

关键词:自噬,肿瘤转移

Abstract:In the complex set of biological processes that a particular malignancy to metastasize, tumor cells must adapt to different survival pressures. As an important cellphysiologic response that under regulation of many genes and their expressions, autophagy not only can be strongly induced to adapt to metabolic stresses and microenvironmental changes, but also involved in the process of epithelialmesenchymal transition (EMT), restricting inflammation, resisting anoikis, maintaining dormancy in the metastatic process.

Key words:Autophagy,Neoplasm metastasis