国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (8): 626-628.

• 综述 •上一篇下一篇

Dickkopf-1与骨转移癌

乔华, 尤丽娜, 范谷红

  1. 200940 上海市第一人民医院宝山分院肿瘤科（乔华、范谷红），科教科（尤丽娜）
  • 出版日期:2012-08-29发布日期:2012-08-29

Dickkopf-1 and bone metastases

QIAO Hua, YOU Li-Na, FAN Gu-Hong

  1. Department of Oncology, Baoshan Branch, Shanghai First People′s Hospital, Shanghai 200940, China
  • Online:2012-08-29Published:2012-08-29

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摘要：研究显示DKK-1(dickkopf-1)异常与乳腺癌、前列腺癌、多发性骨髓瘤及神经母细胞瘤等骨转移的发生及治疗效果密切相关，亦与非小细胞肺癌密切相关。进一步进行血清DKK-1水平与常见肿瘤骨转移关系的大样本临床研究，对评价DKK-1作为骨转移癌临床生物标志物的价值、了解骨转移肿瘤机制具有重要临床意义。

关键词:基因表达调控,肿瘤转移,肿瘤, 骨组织

Abstract:Recent studies show that the abnormalities of dickkopf-1 (DKK-1) are closely related to the bone metastasis and therapeutic effect of breast cancer, prostatic carcinoma, multiple myeloma, neuroblastoma and non-small cell lung cancer. Clinical researches of large sample on the relationships between serum DKK-1 concentration and malignant tumors bone metastases have important clinical significance for evaluating the value of DKK-1 as a clinical biological biomarker of bone metastases and understanding the tumor mechanisms of bone metastases .

Key words:Gene expression regulation,Neoplasm metastasis,Neoplasms, bone tissue