国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (1): 18-21.

• 综述 •上一篇下一篇

CD44在肿瘤进展中的作用

李丹华, 张斌, 曹旭晨

  1. 300060天津医科大学附属肿瘤医院乳腺一科乳腺癌防治教育部重点实验室天津市肿瘤防治重点实验室

  • 出版日期:2013-01-08发布日期:2013-01-15
  • 通讯作者:曹旭晨，E-mail：cxc@medmail.com.cn E-mail:cxc@medmail.com.cn
  • 基金资助:

    国家自然科学基金（81001186）天津市自然科学基金（10JCYBJC14100,11JCZDJC28000）

Effects of CD44 in cancer progression

LI Dan-Hua, ZHANG Bin, CAO Xu-Chen

  1. First Department of Breast Oncology,Affiliated Cancer Hospital of Tianjin Medical University;Key Laboratory of Breast Cancer Prevention and Treatment of Ministry of Education;Key Laboratory of Cancer Prevention and Treatment of Tianjin,Tianjin 300060,China
  • Online:2013-01-08Published:2013-01-15
  • Contact:Corresponding author: CAO Xu-chen, E-mail: cxc@medmail.com.cn E-mail:cxc@medmail.com.cn

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被引次数

1

摘要：CD44在生理过程及肿瘤中的作用一直是研究的热点，通过与不同配体结合，可激活一系列级联反应，不仅可以促进肿瘤形成和转移，还可以抑制肿瘤生长和进展。深入研究CD44及其在信号通路中的作用，可为肿瘤治疗提供新途径。

关键词:CD44,肿瘤转移,预后

Abstract:CD44 has been the subject of extensive research because of its role in cancer and many physiological processes. Through binding to different ligands, CD44 can initiate a series of cascade. CD44 not only can promote tumorigenic and tumor metastasis, but also can suppress tumor growth and progression. In-depth study of CD44 and its role in signal pathway may provide a new path for cancer treatment.

Key words:CD44,Neoplasm metastasis,Prognosis