国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (2): 123-126.

• 综述 •上一篇下一篇

培美曲塞在非小细胞肺癌治疗中的应用

李军, 徐向英

  1. 150081哈尔滨医科大学附属第三医院放射治疗科（李军，徐向英）；黑龙江省肿瘤防治研究所（徐向英）
  • 出版日期:2013-02-08发布日期:2013-01-25
  • 通讯作者:徐向英，E-mail:xuxxyy@sohu.com E-mail:xuxxyy@sohu.com

Application ofpemetrexedfor the treatment of non-small-cell lung cancer

LI Jun, XU Xiang-Ying

  1. Department of Radiation Oncology ,the Thi rd Affiliated Hospital ,Harbin Medical University,Harbin 150081,China
  • Online:2013-02-08Published:2013-01-25
  • Contact:Corresponding author: Xu Xing-ying, E-mail: xuxxyy@sohu.com E-mail:xuxxyy@sohu.com

PDF

2743

被引次数

4

摘要：培美曲塞是一种新型叶酸代谢拮抗剂，在欧美国家治疗非小细胞肺癌(NSCLC)方案中的疗效取得了肯定。研究表明，培美曲塞对放射线有一定的增敏效果。在培美曲塞联合放疗治疗NSCLC的临床试验中，其表现出与其他第3代化疗药物类似的疗效，并且具有更轻微的不良反应和更好的耐受性。

关键词:癌,非小细胞肺,放射疗法,培美曲塞

Abstract:Pemetrexed is a novel antifolate which is approved in the USA and Europe for the treatment of non-small-cell lung cancer (NSCLC). Researches reveal that pemetrexed enhances radiation-induced cell inactivation. A series of clinical trials of pemetrexed combined with radiotherapy for NSCLC also demonstrated that pemetrexed provides similar ef?cacy with lower toxicity and better tolerability than other third-generation chemotherapy drugs.

Key words:Carcinoma, non-samll-cell lung,Radiotherapy,Pemetrexed