国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (3): 219-221.

• 综述 •上一篇下一篇

胃癌淋巴转移实验技术与方法研究进展

丁健, 戴小军, 张晓春

  1. 210029南京中医药大学第一临床医学院(丁健)；扬州市中医院肿瘤科(戴小军、张晓春)

  • 出版日期:2013-03-08发布日期:2013-02-25
  • 通讯作者:戴小军 Email： E-mail:dxj2319@yahoo.com.cn
  • 基金资助:

    国家自然科学基金资助项目（81001589）

Experimental technology and methods of lymphatic metastasis in gastric cancer

DING Jian, DAI Xiao-Jun, ZHANG Xiao-Chun

  1. DING Jian＊, DAI Xiao-jun, ZHANG Xiao-chun.＊First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China

  • Online:2013-03-08Published:2013-02-25
  • Contact:DAI Xiao-jun, E-mail: dxj2319@yahoo.com.cn E-mail:dxj2319@yahoo.com.cn

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摘要：随着影像和分子生物技术的发展，对于胃癌淋巴转移产生机制和治疗手段的研究正广泛开展。淋巴管标志物的发现使淋巴内皮细胞可以被准确区分；免疫组织化学法、反转录聚合酶链反应等技术的应用从基因和分子层面上研究淋巴转移；分子成像技术及纳米微粒的应用为淋巴转移的诊断和治疗提供了新的手段。相关动物模型的建立让胃癌淋巴转移的实验研究顺利开展。

关键词:胃肿瘤,淋巴转移,生物学标记,研究技术,模型,动物

Abstract:With the development of imaging technique and molecular biological technique, researchers all over the world have made a great many of studies on the mechanism and treatment of lymphatic metastasis. The discovery of lymphatic endothelial cell-specific markers make it clear to distinguish lymphatic endotheliocyte. The application of new techniques such as immunohistochemical method and reverse transcription polymerase chain reaction (RT-PCR) canstudythe lymphatic metastasis from the genetic and molecular level. The application of molecular imaging and nanoparticles could provide new detection methods and therapies. The establishment of animal models offers a solid foundation for experimental study.

Key words:Stomach neoplasms,Lymphatic metastasis,Biological markers,Investigative techniques,Models, Animal