国际肿瘤学杂志››2014,Vol. 41››Issue (1): 27-30.doi:10.3760/cma.j.issn.1673-422X.2014.01.009

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贝伐珠单抗治疗脑胶质瘤及放射性脑坏死

潘雪峰, 邢红雨, 郑国宝

  1. 471031洛阳,解放军第150中心医院肿瘤科
  • 出版日期:2014-01-08发布日期:2014-01-22
  • 通讯作者:潘雪峰,E-mail: panxf-2004@163.com E-mail:panxf-2004@163.com

Bevacizumab for glioma and radiation encephalic necrosis

Pan Xuefeng, Xing Hongyu, Zheng Guobao

  1. Department of Oncology, 150th Central Hospital of the People′s Liberation Army, Luoyang 471031, China
  • Online:2014-01-08Published:2014-01-22
  • Contact:Pan Xuefeng E-mail:panxf-2004@163.com

摘要:贝伐珠单抗作为全球第一个抗血管生成的单克隆抗体,获得美国食品和药物管理局批准用于胶质母细胞瘤的挽救治疗,之后贝伐珠单抗治疗恶性胶质瘤成为研究的焦点,但最新研究结果并不支持其在恶性胶质瘤的一线治疗中应用。另外,该药在放射性脑坏死的治疗上也取得令人鼓舞的效果,确切疗效有待进一步证实。

关键词:神经胶质瘤,辐射损伤,脑,贝伐珠单抗

Abstract:The U.S. Food and Drug Administration approves bevacizumab for salvage therapy of glioblastoma in 2009, which is the first monoclonal antibody of antiangiogenesis in the global. Afterwards, bevacizumab for malignant glioma becomes the focus of research, but the latest studies do not support its use for the firstline treatment of malignant glioma. Furthermore, bevacizumab shows a encouraging effect for radiation encephalic necrosis and its final outcome remains to be further confirmed.

Key words:Glioma,Radiation injuries,Brain,Bevacizumab