炎症对上皮间质转化的调控机制

国际肿瘤学杂志››2014,Vol. 41››Issue (2): 90-93.doi:10.3760/cma.j.issn.1673-422X.2014.02.004

炎症对上皮间质转化的调控机制

单泽志, 严雪冰, 金志明

200233 上海交通大学附属第六人民医院普外科

收稿日期:2013-09-29修回日期:2013-12-08出版日期:2014-02-08发布日期:2014-01-26
通讯作者:金志明，E-mail: jzmgyp@aliyun.com E-mail:jzmgyp@aliyun.com

Regulatory mechanisms of inflammation in epithelial mesenchymal transition

Shan Zezhi, Yan Xuebing, Jin Zhiming

Department of General Surgery, Sixth People′s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China

Received:2013-09-29Revised:2013-12-08Online:2014-02-08Published:2014-01-26
Contact:Jin Zhiming E-mail:jzmgyp@aliyun.com

摘要/Abstract

摘要：炎症在肿瘤发生发展中发挥重要作用。上皮间质转化（EMT)是肿瘤增殖、侵袭及转移过程中的重要分子机制。越来越多的研究表明，炎症与EMT密切相关。在炎症微环境中，细胞因子和炎症微生物都参与EMT的调控。

单泽志, 严雪冰, 金志明. 炎症对上皮间质转化的调控机制[J]. 国际肿瘤学杂志, 2014, 41(2): 90-93.

Shan Zezhi, Yan Xuebing, Jin Zhiming. Regulatory mechanisms of inflammation in epithelial mesenchymal transition[J]. Journal of International Oncology, 2014, 41(2): 90-93.

［1］ Herrinton LJ, Liu L, Levin TR, et al. Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010［J］. Gastroenterology, 2012, 143(2): 382-389. ［2］ Raimondi S, Lowenfels AB, MorselliLabate AM, et al. Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection［J］. Best Pract Res Clin Gastroenterol, 2010, 24(3): 349-358. ［3］ Brenner DR, Boffetta P, Duell EJ, et al. Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium［J］. Am J Epidemiol, 2012, 176(7): 573-585. ［4］ Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer［J］. Cell, 2010, 140(6): 883-899. ［5］ Wang Y, Shang Y. Epigenetic control of epithelialtomesenchymal transition and cancer metastasis［J］. Exp Cell Res, 2013, 319(2): 160-169. ［6］ Meng F, Wu G. The rejuvenated scenario of epithelialmesenchymal transition (EMT) and cancer metastasis［J］. Cancer Metastasis Rev, 2012, 31(34): 455-467. ［7］ Vrba L, Jensen TJ, Garbe JC, et al. Role for DNA methylation in the regulation of miR200c and miR141 expression in normal and cancer cells［J］. PLoS One, 2010, 5(1): e8697. ［8］ Kaimori A, Potter JJ, Choti M, et al. Histone deacetylase inhibition suppresses the transforming growth factor beta1induced epithelialtomesenchymal transition in hepatocytes［J］. Hepatology, 2010, 52(3): 1033-1045. ［9］ Levy L, Hill CS. Alterations in components of the TGFbeta superfamily signaling pathways in human cancer［J］. Cytokine Growth Factor Rev, 2006, 17(12): 41-58. ［10］ vThiery JP, Acloque H, Huang RY, et al. Epithelialmesenchymal transitions in development and disease［J］. Cell, 2009, 139(5): 871-890. ［11］ Derynck R, Zhang YE. Smaddependent and Smadindependent pathways in TGFbeta family signalling［J］. Nature, 2003, 425(6958): 577584. ［12］ Miyazono K, Ehata S, Koinuma D. Tumorpromoting functions of transforming growth factorβ in progression of cancer［J］. Ups J Med Sci, 2012, 117(2): 143152. ［13］ Morrison CD, Parvani JG, Schiemann WP. The relevance of the TGFβ Paradox to EMTMET programs［J］. Cancer Lett, 2013, 341(1): 3040. ［14］ Wang H, Wang HS, Zhou BH, et al. Epithelialmesenchymal transition (EMT) Induced by TNFα requires AKT/GSK 3β mediated stabilization of snail in colorectal cancer［J］. PLoS One, 2013, 8(2): e56664. ［15］ Wang H, Fang R, Wang XF, et al. Stabilization of Snail through AKT/GSK3β signaling pathway is required for TNFαinduced epithelialmesenchymal transition in prostate cancer PC3 cells［J］. Eur J Pharmacol, 2013, 714(13): 48-55. ［16］ Maier HJ, SchmidtStrassburger U, Huber MA, et al. NFkappaB promotes epithelialmesenchymal transition, migration and invasion of pancreatic carcinoma cells［J］. Cancer Lett, 2010, 295(2): 214-228. ［17］ Tang FY, Pai MH, Chiang EP. Consumption of highfat diet induces tumor progression and epithelialmesenchymal transition of colorectal cancer in a mouse xenograft model［J］. J Nutr Biochem, 2012, 23(10): 1302-1313. ［18］ Zhao Y, Xu Y, Li Y, et al. NFκBmediated inflammation leading to EMT via miR200c is involved in cell transformation induced by cigarette smoke extract［J］. Toxicol Sci, 2013, 135(2): 265-276. ［19］ Chen MF, Lin PY, Wu CF, et al. IL6 expression regulates tumorigenicity and correlates with prognosis in bladder cancer［J］. PLoS One, 2013, 8(4): e61901. ［20］ Li XJ, Peng LX, Shao JY, et al. As an independent unfavorable prognostic factor, IL8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelialmesenchymal transition and activation of AKT signaling［J］. Carcinogenesis, 2012, 33(7): 1302-1309. ［21］ Fernando RI, Castillo MD, Litzinger M, et al. IL8 signaling plays a critical role in the epithelialmesenchymal transition of human carcinoma cells［J］. Cancer Res, 2011, 71(15): 5296-5306. ［22］ GironMichel J, Azzi S, Ferrini S, et al. Interleukin15 is a major regulator of the cellmicroenvironment interactions in human renal homeostasis［J］. Cytokine Growth Factor Rev, 2013, 24(1): 13-22. ［23］ Li Y, Wang L, Pappan L, et al. IL1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation［J］. Mol Cancer, 2012, 11: 87. ［24］ Yin Y, Grabowska AM, Clarke PA, et al. Helicobacter pylori potentiates epithelial: mesenchymal transition in gastric cancer: links to soluble HBEGF, gastrin and matrix metalloproteinase7［J］. Gut, 2010, 59(8): 1037-1045. ［25］ Yang SZ, Zhang LD, Zhang Y, et al. HBx protein induces EMT through cSrc activation in SMMC7721 hepatoma cell line［J］. Biochem Biophys Res Commun, 2009, 382(3): 555-560. ［26］ Battaglia S, Benzoubir N, Nobilet S, et al. Liver cancerderived hepatitis C virus core proteins shift TGFbeta responses from tumor suppression to epithelialmesenchymal transition［J］. PLoS One, 2009, 4(2): e4355.

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