国际肿瘤学杂志

国际肿瘤学杂志››2014,Vol. 41››Issue (10): 734-736.doi:１０．３７６０／ｃｍａ．ｊ．ｉｓｓｎ．１６７３４２２Ｘ．２０１４．１０．００５

• 综述 •上一篇下一篇

LASS家族和肿瘤

熊涛,王海峰,王剑松

  1. ６５０１０１昆明医科大学第二附属医院泌尿外科
  • 出版日期:2014-10-29发布日期:2014-10-11
  • 通讯作者:王剑松，Ｅｍａｉｌ：ｊｉａｎｓｏｎｇｗａｎｇ＠ｙａｈｏｏ．ｃｏｍ E-mail:ｊｉａｎｓｏｎｇｗａｎｇ＠ｙａｈｏｏ．ｃｏｍ
  • 基金资助:

    国家自然科学基金（８１２６０３７４）

LASS family and tumor

XIONG Tao, WANG Hai-Feng, WANG Jian-Song

  1. Department of Urology, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China
  • Online:2014-10-29Published:2014-10-11
  • Contact:ＷａｎｇＪｉａｎｓｏｎｇ E-mail:ｊｉａｎｓｏｎｇｗａｎｇ＠ｙａｈｏｏ．ｃｏｍ

PDF

1362

摘要：ＬＡＳＳ基因家族是一组高度保守的长寿基因。ＬＡＳＳ基因所编码蛋白质均具有神经酰胺合 成酶活性，可合成不同种类的神经酰胺。神经酰胺是肿瘤细胞生长、信号转导等方面的关键中间体，据 此推测 ＬＡＳＳ基因的表达可一定范围内抑制肿瘤的发生和发展。

关键词:神经酰胺类,基因,肿瘤抑制,肿瘤形成过程

Abstract:LASS gene family is a group of highly conserved and longevous gene LASS protein has a ceramide synthase activity, which can synthesize different types of ceramides. Ceramide is a key intermediate in tumor cells growth, signal transduction and other aspects. Thus it is inferred that the expression of LASS gene can suppress the occurrence and development of tumor within a certain range.

Key words:Ceramides,Genes, tumor suppressor,Neoplastic process