循环肿瘤细胞检测在非小细胞肺癌中的应用

国际肿瘤学杂志››2015,Vol. 42››Issue (4): 298-300.doi:10.3760/cma.j.issn.1673-422X.2015.04.016

循环肿瘤细胞检测在非小细胞肺癌中的应用

济南大学 betway.com 医学与生命科学学院;山东省肿瘤防治研究院胸外科（李浩）；betway.com 科技开发处（李胜）；山东省肿瘤防治研究院胸外科（张百江）

出版日期:2015-04-08发布日期:2015-04-22
通讯作者:张百江，Email：zhbaijiang@sina.com
基金资助:

国家重点基础研究发展计划(2011CB504302)

Application of circulating tumor cells detection in non-small cell lung cancer

School of Medicine and Life Sciences, University of JinanShandong Academy of Medical Sciences & Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan 250022, China

Online:2015-04-08Published:2015-04-22
Contact:Zhang Baijiang, Email: zhbaijiang@sina.com

摘要/Abstract

摘要：循环肿瘤细胞（CTC）是非小细胞肺癌（NSCLC）发生复发转移的重要原因。随着检测技术的不断发展，近期研究结果提示，CTC水平不仅可以用来判断肿瘤临床分期、评估患者预后及治疗反应，还可以用于早期NSCLC的风险评估。另外，作为一种非侵入性的“液体活检”，CTC检测能反映原发肿瘤的分子生物学及遗传学特征，有助于患者获得最佳的个体化治疗。

李浩；李胜；张百江. 循环肿瘤细胞检测在非小细胞肺癌中的应用[J]. 国际肿瘤学杂志, 2015, 42(4): 298-300.

LI Hao-；Li-Sheng-；Zhang-Bai-Jiang. Application of circulating tumor cells detection in non-small cell lung cancer[J]. Journal of International Oncology, 2015, 42(4): 298-300.

［1］ Siegel R, Naishadham D, Jemal A. Cancer statistics,2012［J］. CA Cancer J Clin, 2012,62(1): 1029. ［2］ Mazzone P, Mekhail T. Current and emerging medical treatments for nonsmall cell lung cancer: a primer for pulmonologists［J］. Respir Med, 2012,106(4): 473492. ［3］ Hou JM, Krebs M, Ward T, et al. Circulating tumor cells as a window on metastasis biology in lung cancer［J］. Am J Pathol, 2011, 178(3): 989996. ［4］ Duda DG, Ancukiewicz M, Isakoff SJ, et al. Seeds and soil: unraveling the role of local tumor stroma in distant metastasis［J］. J Natl Cancer Inst, 2014, 106(8): dju187. ［5］ Krebs MG, Metcalf RL, Carter L, et al. Molecular analysis of circulating tumour cellsbiology and biomarkers［J］. Nat Rev Clin Oncol, 2014, 11(3): 129144. ［6］ Burki TK. Late detection of lung cancer［J］. Lancet Oncol, 2014, 15(13): e590. ［7］ Ilie M, Hofman V, LongMira E, et al. "Sentinel" circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease［J］. PLoS One, 2014, 9(10): e111597. ［8］ Harouaka RA, Zhou MD, Yeh YT, et al. Flexible micro spring array device for highthroughput enrichment of viable circulating tumor cells［J］. Clin Chem, 2014, 60(2): 323333. ［9］ Weight RM, Viator JA. Detection of circulating tumor cells by photoacoustic flowmetry［J］. Methods Mol Biol, 2014, 1102: 655663. ［10］ Li Q, Qi H, Zhou HX, et al. Detection of micrometastases in peripheral blood of nonsmall cell lung cancer with a refined immunomagnetic nanoparticle enrichment assay［J］. Int J Nanomedicine, 2011, 6: 21752181. ［11］ Krebs MG, Sloane R, Priest L, et al. Evaluation and prognostic significance of circulating tumor cells in patients with nonsmallcell lung cancer［J］. J Clin Oncol, 2011, 29(12): 15561563. ［12］ Li J, Shi SB, Shi WL, et al. LUNX mRNApositive cells at different time points predict prognosis in patients with surgically resected nonsmall cell lung cancer［J］. Transl Res, 2014, 163(1): 2735. ［13］ Hofman V, Bonnetaud C, Ilie MI, et al. Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker［J］. Clin Cancer Res, 2011, 17(4): 827835.. ［14］ Zhu WF, Li J, Yu LC, et al. Prognostic value of EpCAM/MUC1 mRNApositive cells in nonsmall cell lung cancer patients［J］. Tumour Biol, 2014, 35(2): 12111219. ［15］ Du YJ, Li J, Zhu WF, et al. Survivin mRNAcirculating tumor cells predict treatment efficacy of chemotherapy and survival for advanced nonsmall cell lung cancer patients［J］. Tumour Biol, 2014, 35(5): 44994507. ［16］ Juan O, Vidal J, Gisbert R, et al. Prognostic significance of circulating tumor cells in advanced nonsmall cell lung cancer patients treated with docetaxel and gemcitabine［J］. Clin Transl Oncol, 2014, 16(7): 637643. ［17］ Dorsey JF, Kao GD, MacArthur KM, et al. Tracking viable circulating tumor cells (CTCs) in the peripheral blood of nonsmall cell lung cancer (NSCLC) patients undergoing definitive radiation therapy: Pilot study results［J］. Cancer, 2015, 121(1): 139149. ［18］ Punnoose EA, Atwal S, Liu W, et al. Evaluation of circulating tumor cells and circulating tumor DNA in nonsmall cell lung cancer: association with clinical endpoints in a phase II clinical trial of pertuzumab and erlotinib［J］. Clin Cancer Res, 2012, 18(8): 23912401. ［19］ Hashimoto M, Tanaka F, Yoneda K, et al. Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer［J］. Interact Cardiovasc Thorac Surg, 2014, 18(6): 775783. ［20］ Yu M, Bardia A, Aceto N, et al. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility［J］. Science, 2014, 345(6193): 216220. ［21］ Yu M, Bardia A, Wittner BS, et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition［J］. Science, 2013, 339(6119): 580584. ［22］ Comen E, Norton L, Massagué J. Clinical implications of cancer selfseeding［J］. Nat Rev Clin Oncol, 2011, 8(6): 369377. ［23］ Marchetti A, Del Grammastro M, Felicioni L, et al. Assessment of EGFR mutations in circulating tumor cell preparations from NSCLC patients by next generation sequencing: toward a realtime liquid biopsy for treatment［J］. PLoS One, 2014, 9(8): e103883. ［24］ Pailler E, Adam J, Barthelemy A, et al. Detection of circulating tumor cells harboring a unique ALK rearrangement in ALKpositive nonsmallcell lung cancer［J］. J Clin Oncol, 2013, 31(18):22732281.

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