上皮间质转化与肿瘤干细胞的关系

国际肿瘤学杂志››2016,Vol. 43››Issue (1): 36-38.doi:10.3760/cma.j.issn.1673-422X.2016.01.010

上皮间质转化与肿瘤干细胞的关系

陈少华,钱军

233004 蚌埠医学院第一附属医院肿瘤外三科

收稿日期:2015-06-19出版日期:2016-01-08发布日期:2015-12-03
通讯作者:钱军 E-mail:qianjun215036@sina.com
基金资助:

国家自然科学基金（81173386）

Relationship between epithelial mesenchymal transition and tumor stem cells

Chen Shaohua, Qian Jun

Department of Oncological Surgery, First Affiliated Hospital, Bengbu Medical College, Bengbu 233004, China

Received:2015-06-19Online:2016-01-08Published:2015-12-03
Contact:Qian Jun E-mail:qianjun215036@sina.com
Supported by:

National Natural Science Foundation of China (81173386）

摘要/Abstract

摘要：目前越来越多的研究显示上皮间质转化（EMT）参与了肿瘤干细胞的形成以及肿瘤细胞的浸润、迁移和转移，不仅增强了癌细胞的侵袭和转移能力，还可使细胞获得自我更新等干细胞特性，促进肿瘤干细胞的产生。因此，研究EMT与常见干细胞之间的关系对于寻找控制肿瘤侵袭和转移的有效途径有非常重要的意义，亦可为肿瘤的治疗提供新的靶点。

关键词:肿瘤干细胞,肿瘤转移,上皮间质转化

Abstract:At present, more and more studies show that epithelialmesenchymal transition (EMT) is closely associated with cancer stem cell formation and tumor cell invasion, migration and metastasis. EMT not only enhances the capacity of cancer cell invasion and metastasis, but also makes the cell obtain self regeneration and other stem cell characteristics and promotes the production of cancer stem cells. As a result, the investigation of the relationship between EMT and common stem cells can be served as a new approach for searching for effective ways to control tumor invasion and metastasis. It also can provide new targets for the treatment of tumor.

Key words:Neoplastic stem cells,Neoplasm metastasis,Epithelialmesenchymal transition

陈少华,钱军. 上皮间质转化与肿瘤干细胞的关系[J]. 国际肿瘤学杂志, 2016, 43(1): 36-38.

Chen Shaohua, Qian Jun. Relationship between epithelial mesenchymal transition and tumor stem cells[J]. Journal of International Oncology, 2016, 43(1): 36-38.

参考文献

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