Journal of International Oncology››2021,Vol. 48››Issue (3): 180-183.doi:10.3760/cma.j.cn371439-20200629-00036

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Advances in the treatment of platinum-resistant ovarian cancer with PARP inhibitors

Li Chenxi1, Zhao Hongwei2,*()

  1. 1Second Clinical College, Shanxi Medical University, Taiyuan 030001, China
    2Second Department of Gynecology, Shanxi Provincial Cancer Hospital, Taiyuan 030001, China
  • Received:2020-06-29Revised:2020-07-26Online:2021-03-08Published:2021-03-25
  • Contact:Zhao Hongwei E-mail:inmind20060829@126.com
  • Supported by:
    CSCO-Hengrui Cancer Research Fund(Y-HR2018-330);Key Research and Development Program of Shanxi Province of China(201903D321174)

Abstract:

Poly ADP-ribose polymerase(PARP)inhibitor is a targeted biological agent for the treatment of ovarian cancer, which is mainly suitable for platinum-sensitive ovarian cancer patients. However, data from clinical trials showed that PARP inhibitors have certain therapeutic effect on platinum-resistant or platinum-refractory ovarian cancer patients. It may become a new hope for treatment of ovarian cancer patients in the future.

Key words:Ovarian neoplasms,Poly(ADP-ribose) polymerase,Chemotherapy