Journal of International Oncology››2021,Vol. 48››Issue (9): 564-567.doi:10.3760/cma.j.cn371439-20210517-00110
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Zhu Feng, Wang Shiwen, Xian Jingrong, Liu Yue, Zhao Hu, Zhang Yanmei()
Received:
2021-05-17Revised:
2021-06-17Online:
2021-09-08Published:
2021-09-22Contact:
Zhang Yanmei E-mail:15618653286@163.comSupported by:
Zhu Feng, Wang Shiwen, Xian Jingrong, Liu Yue, Zhao Hu, Zhang Yanmei. Research on the anti-lung cancer effects of targeted Neddylation modifying pathway and its inhibitor MLN4924 and its mechanism[J]. Journal of International Oncology, 2021, 48(9): 564-567.
[1] | 明超, 何锐, 孙远, 等. lncRNA与小细胞肺癌[J]. 国际肿瘤学杂志, 2019, 46(10):620-623. DOI: 10.3760/cma.j.issn.1673-422X.2019.10.011. doi:10.3760/cma.j.issn.1673-422X.2019.10.011 |
[2] | Xu Q, Lin G, Xu H, et al. MLN4924 neddylation inhibitor promotes cell death in paclitaxel-resistant human lung adenocarcinoma cells[J]. Oncol Lett, 2018, 15(1):515-521. DOI: 10.3892/ol.2017.7314. doi:10.3892/ol.2017.7314 |
[3] | Ni S, Chen X, Yu Q, et al. Discovery of candesartan cilexetic as a novel neddylation inhibitor for suppressing tumor growth[J]. Eur J Med Chem, 2020, 185:111848. DOI: 10.1016/j.ejmech.2019.111848. doi:10.1016/j.ejmech.2019.111848 |
[4] | Zhou L, Zhang W, Sun Y, et al. Protein neddylation and its alterations in human cancers for targeted therapy[J]. Cell Signal, 2018, 44:92-102. DOI: 10.1016/j.cellsig.2018.01.009. doi:10.1016/j.cellsig.2018.01.009 |
[5] | Liang Y, Jiang Y, Jin X, et al. Neddylation inhibition activates the protective autophagy through NF-kappaB-catalase-ATF3 axis in human esophageal cancer cells[J]. Cell Commun Signal, 2020, 18(1):72. DOI: 10.1186/s12964-020-00576-z. doi:10.1186/s12964-020-00576-z |
[6] | Chen P, Hu T, Liang Y, et al. Neddylation inhibition activates the extrinsic apoptosis pathway through ATF4-CHOP-DR5 axis in human esophageal cancer cells[J]. Clin Cancer Res, 2016, 22(16):4145-4157. DOI: 10.1158/1078-0432.CCR-15-2254. doi:10.1158/1078-0432.CCR-15-2254 |
[7] | Li L, Kang J, Zhang W, et al. Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer[J]. EBioMedicine, 2019, 45:81-91. DOI: 10.1016/j.ebiom.2019.06.005. doi:10.1016/j.ebiom.2019.06.005 |
[8] | Jiang Y, Cheng W, Li L, et al. Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment[J]. Cell Biol Toxicol, 2020, 36(4):349-364. DOI: 10.1007/s10565-019-09503-6. doi:10.1007/s10565-019-09503-6 |
[9] | Zhou L, Jiang Y, Liu X, et al. Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-kappaB-CCL2 signaling in lung cancer[J]. Oncogene, 2019, 38(29):5792-5804. DOI: 10.1038/s41388-019-0840-4. doi:10.1038/s41388-019-0840-4 |
[10] | Zhou W, Xu J, Tan M, et al. UBE2M is a stress-inducible dual E2 for Neddylation and ubiquitylation that promotes targeted degradation of UBE2F[J]. Mol Cell, 2018, 70(6):1008-1024. e6. DOI: 10.1016/j.molcel.2018.06.002. doi:10.1016/j.molcel.2018.06.002 |
[11] | Zhou W, Xu J, Li H, et al. Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage[J]. Clin Cancer Res, 2017, 23(4):1104-1116. DOI: 10.1158/1078-0432.CCR-16-1585. doi:10.1158/1078-0432.CCR-16-1585 |
[12] | Li H, Tan M, Jia L, et al. Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis[J]. J Clin Invest, 2014, 124(2):835-846. DOI: 10.1172/JCI70297. doi:10.1172/JCI70297 |
[13] | Zhao G, Gong L, Su D, et al. Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin beta1[J]. J Clin Invest, 2019, 129(3):972-987. DOI: 10.1172/JCI122779. doi:10.1172/JCI122779 |
[14] | Hung MS, Chen IC, You L, et al. Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells[J]. J Cell Mol Med, 2016, 20(7):1295-1306. DOI: 10.1111/jcmm.12811. doi:10.1111/jcmm.12811 |
[15] | Zhou J, Zhang S, Xu Y, et al. Cullin 3 overexpression inhibits lung cancer metastasis and is associated with survival of lung adenocarcinoma[J]. Clin Exp Metastasis, 2020, 37(1):115-124. DOI: 10.1007/s10585-019-09988-9. doi:10.1007/s10585-019-09988-9 |
[16] | Ohta E, Itoh M, Ueda M, et al. Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity[J]. PLoS One, 2019, 14(7):e0219782. DOI: 10.1371/journal.pone.0219782. doi:10.1371/journal.pone.0219782 |
[17] | Zhang H, Wang A, Tan Y, et al. NCBP1 promotes the development of lung adenocarcinoma through up-regulation of CUL4B[J]. J Cell Mol Med, 2019, 23(10):6965-6977. DOI: 10.1111/jcmm.14581. doi:10.1111/jcmm.14581 |
[18] | Jia L, Yan F, Cao W, et al. Dysregulation of CUL4A and CUL4B ubiquitin ligases in lung cancer[J]. J Biol Chem, 2017, 292(7):2966-2978. DOI: 10.1074/jbc.M116.765230. doi:10.1074/jbc.M116.765230 |
[19] | Mao H, Sun Y. Neddylation-independent activities of MLN4924[J]. Adv Exp Med Biol, 2020, 1217:363-372. DOI: 10.1007/978-981-15-1025-0_21. doi:10.1007/978-981-15-1025-0_21 |
[20] | Lin S, Shang Z, Li S, et al. Neddylation inhibitor MLN4924 induces G2cell cycle arrest, DNA damage and sensitizes esophageal squamous cell carcinoma cells to cisplatin[J]. Oncol Lett, 2018, 15(2):2583-2589. DOI: 10.3892/ol.2017.7616. doi:10.3892/ol.2017.7616pmid:29434977 |
[21] | Cheng X, Ferrell JE Jr. Apoptosis propagates through the cytoplasm as trigger waves[J]. Science, 2018, 361(6402):607-612. DOI: 10.1126/science.aah4065. doi:10.1126/science.aah4065 |
[22] | Wang Y, Luo Z, Pan Y, et al. Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells[J]. Cancer Biol Ther, 2015, 16(3):420-429. DOI: 10.1080/15384047.2014.1003003. doi:10.1080/15384047.2014.1003003 |
[23] | Hernandez-Segura A, Nehme J, Demaria M. Hallmarks of cellular senescence[J]. Trends Cell Biol, 2018, 28(6):436-453. DOI: 10.1016/j.tcb.2018.02.001. doi:S0962-8924(18)30020-5pmid:29477613 |
[24] | Li L, Wang M, Yu G, et al. Overactivated neddylation pathway as a therapeutic target in lung cancer[J]. J Natl Cancer Inst, 2014, 106(6):dju083. DOI: 10.1093/jnci/dju083. doi:10.1093/jnci/dju083 |
[25] | Wood EA, Lu Z, Jia S, et al. Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence[J]. Vet Comp Oncol, 2020, 18(3):269-280. DOI: 10.1111/vco.12546. doi:10.1111/vco.12546 |
[26] | Zhou L, Jiang Y, Luo Q, et al. Neddylation: a novel modulator of the tumor microenvironment[J]. Mol Cancer, 2019, 18(1):77. DOI: 10.1186/s12943-019-0979-1. doi:10.1186/s12943-019-0979-1 |
[27] | Jiang Y, Liang Y, Li L, et al. Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis[J]. Cell Biol Toxicol, 2019, 35(3):233-245. DOI: 10.1007/s10565-019-09472-w. doi:10.1007/s10565-019-09472-w |
[28] | Lan H, Tang Z, Jin H, et al. Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells[J]. Sci Rep, 2016, 6:24218. DOI: 10.1038/srep24218. doi:10.1038/srep24218 |
[29] | Wei C, Yang C, Wang S, et al. Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circula-ting tumor cell-mediated colorectal cancer metastasis[J]. Mol Cancer, 2019, 18(1):64. DOI: 10.1186/s12943-019-0976-4. doi:10.1186/s12943-019-0976-4 |
[30] | Kabir S, Cidado J, Andersen C, et al. The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells[J]. Elife, 2019, 8:e44288. DOI: 10.7554/eLife.44288. doi:10.7554/eLife.44288 |
[31] | Li H, Zhou W, Li L, et al. Inhibition of neddylation modification sensitizes pancreatic cancer cells to gemcitabine[J]. Neoplasia, 2017, 19(6):509-518. DOI: 10.1016/j.neo.2017.04.003. doi:10.1016/j.neo.2017.04.003 |
[32] | Wang Y, Zhou Y, Zheng Z, et al. Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption[J]. Cell Death Dis, 2018, 9(11):1134. DOI: 10.1038/s41419-018-1174-9. doi:10.1038/s41419-018-1174-9 |
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