Dosimetric study of intensity-modulated radiotherapy and volumetric intensity modulated arc therapy based on the inner edge tangent field for radiotherapy after breast-conserving surgery of left-sided breast cancer

Abstract

Abstract:

ObjectiveTo explore the dosimetry difference between intensity-modulated radiotherapy （IMRT） and volumetric intensity modulated arc therapy （VMAT） based on the inner edge tangent field （IETF） after left-sided breast conserving surgery.MethodsThe localization CT and target organ at risk （OAR） data of 35 patients with left-sided breast cancer treated with IMRT after breast conserving surgery at Department of Radiotherapy in Yunnan Cancer Hospital from June 2022 to June 2023 were selected. The IETF-IMRT and the IETF-VMAT plans were designed for the same patient based on IETF， the dosimetry differences of target areas and OAR， as well as the planned execution time were compared between the two groups.ResultsDosimetry of target areas： for IETF-IMRT and IETF-VMAT， the D_98%of the planning target volume were （47.92±0.51） and （48.21±0.33） Gy， respectively， while the D_50%were （52.04±0.22） and （51.91±0.26） Gy， respectively， and the D_2%were （53.93±0.36） and （53.62±0.41） Gy， respectively， the conformity index were 0.84±0.03 and 0.87±0.02， respectively， while the homogeneity index were 0.12±0.01 and 0.10±0.01， respectively， with statistically significant differences （t=-3.87，P<0.001；t=3.53，P=0.001；t=5.30，P<0.001；t=-13.60，P<0.001；t=6.24，P<0.001）. Dosimetry of OAR： for IETF-IMRT and IETF-VMAT， the left lung V₅were （31.91±6.28）% and （33.99±6.31）%， respectively， and the V₂₀were （11.71±2.06）% and （9.73±2.12）%， respectively， with statistically significant differences （t=-4.18，P<0.001；t=12.40，P<0.001）. The right lung V₅were （0.11±0.08）% and （7.13±3.12）%， respectively， and the D_meanwere （1.05±0.12） and （2.71±0.27） Gy， respectively， with statistically significant differences （t=-33.62，P<0.001；t=-13.30，P<0.001）. The spinal cord D_2%were （1.08±0.11） and （4.83±1.40） Gy， respectively， with a statistically significant difference （t=-15.99，P<0.001）. The left lung D_meanwere （7.45±1.08） and （7.37±1.03） Gy， the heart D_meanwere （4.21±0.96） and （4.41±0.48） Gy， and the right-sided breast D_meanwere （3.74±1.52） and （3.48±1.11） Gy， respectively， with no statistically significant difference （t=1.16，P=0.253；t=-1.76，P=0.088；t=1.41，P=0.169）. Planned execution time： the execution time of IETF-IMRT and IETF-VMAT was （10.73±1.21） and （2.18±0.17） min， respectively， with a statistically significant difference （t=44.71，P<0.001）.ConclusionBoth IETF-IMRT and IETF-VMAT can meet clinical requirements， however the two techniques have their own characteristics. IETF-VMAT has better conformity and homogeneity of target region. The planned OAR dosimetry in both plans are significantly lower than the dose limit of postoperative radiotherapy for breast cancer， among which the left lung V₅， the right lung V₅， D_meanand spinal cord D_2%of IETF-IMRT are slightly lower， the left lung V₂₀of IETF-VMAT is slightly lower. IETF-VMAT significantly reduces the planned execution time compared with IETF-IMRT， thus can greatly reduce the dose deviation caused by patient position change， and significantly improve patients experience and comfort of radiotherapy. Taken together， IETF-VMAT has advantages over IETF-IMRT in radiotherapy after breast conserving surgery of left-sided breast cancer.

Key words:Breast neoplasms,Inner edge tangent field,Breast conserving surgery for breast cancer,Intensity-modulated radiotherapy,Volumetric intensity modulated arc therapy,Dosimetry

Zhao Biao, Pu Qin, Yuan Meifang, Ma Lishuang, Li Han, Yang Yi, Sun Chaoxi. Dosimetric study of intensity-modulated radiotherapy and volumetric intensity modulated arc therapy based on the inner edge tangent field for radiotherapy after breast-conserving surgery of left-sided breast cancer[J]. Journal of International Oncology, 2024, 51(7): 441-447.

Figures/Tables4

参数	IETF-IMRT	IETF-VMAT	t值	P值
D_98%（Gy）	47.92±0.51	48.21±0.33	-3.87	<0.001
D_50%（Gy）	52.04±0.22	51.91±0.26	3.53	0.001
D_2%（Gy）	53.93±0.36	53.62±0.41	5.30	<0.001
CI	0.84±0.03	0.87±0.02	-13.60	<0.001
HI	0.12±0.01	0.10±0.01	6.24	<0.001

参数	IETF-IMRT	IETF-VMAT	t值	P值
左肺
V₅（%）	31.91±6.28	33.99±6.31	-4.18	<0.001
V₂₀（%）	11.71±2.06	9.73±2.12	12.40	<0.001
D_mean（Gy）	7.45±1.08	7.37±1.03	1.16	0.253
心脏
D_mean（Gy）	4.21±0.96	4.41±0.48	-1.76	0.088
右肺
V₅（%）	0.11±0.08	7.13±3.12	-33.62	<0.001
D_mean（Gy）	1.05±0.12	2.71±0.27	-13.30	<0.001
右侧乳腺
D_mean（Gy）	3.74±1.52	3.48±1.11	1.41	0.169
脊髓
D_2%（Gy）	1.08±0.11	4.83±1.40	-15.99	<0.001

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