Journal of International Oncology››2024,Vol. 51››Issue (10): 650-654.doi:10.3760/cma.j.cn371439-20240429-00109

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Role of tumor cell-derived exosomes in the pre-metastatic niche formation in colorectal cancer

Chen Jie, Xu Hong(), Chen Yutian

  1. Department of Oncology, First Affiliated Hospital of Soochow University, Suzhou 215000, China
  • Received:2024-04-29Revised:2024-05-16Online:2024-10-08Published:2024-12-04
  • Contact:Xu Hong E-mail:13301549066@163.com

Abstract:

Distant metastasis is the main cause of death in patients with advanced colorectal cancer, and tumor cell-derived exosomes, as mediators of information transfer, are widely involved in all aspects of pre-metastatic niche formation in colorectal cancer. In-depth study of the mechanism of exosomes in the formation of pre-metastatic niche can provide new ideas for targeted therapy and prediction of tumor progression in colorectal cancer.

Key words:Exosomes,Tumor microenvironment,Colorectal neoplasms,Neoplasm metastasis,Pre-metastatic niche