Current situation and progress of hepatocellular carcinoma radiotherapy

Abstract

Abstract:Radiation therapy is a primary treatment for the unresectable hepatocellular carcinoma (HCC), including internal radiotherapy, threedimensional conformal radiotherapy, threedimensional intensity modulated radiotherapy (IMRT), stereotactic radiotherapy and radiotherapy combined with transcatheter arterial chemoembolization (TACE). For small lesions, residual or recurrent lesions after external irradiation, the internal radiotherapy can purposefully place radionuclides to increase the amount of radiation in target organs and reduce the amount of radiation in normal tissue. For the patients with unclear tumor boundary, thrombosis, lymph node metastasis or local recurrence, threedimensional conformal radiotherapy, IMRT and radiotherapy combined with TACE can better make the target highdose distribution shape fit with threedimensional space accurately, and improve the local control rate.

Key words:Carcinoma, hepatocellular,Therapy,Radiotherapy

LIANG Ning, SUN Feng-Kai, ZHANG Jian-Dong. Current situation and progress of hepatocellular carcinoma radiotherapy[J]. Journal of International Oncology, 2014, 41(3): 216-220.

References

［1］ HernandezGea V, Toffanin S, Friedman SL, et al. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma［J］. Gastroenterology, 2013, 144(3): 512527. ［2］ Herszényi L, Tulassay Z. Epidemiology of gastrointestinal and liver tumors［J］. Eur Rev Med Pharmacol Sci, 2010, 14(4): 249258. ［3］ Qian J, Luo Y, Gu X, et al. Inhibition of SENP6induced radiosensitization of human hepatocellular carcinoma cells by blocking radiationinduced NFκB activation［J］. Cancer Biother Radiopharm, 2013, 28(3): 196200. ［4］ Mazzaferro V, Sposito C, Bhoori S, et al. Yttrium90 radioembolization for intermediateadvanced hepatocellular carcinoma: a phase 2 study［J］. Hepatology, 2013, 57(5): 18261837. ［5］ Kumar A, Srivastava DN, Chau TT, et al. Inoperable hepatocellular carcinoma: transarterial 188Re HDDlabeled iodized oil for treatmentprospective multicenter clinical trial［J］. Radiology, 2007, 243(2): 509519. ［6］ Liu MT, Li SH, Chu TC, et al. Threedimensional conformal radiation therapy for unresectable hepatocellular carcinoma patients who had failed with or were unsuited for transcatheter arterial chemoembolization［J］. Jpn J Clin Oncol, 2004, 34(9): 532539. ［7］ Kim DY, Park W, Lim DH, et al. Threedimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma［J］. Cancer, 2005, 103(11): 24192426. ［8］ Kim TH, Kim DY, Park JW, et al. Threedimensional conformal radiotherapy of unresectable hepatocellular carcinoma patients for whom transcatheter arterial chemoembolization was ineffective or unsuitable［J］. Am J Clin Oncol, 2006, 29(6): 568575. ［9］ Wang W, Feng X, Zhang T, et al. Prospective evaluation of microscopic extension using wholemount preparation in patients with hepatocellular carcinoma: definition of clinical target volume for radiotherapy［J］. Radiat Oncol, 2010, 5: 73. ［10］ Wang MH, Ji Y, Zeng ZC, et al. Impact factors for microinvasion in patients with hepatocellular carcinoma: possible application to the definition of clinical tumor volume［J］. Int J Radiat Oncol Biol Phys, 2010, 76(2): 467476. ［11］ Hallman JL, Mori S, Sharp GC, et al. A fourdimensional computed tomography analysis of multiorgan abdominal motion［J］. Int J Radiat Oncol Biol Phys, 2012, 83(1): 435441. ［12］ Dawson LA, Brock KK, Kazanjian S, et al. The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy［J］. Int J Radiat Oncol Biol Phys, 2001, 51(5): 14101421. ［13］ Yang ZX, Wang D, Wang G, et al. Clinical study of recombinant adenovirusp53 combined with fractionated stereotactic radiotherapy for hepatocellular carcinoma［J］. J Cancer Res Clin Oncol, 2010, 136(4): 625630. ［14］ Tse RV, Hawkins M, Lockwood G, et al. Phase Ⅰ study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma［J］. J Clin Oncol, 2008, 26(4): 657664. ［15］ Kwon JH, Bae SH, Kim JY, et al. Longterm effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancer［J］. BMC Cancer, 2010, 10: 475. ［16］ Higuchi T, Kikuchi M, Okazaki M, et al. Hepatocellular carcinoma after transcatheter hepatic arterial embolization. A histopathologic study of 84 resected cases［J］. Cancer, 1994, 73(9): 22592267. ［17］ Meng MB, Cui YL, Lu Y, et al. Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: a systematic review and metaanalysis［J］. Radiother Oncol, 2009, 92(2): 184194. ［18］ Shim SJ, Seong J, Han KH, et al. Local radiotherapy as a complement to incomplete transcatheter arterial chemoembolization in locally advanced hepatocellular carcinoma［J］. Liver Int, 2005, 25(6): 11891196. ［19］ Zhou ZH, Liu LM, Chen WW, et al. Combined therapy of transcatheter arterial chemoembolisation and threedimensional conformal radiotherapy for hepatocellular carcinoma［J］. Br J Radiol, 2007, 80(951): 194201. ［20］ Ni S, Liu L, Shu Y. Sequential transcatheter arterial chemoembolization, threedimensional conformal radiotherapy, and highintensity focused ultrasound treatment for unresectable hepatocellular carcinoma patients［J］. J Biomed Res, 2012, 26(4): 260267. ［21］ Tournoux C, Paoletti X, Barbare JC, et al. Treatment outcomes for hepatocellular carcinoma using chemoembolization in combination with other therapies［J］. Cancer Treat Rev, 2007, 33(8): 762763. ［22］ Koo JE, Kim JH, Lim YS, et al. Combination of transarterial chemoembolization and threedimensional conformal radiotherapy for hepatocellular carcinoma with inferior vena cava tumor thrombus［J］. Int J Radiat Oncol Biol Phys, 2010, 78(1): 180187.

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