Journal of International Oncology››2014,Vol. 41››Issue (5): 327-331.doi:10.3760/cma.j.issn.1673-422X.2014.05.003

Previous ArticlesNext Articles

Molecular targeted therapy of tumor hypoxia

Li Shanshan, Xing Ligang, Sun Xiaorong

  1. School of Medical and Life Sciences, University of Ji′nan-Shandong Academy of Medical Sciences; Department of Radiation Oncology, Shandong Cancer Hospital, Ji′nan 250117, China
  • Received:2013-11-18Revised:2014-01-15Online:2014-05-08Published:2014-04-28
  • Contact:Xing Ligang E-mail:xinglg@medmail.com.cn

Abstract:Hypoxia is an inherent feature of the majority of solid tumors, which can increase the resistance of tumor cells to radiotherapy and chemotherapy, promote tumor angiogenesis and lead to poor prognosis. Therefore, targeting the hypoxic tumor cells has become a spot in cancer therapy. Bioreduction drugs can be activated by a specific reduction to become cytotoxic metabolites, thus killing hypoxic tumor cells, while small molecular targeting inhibitors can selectively act on the key point of hypoxia pathway. They have paved a new way for hypoxia targeted therapy.

Key words:Neoplasms,Anoxia,Molecular targeted therapy