cAMP signaling pathway and multiple myeloma

Abstract

Abstract:The clonal proliferations of multiple myeloma cells consist of several signaling pathways. It has been shown that cyclic adenosine monophosphate (cAMP) signaling pathway, an important intracellular messenger delivery system, is related to abnormal proliferation and apoptosis of malignant lymphoid cells including myeloma cells. Manipulating the cAMP signaling pathway could induce cell cycle arrest and apoptosis of various malignant lymphoid cells including myeloma cells, which involve mitochondrialdependent apoptosis and cAMPmodulated changes of intracellular mediators. Indepth researches and analysis of cAMPinduced apoptosis in myeloma cells would provide potential targets and possible therapeutic means in the treatment of multiple myeloma.

Key words:Multiple myeloma,Cyclic AMP,Apoptosis

Wang Yingying, Zhu Qi. cAMP signaling pathway and multiple myeloma[J]. Journal of International Oncology, 2014, 41(5): 368-370.

References

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