Abstract:ObjectiveTo explore the condition of MYC/BCL2 protein coexpression in 245 patients with diffuse large Bcell lymphoma (DLBCL) and to find the correlations among MYC/BCL2 protein coexpression, the germinal center Bcelllike (GCB) subtype and nonGCB subtype. MethodsParaffinembedded lymphoma samples from 245 patients with DLBCL were studied using immunohistochemistry for MYC, BCL2, CD10, BCL6, MUM1 and KI67. And the protein expressions of them were analyzed. ResultsIn the specimens of 245 patients with DLBCL, the patients with nonGCB were 163 (66.5%), and the patients with GCB were 82 (33.5%). The group of MYC/BCL2 protein coexpression comprised 35.9% (88/246) of the all patients. NonGCB subtype group had a significantly higher frequency of MYC/BCL2 protein coexpression than the GCB subtype group (41.7%∶24.4%; χ2=7.116, P=0.008). ConclusionThe data shows that MYC/BCL2 protein coexpression occurs significantly more commonly in the nonGCB subtype. We can predict prognosis and choose therapeutic regimen base on the assessment for MYC and BCL2 protein expression.

Key words:Lymphoma, large B-cell, diffuse,Proto-oncogene proteins c-myc,BCL2 protein